Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Milan Bruncko"'
Autor:
Anuradha Kumar, Somsundaram Chettiar, Brian S. Brown, Julie Early, Juliane Ollinger, Megan Files, Mai A. Bailey, Aaron Korkegian, Devon Dennison, Matthew McNeil, James Metz, Augustine Osuma, Michael Curtin, Aaron Kunzer, Gail Freiberg, Milan Bruncko, Dale Kempf, Tanya Parish
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-27 (2022)
Abstract We performed a high-throughput phenotypic whole cell screen of Mycobacterium tuberculosis against a diverse chemical library of approximately 100,000 compounds from the AbbVie corporate collection and identified 24 chemotypes with anti-tuber
Externí odkaz:
https://doaj.org/article/a7bda231d18f419a8fd60f4ebad065f6
Autor:
Darren C. Phillips, Joel D. Leverson, Andrew J. Souers, Steven W. Elmore, William N. Pappano, Lisa Roberts-Rapp, Xin Lu, Paul Hessler, Milan Bruncko, George S. Sheppard, Paul Nimmer, Yu Xiao
Supplemental Figure 2: The susceptibility of breast cancer cell lines to MCL-1 siRNA according to genotype and expression of BCL-2 family members.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::698cc98368485a4cf5a4ddd38b33f7ba
https://doi.org/10.1158/1535-7163.22501659
https://doi.org/10.1158/1535-7163.22501659
Autor:
Darren C. Phillips, Joel D. Leverson, Andrew J. Souers, Steven W. Elmore, William N. Pappano, Lisa Roberts-Rapp, Xin Lu, Paul Hessler, Milan Bruncko, George S. Sheppard, Paul Nimmer, Yu Xiao
Supplemental Figure 3: MCL-1 dependency dictates cellular response to the CDK9 inhibitor flavopiridol and correlates with kinetics of death resulting from MCL-1 siRNA treatment.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::177c95a199ffdd6cfd18bc12327ac0f5
https://doi.org/10.1158/1535-7163.22501656.v1
https://doi.org/10.1158/1535-7163.22501656.v1
Autor:
Darren C. Phillips, Joel D. Leverson, Andrew J. Souers, Steven W. Elmore, William N. Pappano, Lisa Roberts-Rapp, Xin Lu, Paul Hessler, Milan Bruncko, George S. Sheppard, Paul Nimmer, Yu Xiao
Supplemental Figure 4: BCL-XL but not BCL-2 gene silencing sensitize HCC-1806 cells to A-1210477-induced apoptosis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18fd678b4e862617129319239cedcfda
https://doi.org/10.1158/1535-7163.22501653
https://doi.org/10.1158/1535-7163.22501653
Autor:
Darren C. Phillips, Joel D. Leverson, Andrew J. Souers, Steven W. Elmore, William N. Pappano, Lisa Roberts-Rapp, Xin Lu, Paul Hessler, Milan Bruncko, George S. Sheppard, Paul Nimmer, Yu Xiao
List of Supplementary Figure Legends. Figure legend information.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::866e8312dc8bd341b6745fa481fac8ca
https://doi.org/10.1158/1535-7163.22501665
https://doi.org/10.1158/1535-7163.22501665
Autor:
Darren C. Phillips, Joel D. Leverson, Andrew J. Souers, Steven W. Elmore, William N. Pappano, Lisa Roberts-Rapp, Xin Lu, Paul Hessler, Milan Bruncko, George S. Sheppard, Paul Nimmer, Yu Xiao
Supplemental Figure 5: Flavopiridol synergizes with navitoclax in breast cancer cell lines in vitro.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::885c2fdb3dd263312f42878db4c1dee2
https://doi.org/10.1158/1535-7163.22501650.v1
https://doi.org/10.1158/1535-7163.22501650.v1
Autor:
Darren C. Phillips, Joel D. Leverson, Andrew J. Souers, Steven W. Elmore, William N. Pappano, Lisa Roberts-Rapp, Xin Lu, Paul Hessler, Milan Bruncko, George S. Sheppard, Paul Nimmer, Yu Xiao
Supplemental Table 1: Viability of breast cancer cell lines treated with PBS, scrambled siRNA (Sc; 20nMol) or MCL-1 siRNA (20nMol) for 72hrs compared to non-treated cells with associated genomic info.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8a28b632d7ac78c4f037fe9c9398014
https://doi.org/10.1158/1535-7163.22501647
https://doi.org/10.1158/1535-7163.22501647
Autor:
Darren C. Phillips, Joel D. Leverson, Andrew J. Souers, Steven W. Elmore, William N. Pappano, Lisa Roberts-Rapp, Xin Lu, Paul Hessler, Milan Bruncko, George S. Sheppard, Paul Nimmer, Yu Xiao
Supplemental Figure 1: Validation of MCL-1 siRNA.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b272f2198d8a0666ffc4c9978ba676d
https://doi.org/10.1158/1535-7163.22501662.v1
https://doi.org/10.1158/1535-7163.22501662.v1
Autor:
Darren C. Phillips, Joel D. Leverson, Andrew J. Souers, Steven W. Elmore, William N. Pappano, Lisa Roberts-Rapp, Xin Lu, Paul Hessler, Milan Bruncko, George S. Sheppard, Paul Nimmer, Yu Xiao
Supplemental Table 2: Navitoclax EC50s in breast cancer cell lines in the presence or absence of MCL-1 siRNA.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b367a8ced413c4349cd42907ff0dea2
https://doi.org/10.1158/1535-7163.22501644.v1
https://doi.org/10.1158/1535-7163.22501644.v1
Autor:
Steven W. Elmore, Saul H. Rosenberg, Stephen W. Fesik, Haichao Zhang, Robert Warner, Baole Wang, Stephen K. Tahir, Jason Stavropoulos, Wang Shen, Weiguo Qing, Tilman Oltersdorf, Jacqueline M. O'Connor, Paul Nimmer, ShiChung Ng, Hugh Nellans, William McClellan, Kennan Marsh, Mary K. Joseph, Ken Jarvis, David J. Frost, Thomas Deckwirth, Milan Bruncko, Tony Borre, Barbara A. Belli, Joy Bauch, Anatol Oleksijew, Alex R. Shoemaker
Supplementary Table 1 from A Small-Molecule Inhibitor of Bcl-XL Potentiates the Activity of Cytotoxic Drugs In vitro and In vivo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ffdcab05705218f3464129646e1c086
https://doi.org/10.1158/0008-5472.22364780
https://doi.org/10.1158/0008-5472.22364780