Ineffectiveness of hemoadsorption in large animals with abdominal sepsis: a randomized controlled porcine study

Autor: Vaclav Tegl, Jan Horak, Lukas Nalos, Michala Horakova, Milan Stengl, Martin Matejovic, Jan Benes

Publikováno v: Intensive Care Medicine Experimental, Vol 12, Iss 1, Pp 1-11 (2024)

Abstract Objectives The use of hemoadsorption (HA) has become popular in the treatment of vasoplegic states associated with massive cytokine release, including septic shock. However, this approach does not seem to be based on robust evidence, and it

Externí odkaz: https://doaj.org/article/2c3d9c4cd7f141d59b9b3520bb67950e

Right versus left ventricular remodeling in heart failure due to chronic volume overload

Autor: Tereza Havlenova, Petra Skaroupkova, Matus Miklovic, Matej Behounek, Martin Chmel, Dagmar Jarkovska, Jitka Sviglerova, Milan Stengl, Michal Kolar, Jiri Novotny, Jan Benes, Ludek Cervenka, Jiri Petrak, Vojtech Melenovsky

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)

Abstract Mechanisms of right ventricular (RV) dysfunction in heart failure (HF) are poorly understood. RV response to volume overload (VO), a common contributing factor to HF, is rarely studied. The goal was to identify interventricular differences i

Externí odkaz: https://doaj.org/article/f251e8fd9382404c85c5d930444a3cba

Cellular Mechanisms of Myocardial Depression in Porcine Septic Shock

Autor: Dagmar Jarkovska, Michaela Markova, Jan Horak, Lukas Nalos, Jan Benes, Mahmoud Al-Obeidallah, Zdenek Tuma, Jitka Sviglerova, Jitka Kuncova, Martin Matejovic, Milan Stengl

Publikováno v: Frontiers in Physiology, Vol 9 (2018)

The complex pathogenesis of sepsis and septic shock involves myocardial depression, the pathophysiology of which, however, remains unclear. In this study, cellular mechanisms of myocardial depression were addressed in a clinically relevant, large ani

Externí odkaz: https://doaj.org/article/a0a12b161eb2499fab8ccf8e48c039fe

Right versus left ventricular remodeling in heart failure due to chronic volume overload

Autor: Ludek Cervenka, Martin Chmel, Jan Benes, Petra Škaroupková, Jiri Petrak, Vojtech Melenovsky, Michal Kolar, Matej Behounek, Milan Stengl, Dagmar Jarkovska, Matus Miklovic, Tereza Havlenova, Jiri Novotny, Jitka Sviglerova

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Scientific Reports

Mechanisms of right ventricular (RV) dysfunction in heart failure (HF) are poorly understood. RV response to volume overload (VO), a common contributing factor to HF, is rarely studied. The goal was to identify interventricular differences in respons

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f64e83d2f325562873c8aed04c31eedb
https://doi.org/10.1038/s41598-021-96618-8

Structure-activity relationship and cardiac safety of 2-aryl-2-(pyridin-2-yl)acetamides as a new class of broad-spectrum anticonvulsants derived from Disopyramide

Autor: Bartłomiej Szulczyk, Jules C. Hancox, Jadwiga Turło, Eliska Mistrova, Marek Król, Jitka Sviglerova, Aziza El Harchi, Grzegorz M. Popowicz, Milan Stengl, Piotr Konopelski, Yihong Zhang, Dagmar Jarkovska, Martyna Z. Wróbel, Maciej Dawidowski, Andrzej Chodkowski, Marcin Ufnal, Piotr Szuberski, Piotr Podsadni

Publikováno v: Dawidowski, M, Król, M, Szulczyk, B, Chodkowski, A, Podsadni, P, Konopelski, P, Ufnal, M, Szuberski, P, Wróbel, M Z, Zhang, Y, El Harchi, A, Hancox, J C, Jarkovska, D, Mistrova, E, Sviglerova, J, Štengl, M, Popowicz, G M & Turło, J 2020, ' Structure-activity relationship and cardiac safety of 2-aryl-2-(pyridin-2-yl)acetamides as a new class of broad-spectrum anticonvulsants derived from Disopyramide ', Bioorganic chemistry, vol. 98, 103717 . https://doi.org/10.1016/j.bioorg.2020.103717

A series of 2-aryl-2-(pyridin-2-yl)acetamides were synthesized and screened for their anticonvulsant activity in animal models of epilepsy. The compounds were broadly active in the ‘classical’ maximal electroshock seizure (MES) and subcutaneous M

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6172c64292695f36c4e2860aff66dad
https://research-information.bris.ac.uk/en/publications/4e3ec229-3dad-4d2c-bf42-a6a375ffba4b