Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Milan R Savani"'
Autor:
Joseph D Buehler, Cylaina E Bird, Milan R Savani, Lauren C Gattie, William H Hicks, Michael M Levitt, Mohamad El Shami, Kimmo J Hatanpaa, Timothy E Richardson, Samuel K McBrayer, Kalil G Abdullah
Publikováno v:
Cancer Informatics, Vol 21 (2022)
The creation of patient-derived cancer organoids represents a key advance in preclinical modeling and has recently been applied to a variety of human solid tumor types. However, conventional methods used to assess in vivo tumor tissue treatment respo
Externí odkaz:
https://doaj.org/article/12674b086d134b5cb1505f9925a80c9f
Autor:
Mohamad El Shami, Milan R Savani, Lauren C Gattie, Bailey Smith, William H Hicks, Jeremy N Rich, Timothy E Richardson, Samuel K McBrayer, Kalil G Abdullah
Publikováno v:
bioRxiv
Purpose: Metabolism within the tumor microenvironment (TME) represents an increasing area of interest to understand glioma initiation and progression. Stable isotope tracing is a technique critical to the study of tumor metabolism. Cell culture model
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cec83769172783afc1a682f89e7f6885
https://europepmc.org/articles/PMC10312566/
https://europepmc.org/articles/PMC10312566/
Autor:
Shiyou Wei, Delong Yin, Shengnan Yu, Xiang Lin, Milan R. Savani, Kuang Du, Yin Ku, Di Wu, Shasha Li, Hao Liu, Meng Tian, Yaohui Chen, Michelle Bowie, Seethalakshmi Hariharan, Matthew Waitkus, Stephen T. Keir, Eric T. Sugarman, Rebecca A. Deek, Marilyne Labrie, Mustafa Khasraw, Yiling Lu, Gordon B. Mills, Meenhard Herlyn, Kongming Wu, Lunxu Liu, Zhi Wei, Keith T. Flaherty, Kalil Abdullah, Gao Zhang, David M. Ashley
Publikováno v:
Clin Cancer Res
Purpose: To investigate the antitumor activity of a mitochondrial-localized HSP90 inhibitor, Gamitrinib, in multiple glioma models, and to elucidate the antitumor mechanisms of Gamitrinib in gliomas. Experimental Design: A broad panel of primary and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b08e5a6b00175ed0fa60d8406fb66e1f
https://doi.org/10.1158/1078-0432.ccr-21-0833
https://doi.org/10.1158/1078-0432.ccr-21-0833
Autor:
David M. Ashley, Gao Zhang, Kalil Abdullah, Keith T. Flaherty, Zhi Wei, Lunxu Liu, Kongming Wu, Meenhard Herlyn, Gordon B. Mills, Yiling Lu, Mustafa Khasraw, Marilyne Labrie, Rebecca A. Deek, Eric T. Sugarman, Stephen T. Keir, Matthew Waitkus, Seethalakshmi Hariharan, Michelle Bowie, Yaohui Chen, Meng Tian, Hao Liu, Shasha Li, Di Wu, Yin Ku, Kuang Du, Milan R. Savani, Xiang Lin, Shengnan Yu, Delong Yin, Shiyou Wei
Purpose:To investigate the antitumor activity of a mitochondrial-localized HSP90 inhibitor, Gamitrinib, in multiple glioma models, and to elucidate the antitumor mechanisms of Gamitrinib in gliomas.Experimental Design:A broad panel of primary and tem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a39e0676f02af7fe1abaebded386255a
https://doi.org/10.1158/1078-0432.c.6530888.v1
https://doi.org/10.1158/1078-0432.c.6530888.v1
Autor:
Matthew D. Weitzman, Gerald B. Wertheim, Milan R. Savani, Morgann A. Reed, Katharina E. Hayer, Konstantin Budagyan, Abby M. Green
Mutational signatures in cancer genomes have implicated the APOBEC3 cytosine deaminases in oncogenesis, possibly offering a therapeutic vulnerability. Elevated APOBEC3B expression has been detected in solid tumors, but expression of APOBEC3A (A3A) in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4ef0826bbe1d1bea3d72b574ef0ab5c3
https://doi.org/10.1158/0008-5472.c.6509102.v1
https://doi.org/10.1158/0008-5472.c.6509102.v1
Autor:
