Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Milad Ghomlaghi"'
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Signal processing by intracellular kinases controls near all biological processes but how signal pathway functions evolve with changed cellular context is poorly understood. Functional specificity of c-Jun N-terminal Kinases (JNK) are partly
Externí odkaz:
https://doaj.org/article/287d2d47a12146408d77c44dc16e7549
Autor:
Gideon Kowadlo, Yoel Mittelberg, Milad Ghomlaghi, Daniel K. Stiglitz, Kartik Kishore, Ranjan Guha, Justin Nazareth, Laurence Weinberg
Publikováno v:
BMC Medical Informatics and Decision Making, Vol 24, Iss 1, Pp 1-17 (2024)
Abstract Background Pre-operative risk assessment can help clinicians prepare patients for surgery, reducing the risk of perioperative complications, length of hospital stay, readmission and mortality. Further, it can facilitate collaborative decisio
Externí odkaz:
https://doaj.org/article/b8a7f8c97c5747429f74c597fa5702b7
Autor:
Milad Ghomlaghi, Mandy Theocharous, Nhan Hoang, Sung-Young Shin, Alex von Kriegsheim, Eric O’ Neill, Tao Zhang, Lan K. Nguyen
Publikováno v:
iScience, Vol 27, Iss 3, Pp 109031- (2024)
Summary: The transcriptional co-activator YAP forms complexes with distinct transcription factors, controlling cell fate decisions, such as proliferation and apoptosis. However, the mechanisms underlying its context-dependent function are poorly defi
Externí odkaz:
https://doaj.org/article/ac43d1e023b14adeb764bd7c42e1ff0f
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 9, p e1008513 (2021)
The PI3K/MTOR signalling network regulates a broad array of critical cellular processes, including cell growth, metabolism and autophagy. The mechanistic target of rapamycin (MTOR) kinase functions as a core catalytic subunit in two physically and fu
Externí odkaz:
https://doaj.org/article/712302b6419c4aefa8ed03c345a6d2de
Autor:
Alison L Kearney, Dougall M Norris, Milad Ghomlaghi, Martin Kin Lok Wong, Sean J Humphrey, Luke Carroll, Guang Yang, Kristen C Cooke, Pengyi Yang, Thomas A Geddes, Sungyoung Shin, Daniel J Fazakerley, Lan K Nguyen, David E James, James G Burchfield
Publikováno v:
eLife, Vol 10 (2021)
The phosphoinositide 3-kinase (PI3K)-Akt network is tightly controlled by feedback mechanisms that regulate signal flow and ensure signal fidelity. A rapid overshoot in insulin-stimulated recruitment of Akt to the plasma membrane has previously been
Externí odkaz:
https://doaj.org/article/95b5ee5592d94a12a25916f631425d1d
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 13, p 6944 (2021)
The PI3K/mTOR signalling pathway plays a central role in the governing of cell growth, survival and metabolism. As such, it must integrate and decode information from both external and internal sources to guide efficient decision-making by the cell.
Externí odkaz:
https://doaj.org/article/fa1c862be0c24a4ab01dbc793f9a3717
Autor:
Gideon Kowadlo, Yoel Mittelberg, Milad Ghomlaghi, Daniel Stiglitz, Kartik Kishore, Ranjan Guha, Justin Nazareth, Laurence Weinberg
BackgroundPre-operative risk assessment can help clinicians prepare patients for surgery, reducing the risk of perioperative complications, length of hospital stay, readmission and mortality. Further, it can facilitate collaborative decision-making a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a9f3de0073b6f17723826c955fc37aa
https://doi.org/10.1101/2022.10.03.22280539
https://doi.org/10.1101/2022.10.03.22280539
The Hippo pathway is an evolutionarily conserved signaling network that integrates diverse cues to regulate cell fate and organ homeostasis. The central downstream pathway protein is the transcriptional co-activator Yes-associated protein (YAP). Alth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bca6aa77a925e21dcfa6de604aa2d996
https://doi.org/10.1101/2022.04.06.487403
https://doi.org/10.1101/2022.04.06.487403
Autor:
Sean J. Humphrey, James G. Burchfield, Milad Ghomlaghi, David E. James, Kristen C. Cooke, Thomas A Geddes, Luke Carroll, Guang Yang, Pengyi Yang, Lan K. Nguyen, Sung-Young Shin, Daniel J. Fazakerley, Dougall M. Norris, Martin Kin Lok Wong, Alison L Kearney
Publikováno v:
eLife, Vol 10 (2021)
eLife
eLife
The phosphoinositide 3-kinase (PI3K)-Akt network is tightly controlled by feedback mechanisms that regulate signal flow and ensure signal fidelity. A rapid overshoot in insulin-stimulated recruitment of Akt to the plasma membrane has previously been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1688d8d323e4e7337b916f749f4f18dc
https://www.repository.cam.ac.uk/handle/1810/325592
https://www.repository.cam.ac.uk/handle/1810/325592
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 6944, p 6944 (2021)
International Journal of Molecular Sciences
International Journal of Molecular Sciences
The PI3K/mTOR signalling pathway plays a central role in the governing of cell growth, survival and metabolism. As such, it must integrate and decode information from both external and internal sources to guide efficient decision-making by the cell.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97bf0b960b7676c3c1de45051ec00033
https://www.mdpi.com/1422-0067/22/13/6944
https://www.mdpi.com/1422-0067/22/13/6944