Zobrazeno 1 - 10
of 151
pro vyhledávání: '"Milan Kolář"'
Delivery of N-heterocyclic drugs, acids, phenols, and thiols via Tailor−made Self−immolative linkers
Autor:
Vahid Barati, Anna Hruzíková, Eliška Procházková, Martin Zavřel, Jaroslav Kozák, Jana Trylčová, Dominik Rejman, Jan Weber, Kateřina Bogdanová, Milan Kolář, Ondřej Baszczyňski
Publikováno v:
European Journal of Medicinal Chemistry Reports, Vol 12, Iss , Pp 100216- (2024)
Heterocyclic drugs display diverse pharmacological activities and metabolic stability. However, their poor solubility and pharmacokinetic properties often compromise bioavailability and clinical outcomes. Nevertheless, the prodrug approach provides a
Externí odkaz:
https://doaj.org/article/02da55a35360455dbc11c50a0c3d790f
Autor:
Lenka Doubravská, Miroslava Htoutou Sedláková, Kateřina Fišerová, Olga Klementová, Radovan Turek, Kateřina Langová, Milan Kolář
Publikováno v:
Antibiotics, Vol 13, Iss 2, p 192 (2024)
The impact of bacterial pneumonia on patients with COVID-19 infection remains unclear. This prospective observational monocentric cohort study aims to determine the incidence of bacterial community- and hospital-acquired pneumonia (CAP and HAP) and i
Externí odkaz:
https://doaj.org/article/c1d2b54f432a4b04bc75b159c58562c3
Autor:
Lucie Hochvaldová, David Panáček, Lucie Válková, Robert Prucek, Věra Kohlová, Renata Večeřová, Milan Kolář, Libor Kvítek, Aleš Panáček
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-9 (2022)
Abstract The number of antibiotic-resistant bacterial strains is increasing due to the excessive and inappropriate use of antibiotics, which are therefore becoming ineffective. Here, we report an effective way of enhancing and restoring the antibacte
Externí odkaz:
https://doaj.org/article/8933bc11e28745219d0e33bfb968567d
Publikováno v:
Pharmaceutics, Vol 15, Iss 10, p 2395 (2023)
Lipophosphonoxins (LPPOs) represent a new group of membrane-targeting antibiotics. Three generations of LPPOs have been described: First-generation LPPOs, second-generation LPPOs, and LEGO-LPPOs. All three generations have a similar mode of bacterici
Externí odkaz:
https://doaj.org/article/21b569a949be47a5a5943445585ce010
Autor:
Klára Látrová, Noemi Havlová, Renata Večeřová, Dominik Pinkas, Kateřina Bogdanová, Milan Kolář, Radovan Fišer, Ivo Konopásek, Duy Dinh Do Pham, Dominik Rejman, Gabriela Mikušová
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Abstract Lipophosphonoxins (LPPOs) are small modular synthetic antibacterial compounds that target the cytoplasmic membrane. First-generation LPPOs (LPPO I) exhibit an antimicrobial activity against Gram-positive bacteria; however they do not exhibit
Externí odkaz:
https://doaj.org/article/2c8af9111366446e9e22f3b263b30b4d
Autor:
Robert Prucek, Aleš Panáček, Žaneta Gajdová, Renata Večeřová, Libor Kvítek, Jiří Gallo, Milan Kolář
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Targeted and effective therapy of diseases demands utilization of rapid methods of identification of the given markers. Surface enhanced Raman spectroscopy (SERS) in conjunction with streptavidin–biotin complex is a promising alternative t
Externí odkaz:
https://doaj.org/article/a60099648a2b47b8bd6c2823925611cc
Autor:
Zuzana Malá, Ludmila Žárská, Lukáš Malina, Kateřina Langová, Renata Večeřová, Milan Kolář, Petr Henke, Jiří Mosinger, Hana Kolářová
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract Photodynamic inactivation (PDI) is a promising approach for the efficient killing of pathogenic microbes. In this study, the photodynamic effect of sulfonated polystyrene nanoparticles with encapsulated hydrophobic 5,10,15,20-tetraphenylporp
Externí odkaz:
https://doaj.org/article/d450835664094fce98a6e76861dceeb9
Autor:
Eva Zborníková, Jiří Gallo, Renata Večeřová, Kateřina Bogdanová, Milan Kolář, Dragana Vítovská, Duy Dinh Do Pham, Ondřej Pačes, Viktor Mojr, Hana Šanderová, Jitka Ulrichová, Adéla Galandáková, Drahomír Čadek, Zdeněk Hrdlička, Libor Krásný, Dominik Rejman
Publikováno v:
ACS Omega, Vol 5, Iss 7, Pp 3165-3171 (2020)
Externí odkaz:
https://doaj.org/article/e64a31f187e142679597e8e7a2d6590d
Autor:
Martin Čerňan, Tomáš Szotkowski, Jiří Minařík, Milan Kolář, Pavel Sauer, Vojtěch Látal, Jana Zapletalová, Tomáš Papajík
Publikováno v:
Life, Vol 12, Iss 8, p 1184 (2022)
Vaccination is an important tool in the fight against the COVID-19 pandemic in patients with haematologic malignancies. The paper provides an analysis of the course of breakthrough SARS-CoV-2 infection in a group of vaccinated patients with haematolo
Externí odkaz:
https://doaj.org/article/71374c0f800f4aacabaf1150c0777feb
Autor:
David Panáček, Lucie Hochvaldová, Aristides Bakandritsos, Tomáš Malina, Michal Langer, Jan Belza, Jana Martincová, Renata Večeřová, Petr Lazar, Kateřina Poláková, Jan Kolařík, Lucie Válková, Milan Kolář, Michal Otyepka, Aleš Panáček, Radek Zbořil
Publikováno v:
Advanced Science, Vol 8, Iss 12, Pp n/a-n/a (2021)
Abstract The ability of bacteria to develop resistance to antibiotics is threatening one of the pillars of modern medicine. It was recently understood that bacteria can develop resistance even to silver nanoparticles by starting to produce flagellin,
Externí odkaz:
https://doaj.org/article/bac9ae460b8c4dc28d1491f922fda0e3