Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Milan Grofik"'
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 15, p 8425 (2024)
Neurodegenerative diseases represent an increasing economic, social, and, above all, medical burden worldwide. The second most prevalent disease in this category is Parkinson’s disease, surpassed only by Alzheimer’s. It is a treatable but still i
Externí odkaz:
https://doaj.org/article/66c003a3d1204bc895106dc0704cc637
Autor:
Petra Parvanovova, Andrea Evinova, Milan Grofik, Petra Hnilicova, Zuzana Tatarkova, Monika Turcanova-Koprusakova
Publikováno v:
Biomedicines, Vol 12, Iss 6, p 1294 (2024)
Amyotrophic lateral sclerosis is a severe neurodegenerative disease whose exact cause is still unclear. Currently, research attention is turning to the mitochondrion as a critical organelle of energy metabolism. Current knowledge is sufficient to con
Externí odkaz:
https://doaj.org/article/e7854945f60e4d3d985e1b308cc828ce
Autor:
Monika Turčanová Koprušáková, Milan Grofik, Ema Kantorová, Petra Jungová, Ján Chandoga, Martin Kolisek, Peter Valkovič, Matej Škorvánek, Rafal Ploski, Egon Kurča, Štefan Sivák
Publikováno v:
BMC Neurology, Vol 21, Iss 1, Pp 1-8 (2021)
Abstract Background Charcot-Marie-Tooth 1C (CMT1C) is a rare form of dominantly inherited CMT1 neuropathy caused by a mutated gene encoding lipopolysaccharide-induced tumour necrosis alpha factor (LITAF). Case presentation We report a 56-year-old pat
Externí odkaz:
https://doaj.org/article/f1d49a1d34274345bce22bf73acd3991
Autor:
Petra Hnilicova, Ema Kantorova, Stanislav Sutovsky, Milan Grofik, Kamil Zelenak, Egon Kurca, Norbert Zilka, Petra Parvanovova, Martin Kolisek
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 4, p 3325 (2023)
Alzheimer’s disease (AD) is an incurable neurodegenerative disease and the most frequently diagnosed type of dementia, characterized by (1) perturbed cerebral perfusion, vasculature, and cortical metabolism; (2) induced proinflammatory processes; a
Externí odkaz:
https://doaj.org/article/2a9c7cc0534040c98763e47c1781fa7a
Autor:
Frantisek Cibulcik, Peter Spalek, Ivan Martinka, Jana Zidkova, Milan Grofik, Stefan Sivak, Egon Kurca
Publikováno v:
Biomedical Papers, Vol 163, Iss 4, Pp 362-365 (2019)
Background: Paramyotonia congenita is a non-dystrophic myotonia, in which muscle relaxation is delayed after voluntary or evoked contraction. This condition cannot be distinguished on the basis of symptoms and signs alone. It requires consideration o
Externí odkaz:
https://doaj.org/article/86c3034d67154cdd93c1401cd8b76676
Autor:
Michal Cibulka, Maria Brodnanova, Marian Grendar, Jan Necpal, Jan Benetin, Vladimir Han, Egon Kurca, Vladimir Nosal, Matej Skorvanek, Branislav Vesely, Andrea Stanclova, Zora Lasabova, Zuzana Pös, Tomas Szemes, Stanislav Stuchlik, Milan Grofik, Martin Kolisek
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 3, p 1604 (2022)
SLC41A1 (A1) SNPs rs11240569 and rs823156 are associated with altered risk for Parkinson’s disease (PD), predominantly in Asian populations, and rs708727 has been linked to Alzheimer’s disease (AD). In this study, we have examined a potential ass
Externí odkaz:
https://doaj.org/article/6b1e82e213e6441f8365c6c1c9669d5d
Autor:
Igor Straka, Michal Minar, Milan Grofik, Matej Skorvanek, Veronika Bolekova, Andrea Gazova, Jan Kyselovic, Peter Valkovic
Publikováno v:
Journal of Personalized Medicine, Vol 12, Iss 2, p 179 (2022)
Improvement of adherence to pharmacotherapy in patients with Parkinson’s disease (PD) is a challenge in routine clinical practice. Our study was aimed at the effect of pillbox organizers with alarms improving adherence to pharmacotherapy and its im
Externí odkaz:
https://doaj.org/article/d24aeeb111d44ea09dff501242aac40f
Autor:
František Cibulcik, Jan Benetin, Egon Kurca, Milan Grofik, Miloslav Dvorak, Denis Richter, Vladimir Donath, Jan Kothaj, Michal Minar, Peter Valkovic
Publikováno v:
Biomedical Papers, Vol 160, Iss 4, Pp 549-552 (2016)
Aims: Freezing of gait is a disabling symptom in advanced Parkinson's disease. Positive effects have been suggested with MAO-B inhibitors. We report on an open label clinical study on the efficacy of rasagiline as add-on therapy on freezing of gait a
Externí odkaz:
https://doaj.org/article/511cfe65c72d4f668bf47a345f017e92
Autor:
Igor Straka, Michal Minár, Matej Škorvánek, Milan Grofik, Katarína Danterová, Ján Benetin, Egon Kurča, Andrea Gažová, Veronika Boleková, Kathryn A. Wyman-Chick, Ján Kyselovič, Peter Valkovič
Publikováno v:
Frontiers in Neurology, Vol 10 (2019)
Background: Once-daily treatment formulation is associated with better adherence in comparison to more complex medication regimens. The study aimed to detect the extent of adherence to pharmacotherapy in Parkinson disease (PD) patients who take a min
Externí odkaz:
https://doaj.org/article/acc1f572ea014b36a3390cc5112c38fb
Autor:
Michal Cibulka, Maria Brodnanova, Marian Grendar, Milan Grofik, Egon Kurca, Ivana Pilchova, Oto Osina, Zuzana Tatarkova, Dusan Dobrota, Martin Kolisek
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 19, p 4688 (2019)
Gene SLC41A1 (A1) is localized within Parkinson’s disease-(PD)-susceptibility locus PARK16 and encodes for the Na+/Mg2+-exchanger. The association of several A1 SNPs with PD has been studied. Two, rs11240569 and rs823156, have been associated with
Externí odkaz:
https://doaj.org/article/8280183551f24267a64db0bbf377808d