David M. Ashley, Gao Zhang, Kalil Abdullah, Keith T. Flaherty, Zhi Wei, Lunxu Liu, Kongming Wu, Meenhard Herlyn, Gordon B. Mills, Yiling Lu, Mustafa Khasraw, Marilyne Labrie, Rebecca A. Deek, Eric T. Sugarman, Stephen T. Keir, Matthew Waitkus, Seethalakshmi Hariharan, Michelle Bowie, Yaohui Chen, Meng Tian, Hao Liu, Shasha Li, Di Wu, Yin Ku, Kuang Du, Milan R. Savani, Xiang Lin, Shengnan Yu, Delong Yin, Shiyou Wei
Supplementary Data from Antitumor Activity of a Mitochondrial-Targeted HSP90 Inhibitor in Gliomas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b0fc1085e2fc7cb4f5c590c31efb28d
https://doi.org/10.1158/1078-0432.22482311
https://doi.org/10.1158/1078-0432.22482311
Autor:
Matthew D. Weitzman, Gerald B. Wertheim, Milan R. Savani, Morgann A. Reed, Katharina E. Hayer, Konstantin Budagyan, Abby M. Green
Raw data and analysis of RNA-sequencing and qPCR evaluation of APOBEC3 expression in AML.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20ed6dc22f89b62e4a0caeb61ffc3c9c
https://doi.org/10.1158/0008-5472.22414877.v1
https://doi.org/10.1158/0008-5472.22414877.v1
Autor:
David M. Ashley, Gao Zhang, Kalil Abdullah, Keith T. Flaherty, Zhi Wei, Lunxu Liu, Kongming Wu, Meenhard Herlyn, Gordon B. Mills, Yiling Lu, Mustafa Khasraw, Marilyne Labrie, Rebecca A. Deek, Eric T. Sugarman, Stephen T. Keir, Matthew Waitkus, Seethalakshmi Hariharan, Michelle Bowie, Yaohui Chen, Meng Tian, Hao Liu, Shasha Li, Di Wu, Yin Ku, Kuang Du, Milan R. Savani, Xiang Lin, Shengnan Yu, Delong Yin, Shiyou Wei
Supplementary Figure from Antitumor Activity of a Mitochondrial-Targeted HSP90 Inhibitor in Gliomas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a2b681227a4f0af48b72dc2508b08fb
https://doi.org/10.1158/1078-0432.22482296
https://doi.org/10.1158/1078-0432.22482296
Autor:
Timothy E. Richardson, Gao Zhang, Joseph Buehler, William H. Hicks, Michael M Levitt, Milan R. Savani, Toral R. Patel, Cylaina E. Bird, David M. Ashley, Lauren C. Gattie, Tomas Garzon-Muvdi, Kimmo J. Hatanpaa, Denise M.O. Ramirez, Alex C. Sternisha, Wenhao Li, Kalil G. Abdullah, Samuel L. Barnett, Samuel K. McBrayer, Yi Xiao
Publikováno v:
Neuro-Oncology. 24:612-623
Background Historically, creating patient-derived models of lower-grade glioma (LGG) has been challenging, contributing to few experimental platforms that support laboratory-based investigations of this disease. Although organoid modeling approaches
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7837cbb159ea166f5ea43bc85b50f07e
https://doi.org/10.1093/neuonc/noab273
https://doi.org/10.1093/neuonc/noab273
Autor:
Januka Khanal, Daniel P. Cahill, Joseph Buehler, Diana D. Shi, Yu-Fen Lin, Misty S. Martin-Sandoval, Michael M Levitt, Keith L. Ligon, Harley I. Kornblum, Adam C. Wang, Sungwoo Lee, Dennis M. Bonal, John M. Asara, Mark A. Lehrman, Isaac S. Harris, Andreas Janzer, Cylaina E. Bird, Michael Jeffers, Ralph J. DeBerardinis, William G. Kaelin, Tammie Dang, Nathalie Y. R. Agar, Sylwia A. Stopka, Lauren C. Gattie, Stefan Gradl, Lauren G. Zacharias, Michael S. Regan, Quang-Dé Nguyen, Tak W. Mak, Sabina Signoretti, Kalil G. Abdullah, Peter Ly, Andreas Sutter, Timothy E. Richardson, Samuel K. McBrayer, Thomas P. Mathews, Milan R. Savani, Jennifer E. Endress, Min Xu, Wenhua Gao, Bofu Huang, Rebecca B. Jennings, Ryan E. Looper
SUMMARYMutations affecting isocitrate dehydrogenase (IDH) enzymes are prevalent in glioma, leukemia, and other cancers. Although mutant IDH inhibitors are effective against leukemia, they appear less active in aggressive glioma, underscoring the need
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ef99b65b0828b3d636a1f8cfa0b31ac5
https://doi.org/10.1101/2021.11.30.470443
https://doi.org/10.1101/2021.11.30.470443