Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Milan Kuchar"'
Autor:
Petr Kosztyu, Milan Kuchar, Jiri Cerny, Lucia Barkocziova, Michal Maly, Hana Petrokova, Lydie Czernekova, Veronika Liskova, Leona Raskova Kafkova, Pavlina Knotigova, Josef Masek, Jaroslav Turanek, Petr Maly, Milan Raska
Publikováno v:
EBioMedicine, Vol 47, Iss , Pp 247-256 (2019)
Background: The development of an effective vaccine preventing HIV-1 infection is hindered by the enormous antigenic variability and unique biochemical and immunological properties of HIV-1 Env glycoprotein, the most promising target for HIV-1 neutra
Externí odkaz:
https://doaj.org/article/766038e16e974b7fb6d548862f5e1bfd
Autor:
Milan Kuchař, Kristýna Sloupenská, Leona Rašková Kafková, Yaroslava Groza, Jozef Škarda, Petr Kosztyu, Marie Hlavničková, Joanna M. Mierzwicka, Radim Osička, Hana Petroková, Stephen I. Walimbwa, Shiv Bharadwaj, Jiří Černý, Milan Raška, Petr Malý
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-20 (2024)
Abstract Background Human interleukin-22 (IL-22) is known as a “dual function” cytokine that acts as a master regulator to maintain homeostasis, structural integrity of the intestinal epithelial barrier, and shielding against bacterial pathogens.
Externí odkaz:
https://doaj.org/article/7572fe8ba3d04303a546ae87cac08392
Autor:
Yaroslava Groza, Lukáš Lacina, Milan Kuchař, Leona Rašková Kafková, Kateřina Zachová, Olga Janoušková, Radim Osička, Jiří Černý, Hana Petroková, Joanna Maria Mierzwicka, Natalya Panova, Petr Kosztyu, Kristýna Sloupenská, Jan Malý, Jozef Škarda, Milan Raška, Karel Smetana, Petr Malý
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-26 (2024)
Abstract Background Interleukin-6 (IL-6) is a multifunctional cytokine that controls the immune response, and its role has been described in the development of autoimmune diseases. Signaling via its cognate IL-6 receptor (IL-6R) complex is critical i
Externí odkaz:
https://doaj.org/article/60f3248bbe5d4cae877f072b508159d0
Autor:
Joanna Maria Mierzwicka, Hana Petroková, Leona Rašková Kafková, Petr Kosztyu, Jiří Černý, Milan Kuchař, Miloš Petřík, Kateřina Bendová, Kristýna Krasulová, Yaroslava Groza, Lucie Vaňková, Shiv Bharadwaj, Natalya Panova, Michal Křupka, Jozef Škarda, Milan Raška, Petr Malý
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-19 (2024)
Abstract Background Programmed cell death 1 (PD-1) belongs to immune checkpoint proteins ensuring negative regulation of the immune response. In non-small cell lung cancer (NSCLC), the sensitivity to treatment with anti-PD-1 therapeutics, and its eff
Externí odkaz:
https://doaj.org/article/12d21b9a3d6c426188cee02bbd727d27
Autor:
Marek Maly, Jiri Cerny, Petr Kosztyu, Petr Maly, Lucia Barkocziova, Jaroslav Turánek, Pavlína Turánek Knotigová, Veronika Liskova, Milan Raska, Lýdie Czerneková, Josef Mašek, Milan Kuchar, Hana Petroková, L. Raskova Kafkova
Publikováno v:
EBioMedicine. 47:247-256
Background: The development of effective vaccine preventing HIV-1 infection is hindered by enormous antigenic variability and unique biochemical and immunological properties of HIV-1 Env glycoprotein, the most promising target for HIV-1 neutralizing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f075bb9958cbb1ee767c8f7cfbd899c2
https://doi.org/10.1016/j.ebiom.2019.07.015
https://doi.org/10.1016/j.ebiom.2019.07.015
Autor:
Milan Raska, Stuart Macaulay, Andrea Vítečková Wünschová, František Hubatka, Pavel Kulich, Eva Vohlídalová, Petr Malý, Robert Mikulik, Pavlína Turánek Knotigová, Jan Kotouček, Josef Mašek, Jan E. Dyr, Hana Štikarová, Eliška Bartheldyová, Hana Petroková, Jaroslav Turánek, Milan Kuchar
Publikováno v:
Stroke. 51
Introduction: Direct clot targeting represents attractive concept for clot imaging as well as targeted delivery of drugs, e.g. thrombolytics. Small protein binders attached to nanoliposomes may target thrombi and deliver drugs although selective affi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ec99bfff2966a7ca0bd02c063a604371
https://doi.org/10.1161/str.51.suppl_1.wp313
https://doi.org/10.1161/str.51.suppl_1.wp313
Autor:
Peter Sebo, Marek Maly, Dietmar Appelhans, Ondrej Stanek, Jan Frolik, Marcel Štofik, Dominika Wrobel, Jan Čermák, Lucie Červenková Št’astná, Jan Maly, Milan Kuchar, Petr Maly, Franka Ennen, Tereza Knapova, Alena Semerádtová
Publikováno v:
Macromolecular Bioscience. 16:553-566
For the design of a biohybrid structure as a ligand-tailored drug delivery system (DDS), it is highly sophisticated to fabricate a DDS based on smoothly controllable conjugation steps. This article reports on the synthesis and the characterization of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18a71105257311d8a00f8871cd30e552
https://doi.org/10.1002/mabi.201500332
https://doi.org/10.1002/mabi.201500332
Autor:
Tatiana Kubičárová, Petra Procházková Schrumpfová, Milan Kuchar, Gabriela Mikova, Jiri Fajkus, Lenka Skrisovska
Publikováno v:
Genome. 47:316-324
Telomere-binding proteins participate in forming a functional nucleoprotein structure at chromosome ends. Using a genomic approach, two Arabidopsis thaliana genes coding for candidate Myb-like telomere binding proteins were cloned and expressed in E.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d3e6b8f4ca4b698d8e742061ad9fd6b
https://doi.org/10.1139/g03-136
https://doi.org/10.1139/g03-136
Autor:
Milan Kuchar, Jaroslav Matoušek, Conrad P. Lichtenstein, Jörg Schubert, Petr Děakedič, Lukas Vrba, Jirí Ptáček
Publikováno v:
Archives Of Phytopathology And Plant Protection. 33:381-394
A system combining antisense RNA and RNAseIII‐binding activity was designed. Two antisense RNA vehicles, 7SL RNA and tRNA genes containing the coat protein leader domain (2245–2316) and “zinc finger”; domain (3325–3411) of PVS, respectively
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4ed8cca654ed35374c90e2149d2f9eac
https://doi.org/10.1080/03235400109383360
https://doi.org/10.1080/03235400109383360
Autor:
Milan Kuchař, Petr Kosztyu, Veronika Daniel Lišková, Jiří Černý, Hana Petroková, Eliška Vróblová, Michal Malý, Lucie Vaňková, Michal Křupka, Leona Rašková Kafková, Pavlína Turánek Knotigová, Jarmila Dušková, Jan Dohnálek, Josef Mašek, Jaroslav Turánek, Milan Raška, Petr Malý
Publikováno v:
Virulence, Vol 12, Iss 1, Pp 1271-1287 (2021)
One of the proposed strategies for the development of a more efficient HIV-1 vaccine is based on the identification of proteins binding to a paratope of chosen broadly neutralizing antibody (bNAb) that will mimic cognate HIV-1 Env (glyco)protein epit
Externí odkaz:
https://doaj.org/article/e2fc21396ad441c3bd13ab1fc43190d2