Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Milan Fernando"'
Autor:
Adrian Westhaus, Steven S. Eamegdool, Milan Fernando, Paula Fuller-Carter, Alicia A. Brunet, Annie L. Miller, Rabab Rashwan, Maddison Knight, Maciej Daniszewski, Grace E. Lidgerwood, Alice Pébay, Alex Hewitt, Giorgia Santilli, Adrian J. Thrasher, Livia S. Carvalho, Anai Gonzalez-Cordero, Robyn V. Jamieson, Leszek Lisowski
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract Adeno-associated viral (AAV) vector-mediated retinal gene therapy is an active field of both pre-clinical as well as clinical research. As with other gene therapy clinical targets, novel bioengineered AAV variants developed by directed evolu
Externí odkaz:
https://doaj.org/article/c01c7ea263f948d68832145c2e5bdb19
Autor:
Carissa Chen, Scott Lee, Katherine G. Zyner, Milan Fernando, Victoria Nemeruck, Emilie Wong, Lee L. Marshall, Jesse R. Wark, Nader Aryamanesh, Patrick P.L. Tam, Mark E. Graham, Anai Gonzalez-Cordero, Pengyi Yang
Publikováno v:
Cell Reports, Vol 43, Iss 5, Pp 114219- (2024)
Summary: Defining the molecular networks orchestrating human brain formation is crucial for understanding neurodevelopment and neurological disorders. Challenges in acquiring early brain tissue have incentivized the use of three-dimensional human plu
Externí odkaz:
https://doaj.org/article/8a7fd637d50344138b8dbe6664cdb3e7
Autor:
Joana Ribeiro, Christopher A. Procyk, Emma L. West, Michelle O’Hara-Wright, Monica F. Martins, Majid Moshtagh Khorasani, Aura Hare, Mark Basche, Milan Fernando, Debbie Goh, Neeraj Jumbo, Matteo Rizzi, Kate Powell, Menahil Tariq, Michel Michaelides, James W.B. Bainbridge, Alexander J. Smith, Rachael A. Pearson, Anai Gonzalez-Cordero, Robin R. Ali
Publikováno v:
Cell Reports, Vol 35, Iss 3, Pp 109022- (2021)
Summary: Age-related macular degeneration and other macular diseases result in the loss of light-sensing cone photoreceptors, causing irreversible sight impairment. Photoreceptor replacement may restore vision by transplanting healthy cells, which mu
Externí odkaz:
https://doaj.org/article/f2a1aa9c1fb544b5b5376bb03b90e605
Autor:
Benjamin M. Nash, To Ha Loi, Milan Fernando, Amin Sabri, James Robinson, Anson Cheng, Steven S. Eamegdool, Elizabeth Farnsworth, Bruce Bennetts, John R. Grigg, Seo-Kyung Chung, Anai Gonzalez-Cordero, Robyn V. Jamieson
Publikováno v:
Stem Cells International, Vol 2021 (2021)
Human induced pluripotent stem cells (hiPSCs) generated from patients and the derivative retinal cells enable the investigation of pathological and novel variants in relevant cell populations. Biallelic pathogenic variants in RPE65 cause early-onset
Externí odkaz:
https://doaj.org/article/efc0b3e3faab4cc08d30e555d2e914e1
Autor:
Patrick Ovando-Roche, Emma L. West, Matthew J. Branch, Robert D. Sampson, Milan Fernando, Peter Munro, Anastasios Georgiadis, Matteo Rizzi, Magdalena Kloc, Arifa Naeem, Joana Ribeiro, Alexander J. Smith, Anai Gonzalez-Cordero, Robin R. Ali
Publikováno v:
Stem Cell Research & Therapy, Vol 9, Iss 1, Pp 1-14 (2018)
Abstract Background The use of human pluripotent stem cell-derived retinal cells for cell therapy strategies and disease modelling relies on the ability to obtain healthy and organised retinal tissue in sufficient quantities. Generating such tissue i
Externí odkaz:
https://doaj.org/article/8cabbf931a364048830c83f3d92ee7ad
Autor:
Anai Gonzalez-Cordero, Kamil Kruczek, Arifa Naeem, Milan Fernando, Magdalena Kloc, Joana Ribeiro, Debbie Goh, Yanai Duran, Samuel J.I. Blackford, Laura Abelleira-Hervas, Robert D. Sampson, Ian O. Shum, Matthew J. Branch, Peter J. Gardner, Jane C. Sowden, James W.B. Bainbridge, Alexander J. Smith, Emma L. West, Rachael A. Pearson, Robin R. Ali
Publikováno v:
Stem Cell Reports, Vol 9, Iss 3, Pp 820-837 (2017)
Transplantation of rod photoreceptors, derived either from neonatal retinae or pluripotent stem cells (PSCs), can restore rod-mediated visual function in murine models of inherited blindness. However, humans depend more upon cone photoreceptors that
Externí odkaz:
https://doaj.org/article/8a49ca1b0cdf4a038147dab24006d255
Autor:
Luna, Leandro H., Parra, Roberto C., Garizoain, Gonzalo, Rodríguez, Pablo A., Sebastián Giannotti, P., Mansegosa, Daniela, Baccino, Eric, Ubelaker, Douglas H., Martrille, Laurent, Moraitis, Konstantinos, Zorba, Eleni, Mishra, Manusmrati, Retamal, Rodrigo, Franco, Ademir, Miamoto, Paulo, Baz, Andrea, Camarasa, Frederic, Condori, Lucio, Escalante-Flórez, Karen, Flores, Carmen Hernández, Peccerelli, Fredy, Retana-Milán, Fernando, Rinaldo, Natascia, Rivera, Claudia, Valderrama-Leal, Clara, Adalian, Pascal, Aranda, Claudia M.
Publikováno v:
In Forensic Science International November 2024 364
Autor:
Milan Fernando, Scott Lee, Jesse R. Wark, Di Xiao, Benjamin Y. Lim, Michelle O’Hara-Wright, Hani J. Kim, Grady C. Smith, Ted Wong, Erdahl T. Teber, Robin R. Ali, Pengyi Yang, Mark E. Graham, Anai Gonzalez-Cordero
Publikováno v:
Stem Cell Reports. 17:1476-1492
Advances in the study of neurological conditions have been possible because of pluripotent stem cell technologies and organoids. Studies have described the generation of neural ectoderm-derived retinal and brain structures from pluripotent stem cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c89b49c6deb532647f40ad398e1fc06d
https://doi.org/10.1016/j.stemcr.2022.04.003
https://doi.org/10.1016/j.stemcr.2022.04.003
Autor:
Emma L. West, Paromita Majumder, Arifa Naeem, Milan Fernando, Michelle O'Hara-Wright, Emily Lanning, Magdalena Kloc, Joana Ribeiro, Patrick Ovando-Roche, Ian O. Shum, Neeraj Jumbu, Robert Sampson, Matt Hayes, James W.B. Bainbridge, Anastasios Georgiadis, Alexander J. Smith, Anai Gonzalez-Cordero, Robin R. Ali
Publikováno v:
Stem Cell Reports. 17:775-788
The generation of retinal organoids from human pluripotent stem cells (hPSC) is now a well-established process that in part recapitulates retinal development. However, hPSC-derived photoreceptors that exhibit well-organized outer segment structures h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98516c457b6559e67aa0151915b299fe
https://doi.org/10.1016/j.stemcr.2022.02.019
https://doi.org/10.1016/j.stemcr.2022.02.019
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