Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Milan, Dejmek"'
Autor:
Luca Julianna Tóth, Kateřina Krejčová, Milan Dejmek, Eva Žilecká, Blanka Klepetářová, Lenka Poštová Slavětínská, Evžen Bouřa, Radim Nencka
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 20, Iss 1, Pp 1029-1036 (2024)
The RNA-dependent RNA polymerase (RdRp) represents a prominent target in the discovery and development of new antivirotics against RNA viruses, inhibiting the replication process. One of the most targeted RNA viruses of the last years is, without dou
Externí odkaz:
https://doaj.org/article/236a37cebaa444598c76d0293aeebeff
Publikováno v:
Journal of Structural Biology: X, Vol 10, Iss , Pp 100109- (2024)
Nsp14 is an RNA methyltransferase (MTase) encoded by all coronaviruses. In fact, many viral families, including DNA viruses, encode MTases that catalyze the methylation of the RNA precap structure, resulting in fully capped viral RNA. This capping is
Externí odkaz:
https://doaj.org/article/132271903dc94f2b95a0bfb66c654966
Autor:
Nivedita Sengupta, Marko Jović, Elena Barnaeva, David W. Kim, Xin Hu, Noel Southall, Milan Dejmek, Ivana Mejdrova, Radim Nencka, Adriana Baumlova, Dominika Chalupska, Evzen Boura, Marc Ferrer, Juan Marugan, Tamas Balla
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 3, Pp 683-693 (2019)
The minor phospholipid, phosphatidylinositol 4-phosphate (PI4P), is emerging as a key regulator of lipid transfer in ER-membrane contact sites. Four different phosphatidylinositol 4-kinase (PI4K) enzymes generate PI4P in different membrane compartmen
Externí odkaz:
https://doaj.org/article/140be2b4c8d44d3c8e02d4ac3aa65593
Autor:
Courtney Chambers, Katerina Cermakova, Yuen San Chan, Kristen Kurtz, Katharina Wohlan, Andrew Henry Lewis, Christiana Wang, Anh Pham, Milan Dejmek, Michal Sala, Mario Loeza Cabrera, Rogelio Aguilar, Radim Nencka, H. Daniel Lacorazza, Rachel E. Rau, H. Courtney Hodges
Publikováno v:
Cancer Research. 83:983-996
In acute myeloid leukemia (AML), SWI/SNF chromatin remodeling complexes sustain leukemic identity by driving high levels of MYC. Previous studies have implicated the hematopoietic transcription factor PU.1 (SPI1) as an important target of SWI/SNF inh
Autor:
Milan Dejmek, Andrea Brazdova, Zdenek Vavrina, Petra Břehová, Gabriel Birkus, Lenka Vanekova, Markéta Polidarová
Publikováno v:
ACS Infectious Diseases. 9:23-32
Chronic hepatitis B (CHB) remains a major public health problem worldwide, with limited treatment options, but inducing an antiviral response by innate immunity activation may provide a therapeutic alternative. We assessed the cytokine-mediated anti-
Autor:
Sidney Becker, Christina Schneider, Hidenori Okamura, Antony Crisp, Tynchtyk Amatov, Milan Dejmek, Thomas Carell
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
How RNA building blocks have formed on an early Earth by a continuous process is still a mystery awaiting its solution. Here, the authors report that fluctuations of physical parameters like temperature and pH could have been enough to facilitate nuc
Externí odkaz:
https://doaj.org/article/f30b47cab3884e568cef79fb2ecc6324
Autor:
Zdeněk Vavřina, Pavla Perlíková, Nemanja Milisavljević, Florian Chevrier, Miroslav Smola, Joshua Smith, Milan Dejmek, Vojtěch Havlíček, Miloš Buděšínský, Radek Liboska, Lenka Vaneková, Jiří Brynda, Evzen Boura, Pavlína Řezáčová, Michal Hocek, Gabriel Birkuš
Publikováno v:
Journal of Medicinal Chemistry. 65:14082-14103
Cyclic dinucleotides (CDNs) are second messengers that activate stimulator of interferon genes (STING). The cGAS-STING pathway plays a promising role in cancer immunotherapy. Here, we describe the synthesis of CDNs containing 7-substituted 7-deazapur
Autor:
Milan Dejmek, Eva Konkoľová, Luděk Eyer, Petra Straková, Pavel Svoboda, Michal Šála, Kateřina Krejčová, Daniel Růžek, Evzen Boura, Radim Nencka
Publikováno v:
Viruses, Vol 13, Iss 8, p 1585 (2021)
SARS-CoV-2 has caused an extensive pandemic of COVID-19 all around the world. Key viral enzymes are suitable molecular targets for the development of new antivirals against SARS-CoV-2 which could represent potential treatments of the corresponding di
Externí odkaz:
https://doaj.org/article/3a4d2127737c462d8b5894cb21b9defc
Autor:
H. Courtney Hodges, Rachel E. Rau, H. Daniel Lacorazza, Radim Nencka, Rogelio Aguilar, Mario Loeza Cabrera, Michal Sala, Milan Dejmek, Anh Pham, Christiana Wang, Andrew Henry Lewis, Katharina Wohlan, Kristen Kurtz, Yuen San Chan, Katerina Cermakova, Courtney Chambers
Supplementary Materials
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42cb047ddab86b1b962b42e21c8ce8a8
https://doi.org/10.1158/0008-5472.22549670.v1
https://doi.org/10.1158/0008-5472.22549670.v1
Autor:
H. Courtney Hodges, Rachel E. Rau, H. Daniel Lacorazza, Radim Nencka, Rogelio Aguilar, Mario Loeza Cabrera, Michal Sala, Milan Dejmek, Anh Pham, Christiana Wang, Andrew Henry Lewis, Katharina Wohlan, Kristen Kurtz, Yuen San Chan, Katerina Cermakova, Courtney Chambers
Motif profiling
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::034e88327dc89c967389d1e7b7dd2f37
https://doi.org/10.1158/0008-5472.22361380.v1
https://doi.org/10.1158/0008-5472.22361380.v1