Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Milan Fábry"'
Autor:
Joni Vuorio, Jana Škerlová, Milan Fábry, Václav Veverka, Ilpo Vattulainen, Pavlína Řezáčová, Hector Martinez-Seara
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract While DNA encodes protein structure, glycans provide a complementary layer of information to protein function. As a prime example of the significance of glycans, the ability of the cell surface receptor CD44 to bind its ligand, hyaluronan, i
Externí odkaz:
https://doaj.org/article/990ff85791054a3e937ff2ae25de0092
Autor:
Michael Kugler, Josef Holub, Jiří Brynda, Klára Pospíšilová, Suzan El Anwar, Dmytro Bavol, Miroslav Havránek, Vlastimil Král, Milan Fábry, Bohumír Grüner, Pavlína Řezáčová
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 1800-1810 (2020)
Human carbonic anhydrase IX (CA IX), a protein specifically expressed on the surface of solid tumour cells, represents a validated target both for anticancer therapy and diagnostics. We recently identified sulfonamide dicarbaboranes as promising inhi
Externí odkaz:
https://doaj.org/article/4e570bd3c5e44b59a3ffde6f4d2e255b
Autor:
Klára Pospíšilová, Tomáš Knedlík, Pavel Šácha, Libor Kostka, Jiří Schimer, Jiří Brynda, Vlastimil Král, Petr Cígler, Václav Navrátil, Tomáš Etrych, Vladimír Šubr, Michael Kugler, Milan Fábry, Pavlína Řezáčová, Jan Konvalinka
Publikováno v:
ACS Omega, Vol 4, Iss 4, Pp 6746-6756 (2019)
Externí odkaz:
https://doaj.org/article/f19d4dce08f848dba46628cafbb8c70d
Autor:
Barbora Kalousková, Ondřej Skořepa, Denis Cmunt, Celeste Abreu, Kateřina Krejčová, Jan Bláha, Irena Sieglová, Vlastimil Král, Milan Fábry, Robert Pola, Michal Pechar, Ondřej Vaněk
Publikováno v:
Biomedicines, Vol 9, Iss 11, p 1597 (2021)
Targeted cancer immunotherapy is a promising tool for restoring immune surveillance and eradicating cancer cells. Hydrophilic polymers modified with coiled coil peptide tags can be used as universal carriers designed for cell-specific delivery of suc
Externí odkaz:
https://doaj.org/article/2c9043d3a1e7484f806ef4bdcff6e30e
Autor:
Jan Skácel, Stefan Djukic, Ondřej Baszczyňski, Filip Kalčic, Tadeáš Bílek, Karel Chalupský, Jaroslav Kozák, Alexandra Dvořáková, Eva Tloušt’ová, Zuzana Král’ová, Markéta Šmídková, Jan Voldřich, Michaela Rumlová, Petr Pachl, Jiří Brynda, Tereza Vučková, Milan Fábry, Jan Snášel, Iva Pichová, Pavlína Řezáčová, Helena Mertlíková-Kaiserová, Zlatko Janeba
Publikováno v:
Journal of Medicinal Chemistry. 66:6652-6681
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::316a4b6200a65e0c79fc08dfbb8b4688
https://doi.org/10.1021/acs.jmedchem.2c02097
https://doi.org/10.1021/acs.jmedchem.2c02097
Publikováno v:
Acta Crystallographica Section D Structural Biology. 77:1411-1424
The SorC/DeoR family is a large family of bacterial transcription regulators that are involved in the control of carbohydrate metabolism and quorum sensing. To understand the structural basis of DNA recognition, structural studies of two functionally
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4f3dc4e50c5a15b2e6c2063329d4e9b
https://doi.org/10.1107/s2059798321009633
https://doi.org/10.1107/s2059798321009633
Autor:
Eric A. Smith, Zeger Debyser, Vaclav Veverka, Marcela Mádlíková, Milan Fábry, M. Horejsi, Seth R. Goldman, Vanda Lux, Monika Nedomova, H. Courtney Hodges, Pavel Srb, Jan De Rijck, Karen Adelman, Jonas Demeulemeester, Rozálie Hexnerová, Katerina Cermakova
Publikováno v:
Science
Organized by unstructured motifs The high degree of conservation in protein sequences thought to be unstructured has hinted that these regions may have important biological functions. Although unstructured regions are widely viewed to be crucial for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c568e193dc8dcfef56eca62617fab1ae
https://europepmc.org/articles/PMC8943916/
https://europepmc.org/articles/PMC8943916/
Autor:
Anja Muždalo, Katarína Mitrová, Irena Selicharová, Ondřej Socha, Miloš Buděšínský, Pavlo Potalitsyn, Jelena Radosavljević, Michaela Černeková, Milan Fábry, Martina Chrudinová, Lenka Žáková, Jingjing Lin, Martin Lepšík, Kateřina Hanková, Kateřina Macháčková, Květoslava Mlčochová, Jiří Jiráček, Pavel Hobza, Yevgen P. Yurenko
Publikováno v:
The Journal of Biological Chemistry
Information on how insulin and insulin-like growth factors 1 and 2 (IGF-1 and -2) activate insulin receptors (IR-A and -B) and the IGF-1 receptor (IGF-1R) is crucial for understanding the difference in the biological activities of these peptide hormo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be5f6b2d254800e87537349d6ef9761c
https://doi.org/10.1074/jbc.ra119.010072
https://doi.org/10.1074/jbc.ra119.010072
Autor:
Soňa Gurská, Bohumír Grüner, Jana Štěpánková, Marian Hajduch, K. Pospisilova, Alice Nova, Pavlína Řezáčová, Václav Šícha, Milan Fábry, Vlastimil Mašek, Petr Džubák, Stanislava Matějková, Jan Nekvinda, Petr Pachl, Josef Holub, Viswanath Das, Jiří Brynda, Barbora Lišková, Martina Medvedíková, Vlastimil Král, M. Kugler
Publikováno v:
Journal of Medicinal Chemistry. 62:9560-9575
Carbonic anhydrase IX (CAIX) is a transmembrane enzyme that regulates pH in hypoxic tumors and promotes tumor cell survival. Its expression is associated with the occurrence of metastases and poor prognosis. Here, we present nine derivatives of the c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84ed48e61de08139656b184ea62fe554
https://doi.org/10.1021/acs.jmedchem.9b00945
https://doi.org/10.1021/acs.jmedchem.9b00945
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 1867:376-381
Germline mutations in NUDT15 cause thiopurine intolerance during treatment of leukemia or autoimmune diseases. Previously, it has been shown that the mutations affect the enzymatic activity of the NUDT15 hydrolase due to decreased protein stability i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a6ef466f70a59c58a953b57b0fb7ecf
https://doi.org/10.1016/j.bbapap.2019.01.006
https://doi.org/10.1016/j.bbapap.2019.01.006