Zobrazeno 1 - 10
of 211
pro vyhledávání: '"Milagros Medina"'
Autor:
Andrea Curtabbi, Adela Guarás, José Luis Cabrera-Alarcón, Maribel Rivero, Enrique Calvo, Marina Rosa-Moreno, Jesús Vázquez, Milagros Medina, José Antonio Enríquez
Publikováno v:
Redox Biology, Vol 69, Iss , Pp 103001- (2024)
Respiratory complex I plays a crucial role in the mitochondrial electron transport chain and shows promise as a therapeutic target for various human diseases. While most studies focus on inhibiting complex I at the Q-site, little is known about inhib
Externí odkaz:
https://doaj.org/article/a71adee731ca4f05938fc739793e0634
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 6, p 3174 (2024)
Enzymes reliant on pyridoxal 5′-phosphate (PLP), the metabolically active form of vitamin B6, hold significant importance in both biology and medicine. They facilitate various biochemical reactions, particularly in amino acid and neurotransmitter m
Externí odkaz:
https://doaj.org/article/22fa1166384b451194c43e92eaf09590
Autor:
Guido M. Rey Valzacchi, Diego Odetto, José M. Saadi, Liliana B. Zamora, Candela Loza, Milagros Medina, Myriam B. Perrotta
Publikováno v:
Gynecologic Oncology Reports, Vol 48, Iss , Pp 101226- (2023)
Objective: To report the surgical, oncological, and obstetrical outcomes of the different surgical techniques used for the fertility-sparing treatment of patients with early-stage cervical cancer. Methods: We retrospectively analyzed all fertility-sp
Externí odkaz:
https://doaj.org/article/d47e49030e604209a64fc2d8aeecd2d9
Autor:
Maribel Rivero, Sergio Boneta, Nerea Novo, Adrián Velázquez-Campoy, Victor Polo, Milagros Medina
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
Enzymes catalysing sequential reactions have developed different mechanisms to control the transport and flux of reactants and intermediates along metabolic pathways, which usually involve direct transfer of metabolites from an enzyme to the next one
Externí odkaz:
https://doaj.org/article/b3b4c3d508e342e6a63fd3bd62e04808
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 2 (2022)
ABSTRACT Flavoproteins are a diverse class of proteins that are mostly enzymes and contain as cofactors flavin mononucleotide (FMN) and/or flavin adenine dinucleotide (FAD), which enable them to participate in a wide range of physiological reactions.
Externí odkaz:
https://doaj.org/article/1e54e246544343d58f57dae7ade8f1dd
Autor:
Juan Luis Pacheco-Garcia, Ernesto Anoz-Carbonell, Pavla Vankova, Adithi Kannan, Rogelio Palomino-Morales, Noel Mesa-Torres, Eduardo Salido, Petr Man, Milagros Medina, Athi N. Naganathan, Angel L. Pey
Publikováno v:
Redox Biology, Vol 46, Iss , Pp 102112- (2021)
The multifunctional nature of human flavoproteins is critically linked to their ability to populate multiple conformational states. Ligand binding, post-translational modifications and disease-associated mutations can reshape this functional landscap
Externí odkaz:
https://doaj.org/article/d49adeee3e97449fb1fdc18c33294f37
Autor:
Juan Luis Pacheco-Garcia, Dmitry S. Loginov, Ernesto Anoz-Carbonell, Pavla Vankova, Rogelio Palomino-Morales, Eduardo Salido, Petr Man, Milagros Medina, Athi N. Naganathan, Angel L. Pey
Publikováno v:
Antioxidants, Vol 11, Iss 6, p 1110 (2022)
Allosterism is a common phenomenon in protein biochemistry that allows rapid regulation of protein stability; dynamics and function. However, the mechanisms by which allosterism occurs (by mutations or post-translational modifications (PTMs)) may be
Externí odkaz:
https://doaj.org/article/b95e67435a8a43c0af026892a8aef1b0
Autor:
Candela Agustina Loza, Milagros Medina
Publikováno v:
Evidencia. Actualización en la Práctica Ambulatoria, Vol 23, Iss 4 (2020)
Uno de los efectos adversos que generan mayor impacto psicosocial en los pacientes que se someten a quimioterapia es la pérdida de cabello. El uso de los cascos fríos podría representar una alternativa para prevenir la alopecia. Estos dispositivos
Externí odkaz:
https://doaj.org/article/2271ab9b49734c80a68b517b58e62914
Autor:
Sandra Pérez-Domínguez, Silvia Caballero-Mancebo, Carlos Marcuello, Marta Martínez-Júlvez, Milagros Medina, Anabel Lostao
Publikováno v:
Antioxidants, Vol 11, Iss 3, p 537 (2022)
Plastidic ferredoxin-NADP+ reductase (FNR) transfers two electrons from two ferredoxin or flavodoxin molecules to NADP+, generating NADPH. The forces holding the Anabaena FNR:NADP+ complex were analyzed by dynamic force spectroscopy, using WT FNR and
Externí odkaz:
https://doaj.org/article/05629ef13390484ca107c0df7a624f64
Autor:
Isaias Lans, Ernesto Anoz-Carbonell, Karen Palacio-Rodríguez, José Antonio Aínsa, Milagros Medina, Pilar Cossio
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 8, p e1007898 (2020)
New treatments for diseases caused by antimicrobial-resistant microorganisms can be developed by identifying unexplored therapeutic targets and by designing efficient drug screening protocols. In this study, we have screened a library of compounds to
Externí odkaz:
https://doaj.org/article/efa74053afd34f7b8161b1682466173e