Výsledky vyhledávání - "Milagros C. Romay"

Akademický článek

Regulation of NF-κB signaling by oxidized glycerophospholipid and IL-1β induced miRs-21-3p and -27a-5p in human aortic endothelial cells[S]

Autor: Milagros C. Romay, Nam Che, Scott N. Becker, Delila Pouldar, Raffi Hagopian, Xinshu Xiao, Aldons J. Lusis, Judith A. Berliner, Mete Civelek

Publikováno v: Journal of Lipid Research, Vol 56, Iss 1, Pp 38-50 (2015)

Exposure of endothelial cells (ECs) to agents such as oxidized glycerophospholipids (oxGPs) and cytokines, known to accumulate in atherosclerotic lesions, perturbs the expression of hundreds of genes in ECs involved in inflammatory and other biologic

Externí odkaz: https://doaj.org/article/1f59c493c62f44e49387fa92098d55ba

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Single-cell RNA sequencing to study vascular diversity and function

Autor: Gloria Hernandez, Milagros C. Romay, Feiyang Ma, M. Luisa Iruela-Arispe

Publikováno v: Curr Opin Hematol

Purpose of review Single-cell RNA sequencing (scRNA-seq) can capture the transcriptional profile of thousands of individual cells concurrently from complex tissues and with remarkable resolution. Either with the goal of seeking information about dist

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f1933e938026449b4fffad737286a44
https://doi.org/10.1097/moh.0000000000000651

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Akademický článek

Genetic Dissection of Cardiac Remodeling in an Isoproterenol-Induced Heart Failure Mouse Model.

Autor: Jessica Jen-Chu Wang, Christoph Rau, Rozeta Avetisyan, Shuxun Ren, Milagros C Romay, Gabriel Stolin, Ke Wei Gong, Yibin Wang, Aldons J Lusis

Publikováno v: PLoS Genetics, Vol 12, Iss 7, p e1006038 (2016)

We aimed to understand the genetic control of cardiac remodeling using an isoproterenol-induced heart failure model in mice, which allowed control of confounding factors in an experimental setting. We characterized the changes in cardiac structure an

Externí odkaz: https://doaj.org/article/07894b709ca746889fb3aef9329d6d33

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Positional transcriptomics shed light on site-specific pathologies of the aorta

Autor: Marie Vandestienne, Marcel Blot-Chabaud, Michele Silvestro, Aurélie S. Leroyer, Todd Kimball, Milagros C. Romay, Hafid Ait-Oufella, Gloria Hernandez, Andrew Reyes, Matteo Pellegrini, Feiyang Ma, Bhama Ramkhelawon, Nathalie Bardin, Margaret Ramirez, M. Luisa Iruela-Arispe, Tarik Hadi

Pathologies of large vessels, such as atherosclerosis and aneurysms tend to emerge at specific sites. The consistency in their distribution suggests that a combination of unique local stressors, including both physical forces and specific gene expres

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::43fa96cefd3c3c8309de3f6bc53a4e46
https://doi.org/10.21203/rs.3.rs-951818/v1

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Emerging molecular mechanisms of vascular dementia

Autor: M. Luisa Iruela-Arispe, Milagros C. Romay, Camilo Toro

Publikováno v: Current Opinion in Hematology. 26:199-206

PURPOSE OF THE REVIEW: Microvascular ischemic disease of the brain is a common cause of cognitive impairment and dementia, particularly in the context of preexisting cardiovascular risk factors and aging. This review summarizes our current understand

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73d7b8bdc02f1c24d69e055d8f8501c8
https://doi.org/10.1097/moh.0000000000000502

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Abstract MP144: Identification of Epigenetic Regulators of Cardiac Hypertrophy by an Epigenome-wide Association Study in Mice

Autor: Yibin Wang, Milagros C. Romay, Wilson Lek Wen Tan, Aldons J. Lusis, Christoph Rau, Eleanor Wong, Roger Foo

Publikováno v: Circulation Research. 127

We previously reported a study of heart failure in a large cohort of inbred mouse strains, the Hybrid Mouse Diversity Panel (HMDP), treated with the beta-adrenergic agonist isoproterenol, which identified over 30 genome-wide significant loci for hear

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ddbedfe0cc6dd45a6ac5a7dd2ff1b133
https://doi.org/10.1161/res.127.suppl_1.mp144

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NOTCH1 is a mechanosensor in adult arteries

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-19 (2017)
Nature Communications
Nature communications, vol 8, iss 1
Mack, JJ; Mosqueiro, TS; Archer, BJ; Jones, WM; Sunshine, H; Faas, GC; et al.(2017). NOTCH1 is a mechanosensor in adult arteries. NATURE COMMUNICATIONS, 8. doi: 10.1038/s41467-017-01741-8. UCLA: Retrieved from: http://www.escholarship.org/uc/item/6kp8r7gv

Endothelial cells transduce mechanical forces from blood flow into intracellular signals required for vascular homeostasis. Here we show that endothelial NOTCH1 is responsive to shear stress, and is necessary for the maintenance of junctional integri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a3eaa9fe3bfa845b609d56c6c02509d
http://link.springer.com/article/10.1038/s41467-017-01741-8

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A personalized, multiomics approach identifies genes involved in cardiac hypertrophy and heart failure

Autor: Shuxun Ren, Milagros C. Romay, Marc Santolini, Yibin Wang, Christoph Rau, Jessica Wang, Aldons J. Lusis, Alain Karma, Clara Yukhtman, James N. Weiss, Jeffrey J. Saucerman

Publikováno v: NPJ Systems Biology and Applications
NPJ systems biology and applications, vol 4, iss 1
npj Systems Biology and Applications, Vol 4, Iss 1, Pp 1-13 (2018)

A traditional approach to investigate the genetic basis of complex diseases is to identify genes with a global change in expression between diseased and healthy individuals. However, population heterogeneity may undermine the effort to uncover genes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97d124ac7344a53311f1874e6758bf25
http://europepmc.org/articles/PMC5825397

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