The transcription factor Maz is essential for normal eye development

Autor: Jill A. Rosenfeld, Marisol O'Neill, Meade Haller, Olga Medina-Martinez, Dolores J. Lamb, Milan Jamrich

Publikováno v: Disease Models & Mechanisms, Vol 13, Iss 8 (2020)

Wnt/β-catenin signaling plays an essential role in eye development. Faulty regulation of this pathway results in ocular malformations due to defects in cell fate determination and differentiation. Herein we show that disruption of Maz, the gene enco

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67d54dc5c35d23cd7f1d893793848928
http://dmm.biologists.org/content/13/8/dmm044412

Cell-autonomous requirement for rx function in the mammalian retina and posterior pituitary.

Autor: Olga Medina-Martinez, Felipe Amaya-Manzanares, Chaomei Liu, Marisela Mendoza, Rina Shah, Li Zhang, Richard R Behringer, Kathleen A Mahon, Milan Jamrich

Publikováno v: PLoS ONE, Vol 4, Iss 2, p e4513 (2009)

Rx is a paired-like homeobox gene that is required for vertebrate eye formation. Mice lacking Rx function do not develop eyes or the posterior pituitary. To determine whether Rx is required cell autonomously in these tissues, we generated embryonic c

Externí odkaz: https://doaj.org/article/e3f78c156f80476487e4408066d06780

Conditional knockdown of DNA methyltransferase 1 reveals a key role of retinal pigment epithelium integrity in photoreceptor outer segment morphogenesis

Autor: Igor O. Nasonkin, Anand Swaroop, Yun Z. Le, Rivka A. Rachel, Milan Jamrich, Krushangi Patel, Kapil Bharti, Enrique Rodriguez-Boulan, Donald J. Zack, Robert N. Fariss, Kevin Lazo, Matthew Brooks, Verity F. Oliver, Ray Enke, Shannath L. Merbs, Jacob Nellissery

Publikováno v: Development. 140:1330-1341

Dysfunction or death of photoreceptors is the primary cause of vision loss in retinal and macular degenerative diseases. As photoreceptors have an intimate relationship with the retinal pigment epithelium (RPE) for exchange of macromolecules, removal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91fd81f5bd7a26b6a0d28f10baf44757
https://doi.org/10.1242/dev.086603

PALS1 is essential for retinal pigment epithelium structure and neural retina stratification

Autor: B. Park, M. W. Seeliger, Celso H. Alves, Naoyuki Tanimoto, Jan Klooster, Till F. M. Andlauer, A. le Bivic, Eric C. Swindell, Susanne C. Beck, Fabrice Richard, Gesine Huber, Milan Jamrich, Ditte M. S. Lundvig, Jan Wijnholds

Publikováno v: Journal of Neuroscience
Journal of Neuroscience, Society for Neuroscience, 2011, 31 (47), pp.17230-41. ⟨10.1523/JNEUROSCI.4430-11.2011⟩
Journal of Neuroscience; Vol 31
Journal of Neuroscience, 2011, 31 (47), pp.17230-41. ⟨10.1523/JNEUROSCI.4430-11.2011⟩
The Journal of Neuroscience, 31, 17230-17241
The Journal of Neuroscience, 31, pp. 17230-17241
Journal of Neuroscience, 31, 17230-17241. Society for Neuroscience

The membrane-associated palmitoylated protein 5 (MPP5 or PALS1) is thought to organize intracellular PALS1-CRB-MUPP1 protein scaffolds in the retina that are involved in maintenance of photoreceptor–Müller glia cell adhesion. In humans, the Crumbs

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7f774d4c89692e7709ce636bd1a04d2
https://doi.org/10.1523/jneurosci.4430-11.2011

Regulation and function offoxe3 during early zebrafish development

Autor: Eric C. Swindell, Carolyn A. Zilinski, Mary Ellen Lane, Rina Shah, Milan Jamrich, Ryuju Hashimoto

Publikováno v: genesis. 46:177-183

In this article, we investigate the expression, regulation, and function of the zebrafish forkhead gene foxe3. In wild type embryos, foxe3 is first expressed in a crescent-shaped area at the anterior end of the prechordal plate, corresponding to the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da3158c5d4f83180f70748aa2577f642
https://doi.org/10.1002/dvg.20380