A New Guanidine-Core Small-Molecule Compound as a Potential Antimicrobial Agent against Resistant Bacterial Strains

Autor: Noelia Morata-Moreno, Ramón Pérez-Tanoira, Almudena del Campo-Balguerias, Fernando Carrillo-Hermosilla, Marcos Hernando-Gozalo, Carlos Rescalvo-Casas, Ana V. Ocana, Pedro Segui, Carlos Alonso-Moreno, Francisco C. Pérez-Martínez, Milagros Molina-Alarcón

Publikováno v: Antibiotics, Vol 13, Iss 7, p 609 (2024)

The guanidine core has been one of the most studied functional groups in medicinal chemistry, and guanylation reactions are powerful tools for synthesizing this kind of compound. In this study, a series of five guanidine-core small molecules were obt

Externí odkaz: https://doaj.org/article/9d72fc4c5d2a434186f9f14fa777dea3

Relationship between Motor and Nonmotor Symptoms and Quality of Life in Patients with Parkinson’s Disease

Autor: Eduardo Candel-Parra, María Pilar Córcoles-Jiménez, Victoria Delicado-Useros, Antonio Hernández-Martínez, Milagros Molina-Alarcón

Publikováno v: Nursing Reports, Vol 12, Iss 1, Pp 1-12 (2021)

Background: Parkinson’s disease (PD) is a chronic neurodegenerative disease that implies a progressive and invalidating functional organic disorder, which continues to evolve till the end of life and causes different mental and physical alterations

Externí odkaz: https://doaj.org/article/5588c17525dc4c1cb0d68b18fcacd818

Methacrylate Cationic Nanoparticles Activity against Different Gram-Positive Bacteria

Autor: Syong H. Nam-Cha, Ana V. Ocaña, Ramón Pérez-Tanoira, John J. Aguilera-Correa, Abraham J. Domb, Marta C. Ruiz-Grao, Sandra Cebada-Sánchez, Ángel López-Gónzalez, Milagros Molina-Alarcón, Juan Pérez-Martínez, Francisco C. Pérez-Martínez

Publikováno v: Antibiotics, Vol 12, Iss 3, p 533 (2023)

Nanotechnology is a developing field that has boomed in recent years due to the multiple qualities of nanoparticles (NPs), one of which is their antimicrobial capacity. We propose that NPs anchored with 2-(dimethylamino)ethyl methacrylate (DMAEMA) ha

Externí odkaz: https://doaj.org/article/ee575e6a8c684adf8eeb8bafcbc17901

Frailty, depression risk and 10-year hospitalization in older adults. The FRADEA study

Autor: Marta Carolina Ruiz-Grao, Pedro Manuel Sánchez-Jurado, Milagros Molina-Alarcón, Miriam Garrido-Miguel, Celia Álvarez-Bueno, Rubén Alcantud-Córcoles, Fernando Andrés-Petrel, Almudena Avendaño-Céspedes, Cristina Gómez-Ballesteros, Victoria Sánchez-Flor- Alfaro, Rita López-Bru, Belén Roldán-García, María Teresa Tabernero-Sahuquillo, Marta Mas-Romero, Rafael García-Molina, Luis Romero-Rizos, Pedro Abizanda

Publikováno v: Geriatric Nursing. 46:184-190

To determine whether the interaction between frailty status and depression risk is associated with hospitalization density in older adults.Ongoing cohort study in 794 subjects aged over 70 years from Albacete (Spain). Data were collected on depressio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b988e927a79d9f7ca1b3b6e3214e7b1
https://doi.org/10.1016/j.gerinurse.2022.05.015

A novel bis(pyrazolyl)methane compound as a potential agent against Gram-positive bacteria

Autor: Milagros Molina-Alarcón, Ramón Pérez-Tanoira, Ana V. Ocaña, Antonio Marcilla, Pedro Seguí, Francisco C. Pérez-Martínez, J J Aguilera-Correa, José A. Castro-Osma, Jaime Esteban, Christian M. Sánchez-López, Elena Domínguez-Jurado, Carlos Alonso-Moreno

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
SCIENTIFIC REPORTS
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
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Scientific Reports

This study was designed to propose alternative therapeutic compounds to fight against bacterial pathogens. Thus, a library of nitrogen-based compounds bis(triazolyl)methane (1T–7T) and bis(pyrazolyl)methane (1P–11P) was synthesised following prev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::feb16cfa9320fea871ec5cc99530a089
https://doaj.org/article/d7cf4a045fdd4394aaba1c44da275b66