Výsledky vyhledávání - "Milada S, Vala"

Genome-wide comparison of the transcriptomes of highly enriched normal and chronic myeloid leukemia stem and progenitor cell populations

Autor: William G. Nelson, Meltem Gürel, Richard J. Jones, Jessica L. Gucwa, Milada S. Vala, Michael C. Haffner, Jonathan M. Gerber, Srinivasan Yegnasubramanian, David M. Esopi

Publikováno v: Oncotarget

The persistence leukemia stem cells (LSCs) in chronic myeloid leukemia (CML) despite tyrosine kinase inhibition (TKI) may explain relapse after TKI withdrawal. Here we performed genome-wide transcriptome analysis of highly refined CML and normal stem

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86f701d702f27ab345e84d7ab09e00f2
https://doi.org/10.18632/oncotarget.990

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A clinically relevant population of leukemic CD34+CD38− cells in acute myeloid leukemia

Autor: Richard J. Jones, Mark J. Levis, Judith E. Karp, Steven Galkin, B. Douglas Smith, Brandy Perkins, Michael J. Borowitz, Saul J. Sharkis, Laura Morsberger, Milada S. Vala, Constance A. Griffin, Jonathan M. Gerber, Michael I. Collector, Hao Zhang, Brownhilda Ngwang

Publikováno v: Blood. 119:3571-3577

Relapse of acute myeloid leukemia (AML) is thought to reflect the failure of current therapies to adequately target leukemia stem cells (LSCs), the rare, resistant cells presumed responsible for maintenance of the leukemia and typically enriched in t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29fdb55d3af2d88cb6ff66a81b35b8f8
https://doi.org/10.1182/blood-2011-06-364182

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Induction of acute lymphocytic leukemia differentiation by maintenance therapy

Autor: William Matsui, Judith E. Karp, Tara L. Lin, Milada S. Vala, B D Smith, Richard J. Jones, James Barber

Publikováno v: Leukemia. 21:1915-1920

Despite extensive study in many malignancies, maintenance therapy has clinically benefited only two diseases: acute lymphocytic leukemia (ALL) and acute promyelocytic leukemia (APL). ALL maintenance therapy utilizes low-dose 6-mercaptopurine (6MP) an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdc847a0b22baf4a27d1a1d83d25e609
https://doi.org/10.1038/sj.leu.2404823

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Effects of imatinib and interferon on primitive chronic myeloid leukaemia progenitors

Autor: William Matsui, Greg R. Angstreich, Milada S. Vala, James Barber, Anita L. Hawkins, Richard J. Jones, B. Douglas Smith, Constance A. Griffin, Carol Ann Huff

Publikováno v: British Journal of Haematology. 130:373-381

Imatinib has impressive activity against chronic myeloid leukaemia (CML), but does not appear to completely eradicate the disease. Although responses to interferon-alpha (IFN) are slower and less dramatic than those to imatinib, they can be durable e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a3b28d881649d4da2611f12205f4f4e
https://doi.org/10.1111/j.1365-2141.2005.05606.x

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Anti-tumour activity of interferon-alpha in multiple myeloma: role of interleukin 6 and tumor cell differentiation

Autor: Milada S. Vala, Richard J. Jones, B. Douglas Smith, William Matsui, James Barber, Carol Ann Huff

Publikováno v: British Journal of Haematology. 121:251-258

Interferon-alpha (IFN-alpha) is a pleotropic cytokine that has clinical activity against a wide variety of malignancies, including multiple myeloma (MM). In vitro, IFN-alpha has diverse effects on both normal and malignant cells, however, the exact m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::154e26369093c2ab485b08576fb63e63
https://doi.org/10.1046/j.1365-2141.2003.04255.x

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Autologous bone marrow transplantation with 4-hydroperoxycyclophosphamide purging for acute myeloid leukaemia beyond first remission: a 10-year experience

Autor: Don Fuller, S. J. Noga, Richard F. Ambinder, Milada S. Vala, Richard J. Jones, Shing M. Lee, Steven D. Gore, Ian W. Flinn, Carole B. Miller, Ephraim J. Fuchs, Paul O'Donnell, Hayden G. Braine, B. Douglas Smith, S Piantadosi, Georgia B. Vogelsang, Robert A. Brodsky

Publikováno v: British Journal of Haematology. 117:907-913

Summary. Between January 1987 and January 1997, 69 eligible patients with acute myeloid leukaemia (AML) in either second (CR2) or third (CR3) complete remission (CR2 = 60, CR3 = 9) underwent 4-hydroperoxycyclophosphamide-purged autologous bone marrow

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::facb428aee79fd27e472a2936ac06021
https://doi.org/10.1046/j.1365-2141.2002.03530.x

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Inhibited apoptosis and drug resistance in acute myeloid leukaemia

Autor: Barbara Bambach, Philip J. Burke, B. Douglas Smith, James Barber, Cheryl Enger, Robert A. Brodsky, Steven D. Gore, Milada S. Vala, Richard J. Jones

Publikováno v: British Journal of Haematology. 102:1042-1049

Despite extensive investigation into mechanisms of drug resistance in acute myeloid leukaemia (AML), the aetiology of therapeutic resistance is unclear. We found that five leukaemia cell lines (K562, HL-60, CEM. CEM induced to overexpress bcl-2, and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::992b90ab1b4b8b7d68d509ece5c4376a
https://doi.org/10.1046/j.1365-2141.1998.00854.x

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Resistance to apoptosis caused byPIG-Agene mutations in paroxysmal nocturnal hemoglobinuria

Autor: James Barber, Robert A. Brodsky, M. E. Medof, Richard J. Jones, Milada S. Vala

Publikováno v: Proceedings of the National Academy of Sciences. 94:8756-8760

Paroxysmal nocturnal hemoglobinuria (PNH) is a clonal hematopoietic stem cell disorder resulting from mutations in an X-linked gene,PIG-A, that encodes an enzyme required for the first step in the biosynthesis of glycosylphosphatidylinositol (GPI) an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01f96afd3d46bf2e5114441af860fcf0
https://doi.org/10.1073/pnas.94.16.8756

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Characterization of mouse lymphohematopoietic stem cells lacking spleen colony-forming activity

Autor: Milada S. Vala, John Hilton, O M Colvin, Anita L. Hawkins, James Barber, MJ Fackler, WS May, Barbara A. Zehnbauer, Richard J. Jones, Constance A. Griffin, Michael I. Collector, Saul J. Sharkis

Publikováno v: Blood. 88:487-491

The classical definition of lymphohematopoietic stem cells (LHSC), the most primitive progenitors of all blood cells, requires that they have the capacity for self-renewal and for the long-term production of all blood cell lineages. However, other ch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::378927032f9667b4e67d81ae2fbb76ee
https://doi.org/10.1182/blood.v88.2.487.bloodjournal882487

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BCR-ABL-mediated inhibition of apoptosis with delay of G2/M transition after DNA damage: a mechanism of resistance to multiple anticancer agents

Autor: Milada S. Vala, Wafik S. El-Deiry, John Hilton, David Sidransky, Atul Bedi, James Barber, Gauri C. Bedi, Adil J. Akhtar, Richard J. Jones

Publikováno v: Blood. 86:1148-1158

A critical determinant of the efficacy of antineoplastic therapy is the response of malignant cells to DNA damage induced by anticancer agents. The p53 tumor-suppressor gene is a critical component of two distinct cellular responses to DNA damage, th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::769aeee2fcc64056da5ff64da03118b3
https://doi.org/10.1182/blood.v86.3.1148.1148

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