An integrated multi-omic analysis of iPSC-derived motor neurons from C9ORF72 ALS patients

Autor: Phatnani, Hemali, Kwan, Justin, Sareen, Dhruv, Broach, James R., Simmons, Zachary, Arcila-Londono, Ximena, Lee, Edward B., Van Deerlin, Vivianna M., Shneider, Neil A., Fraenkel, Ernest, Ostrow, Lyle W., Baas, Frank, Zaitlen, Noah, Berry, James D., Malaspina, Andrea, Fratta, Pietro, Cox, Gregory A., Thompson, Leslie M., Finkbeiner, Steve, Dardiotis, Efthimios, Miller, Timothy M., Chandran, Siddharthan, Pal, Suvankar, Hornstein, Eran, MacGowan, Daniel J., Heiman-Patterson, Terry, Hammell, Molly G., Patsopoulos, Nikolaos.A., Butovsky, Oleg, Dubnau, Joshua, Nath, Avindra, Bowser, Robert, Harms, Matt, Poss, Mary, Phillips-Cremins, Jennifer, Crary, John, Atassi, Nazem, Lange, Dale J., Adams, Darius J., Stefanis, Leonidas, Gotkine, Marc, Baloh, Robert H., Babu, Suma, Raj, Towfique, Paganoni, Sabrina, Shalem, Ophir, Smith, Colin, Zhang, Bin, Harris, Brent, Broce, Iris, Drory, Vivian, Ravits, John, McMillan, Corey, Menon, Vilas, Wu, Lani, Altschuler, Steven, Li, Jonathan, Lim, Ryan G., Kaye, Julia A., Dardov, Victoria, Coyne, Alyssa N., Wu, Jie, Milani, Pamela, Cheng, Andrew, Thompson, Terri G., Ornelas, Loren, Frank, Aaron, Adam, Miriam, Banuelos, Maria G., Casale, Malcolm, Cox, Veerle, Escalante-Chong, Renan, Daigle, J. Gavin, Gomez, Emilda, Hayes, Lindsey, Holewenski, Ronald, Lei, Susan, Lenail, Alex, Lima, Leandro, Mandefro, Berhan, Matlock, Andrea, Panther, Lindsay, Patel-Murray, Natasha Leanna, Pham, Jacqueline, Ramamoorthy, Divya, Sachs, Karen, Shelley, Brandon, Stocksdale, Jennifer, Trost, Hannah, Wilhelm, Mark, Venkatraman, Vidya, Wassie, Brook T., Wyman, Stacia, Yang, Stephanie, Van Eyk, Jennifer E., Lloyd, Thomas E., Finkbeiner, Steven, Rothstein, Jeffrey D., Svendsen, Clive N.

Publikováno v: In iScience 19 November 2021 24(11)

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Developmental alterations in Huntington's disease neural cells and pharmacological rescue in cells and mice

Autor: HD iPSC Consortium, Lim, Ryan G, Salazar, Lisa L, Wilton, Daniel K, King, Alvin R, Stocksdale, Jennifer T, Sharifabad, Delaram, Lau, L Alice, Stevens, Beth, Reidling, Jack C, Winokur, Sara T, Casale, Malcolm S, Thompson, Leslie M, Pardo, Mónica, Díaz-Barriga, A Gerardo García, Straccia, Marco, Sanders, Phil, Alberch, Jordi, Canals, Josep M, Kaye, Julia A, Dunlap, Mariah, Jo, Lisa, May, Hanna, Mount, Elliot, Anderson-Bergman, Cliff, Haston, Kelly, Finkbeiner, Steven, Allen, Nicholas D, Kemp, Paul J, Atwal, Ranjit Singh, Biagioli, Marta, Gusella, James F, MacDonald, Marcy E, Akimov, Sergey S, Arbez, Nicolas, Stewart, Jacqueline, Ross, Christopher A, Mattis, Virginia B, Tom, Colton M, Ornelas, Loren, Sahabian, Anais, Lenaeus, Lindsay, Mandefro, Berhan, Sareen, Dhruv, Svendsen, Clive N, Kedaigle, Amanda Joy, Wasylenko, Theresa Anne, Yildirim, Ferah, Ng, Christopher W., Milani, Pamela, Housman, David E, Fraenkel, Ernest

