Výsledky vyhledávání - "Milan, Vrabel"

Identification of specific carbonic anhydrase inhibitors via in situ click chemistry, phage-display and synthetic peptide libraries: comparison of the methods and structural study

Autor: Michael Kugler, Martin Hadzima, Rastislav Dzijak, Robert Rampmaier, Pavel Srb, Lukáš Vrzal, Zdeněk Voburka, Pavel Majer, Pavlína Řezáčová, Milan Vrabel

Publikováno v: RSC Medicinal Chemistry. 14:144-153

Here we show how different selection methods can be used for the discovery of a selective and potent carbonic anhydrase inhibitors. X-Ray and NMR structural studies were used to reveal the key binding interactions of the inhibitor with the enzyme.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1090d2d3beeb22a660427a793999b362
https://doi.org/10.1039/d2md00330a

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Triazinium Ligation: Bioorthogonal Reaction of N1-alkyl 1,2,4-Triazinium Salts

Autor: Milan Vrabel, Veronika Šlachtová, Simona Bellová, Agustina La-Venia, Juraj Galeta, Martin Dračínský, Karel Chalupský, Helena Mertlíková-Kaiserová, Peter Rukovanský, Rastislav Dzijak

The development of reagents that can selectively react in complex biological media is an important challenge. Here we show that N1-alkylation of 1,2,4-triazines yields the corresponding triazinium salts, which are three orders of magnitude more react

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3c1c48644cfc314998d73c80405b0695
https://doi.org/10.26434/chemrxiv-2023-75pjq

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A Systematic Study of Coumarin–Tetrazine Light‐Up Probes for Bioorthogonal Fluorescence Imaging

Autor: Martin Dračínský, Juraj Galeta, Rastislav Dzijak, Milan Vrabel, Jan Obořil

Publikováno v: Chemistry (Weinheim an Der Bergstrasse, Germany)
Chemistry – A European Journal

Fluorescent probes that light‐up upon reaction with complementary bioorthogonal reagents are superior tools for no‐wash fluorogenic bioimaging applications. In this work, a thorough study is presented on a set of seventeen structurally diverse co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7ac8bee7c05d026484c356c1458a30d
http://europepmc.org/articles/PMC7497033

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Genetic Code Expansion, Protein Expression, and Protein Functionalization in Bacillus subtilis

Autor: Sabine Schneider, Milan Vrabel, Christopher M. Scheidler

Publikováno v: ACS Synthetic Biology. 9:486-493

The site-specific chemical modification of proteins through incorporation of noncanonical amino acids enables diverse applications, such as imaging, probing, and expanding protein functions, as well as to precisely engineer therapeutics. Here we repo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8f41664271b527623211521cf75abecd
https://doi.org/10.1021/acssynbio.9b00458

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4-Sulfamoylphenylalkylamides as Inhibitors of Carbonic Anhydrases Expressed in Vibrio cholerae

Autor: Rosaria Gitto, Claudiu T. Supuran, Federica Bucolo, Andrea Angeli, Francesca Mancuso, Clemente Capasso, Laura De Luca, Milan Vrabel

Publikováno v: ChemMedChem
(2021): 3787–3794. doi:10.1002/cmdc.202100510
info:cnr-pdr/source/autori:Mancuso F.; De Luca L.; Bucolo F.; Vrabel M.; Angeli A.; Capasso C.; Supuran C.T.; Gitto R./titolo:4-Sulfamoylphenylalkylamides as Inhibitors of Carbonic Anhydrases Expressed in Vibrio cholerae/doi:10.1002%2Fcmdc.202100510/rivista:ChemMedChem (Print)/anno:2021/pagina_da:3787/pagina_a:3794/intervallo_pagine:3787–3794/volume

A current issue of antimicrobial therapy is the resistance to treatment with worldwide consequences. Thus, the identification of innovative targets is an intriguing challenge in the drug and development process aimed at newer antimicrobial agents. Th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea3c61facd3bba76b065988f1bfa0c1f
https://pubmed.ncbi.nlm.nih.gov/34592052

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Akademický článek

Structural basis for the site-specific incorporation of lysine derivatives into proteins.

Autor: Veronika Flügel, Milan Vrabel, Sabine Schneider

Publikováno v: PLoS ONE, Vol 9, Iss 4, p e96198 (2014)

Posttranslational modifications (PTMs) of proteins determine their structure-function relationships, interaction partners, as well as their fate in the cell and are crucial for many cellular key processes. For instance chromatin structure and hence g

Externí odkaz: https://doaj.org/article/21c0c695a5054c3581627170b22d4422

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An Optimized Protocol for the Synthesis of Peptides Containing trans ‐Cyclooctene and Bicyclononyne Dienophiles as Useful Multifunctional Bioorthogonal Probes

Autor: Agustina La–Venia, Robert Rampmaier, Rastislav Dzijak, Milan Vrabel

Publikováno v: Chemistry – A European Journal

Despite the great advances in solid-phase peptide synthesis (SPPS), the incorporation of certain functional groups into peptide sequences is restricted by the compatibility of the building blocks with conditions used during SPPS. In particular, the i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2123d1a114a8a474e384aaa9f7f49686

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Transition-Metal-Mediated versus Tetrazine-Triggered Bioorthogonal Release Reactions: Direct Comparison and Combinations Thereof

Autor: Helena Mertlíková-Kaiserová, Francesca Mancuso, Rastislav Dzijak, Milan Vrabel, Michal Rahm

Publikováno v: ChemPlusChem. 85(8)

Bioorthogonal cleavage reactions are gaining popularity in chemically inducible prodrug activation and in the control of biomolecular functions. Despite similar applications, these reactions were developed and optimized on different substrates and un

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15ba0e7c45603e1bc49ab55b7de38e6b
https://pubmed.ncbi.nlm.nih.gov/32757364

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