Publikováno v: Lim, RG; Salazar, LL; Wilton, DK; King, AR; Stocksdale, JT; Sharifabad, D; et al.(2017). Developmental alterations in Huntington's disease neural cells and pharmacological rescue in cells and mice. Nature Neuroscience, 20(5), 648-660. doi: 10.1038/nn.4532. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/0b73w87p
PMC
Recercat. Dipósit de la Recerca de Catalunya
instname
Dipòsit Digital de la UB
Universidad de Barcelona

Neural cultures derived from Huntington's disease (HD) patient-derived induced pluripotent stem cells were used for 'omics' analyses to identify mechanisms underlying neurodegeneration. RNA-seq analysis identified genes in glutamate and GABA signalin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb6a594baf1d75f869aa29d0096e1d45
https://doi.org/10.1038/nn.4532

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The Library of Integrated Network-Based Cellular Signatures NIH Program: System-Level Cataloging of Human Cells Response to Perturbations

Autor: Keenan, Alexandra B, Jenkins, Sherry L, Jagodnik, Kathleen M, Koplev, Simon, He, Edward, Torre, Denis, Wang, Zichen, Dohlman, Anders B, Silverstein, Moshe C, Lachmann, Alexander, Kuleshov, Maxim V, Ma'ayan, Avi, Stathias, Vasileios, Terryn, Raymond, Cooper, Daniel, Forlin, Michele, Koleti, Amar, Vidovic, Dusica, Chung, Caty, Schürer, Stephan C, Vasiliauskas, Jouzas, Pilarczyk, Marcin, Shamsaei, Behrouz, Fazel, Mehdi, Ren, Yan, Niu, Wen, Clark, Nicholas A, White, Shana, Mahi, Naim, Zhang, Lixia, Kouril, Michal, Reichard, John F, Sivaganesan, Siva, Medvedovic, Mario, Meller, Jaroslaw, Koch, Rick J, Birtwistle, Marc R, Iyengar, Ravi, Sobie, Eric A, Azeloglu, Evren U, Kaye, Julia, Osterloh, Jeannette, Haston, Kelly, Kalra, Jaslin, Finkbiener, Steve, Li, Jonathan, Milani, Pamela, Adam, Miriam, Escalante-Chong, Renan, Sachs, Karen, Lenail, Alex, Ramamoorthy, Divya, Fraenkel, Ernest, Daigle, Gavin, Hussain, Uzma, Coye, Alyssa, Rothstein, Jeffrey, Sareen, Dhruv, Ornelas, Loren, Banuelos, Maria, Mandefro, Berhan, Ho, Ritchie, Svendsen, Clive N, Lim, Ryan G, Stocksdale, Jennifer, Casale, Malcolm S, Thompson, Terri G, Wu, Jie, Thompson, Leslie M, Dardov, Victoria, Venkatraman, Vidya, Matlock, Andrea, Van Eyk, Jennifer E, Jaffe, Jacob D, Papanastasiou, Malvina, Subramanian, Aravind, Golub, Todd R, Erickson, Sean D, Fallahi-Sichani, Mohammad, Hafner, Marc, Gray, Nathanael S, Lin, Jia-Ren, Mills, Caitlin E, Muhlich, Jeremy L, Niepel, Mario, Shamu, Caroline E, Williams, Elizabeth H, Wrobel, David, Sorger, Peter K, Heiser, Laura M, Gray, Joe W, Korkola, James E, Mills, Gordon B, LaBarge, Mark, Feiler, Heidi S, Dane, Mark A, Bucher, Elmar, Nederlof, Michel, Sudar, Damir, Gross, Sean

Publikováno v: Cell systems, vol 6, iss 1

The Library of Integrated Network-Based Cellular Signatures (LINCS) is an NIH Common Fund program that catalogs how human cells globally respond to chemical, genetic, and disease perturbations. Resources generated by LINCS include experimental and co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::0d5ede2ec19252bd3d6a2811a8ea09ec
https://escholarship.org/uc/item/18t2041r