Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Milad Botros"'
Autor:
Milad Botros, Carlotta Uttini, Gianpiero Sportelli, Luca Vignati, Fabrizio Zanetta, Giuseppe Giacalone, Matteo Caserio, Francesco Tarasconi
Publikováno v:
JURIX
Processing case-law contents for electronic publishing purposes is a time-consuming activity that encompasses several sub-tasks and usually involves adding annotations to the original text. On the other hand, recent trends in Artificial Intelligence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c33779325c122aa2851690b59eab8c08
https://doi.org/10.3233/faia200859
https://doi.org/10.3233/faia200859
Autor:
Nico Bettio, Chiara Cerruti, Giacomo Benedetto Silvestri, Milad Botros, Matteo Caserio, Diletta Milana, Francesco Tarasconi, Maria Stella Darena, Guido Siliprandi, Paolo Cerioli, Alessandra Fidanzi, Maria Luisa Gabrielli
Publikováno v:
Day 2 Tue, November 12, 2019.
In Oil and Gas, technical staff is daily involved in critical activities. Safety is therefore a key priority, even more so with frontier and continuously-updating technologies acting as a fundamental part of the transformation of the traditional indu
Autor:
Advait Arun Joshi, Nicole Gallo-Payet, Christian Sköld, A. M. S. Murugaiah, Yiqian Wan, Marie-Odile Guimond, Xiongyu Wu, Fred Nyberg, Anders Hallberg, Milad Botros, A. K. Mahalingam, Mathias Alterman, Charlotta Wallinder
Publikováno v:
Journal of Medicinal Chemistry. 55:2265-2278
A para substitution pattern of the phenyl ring is a characteristic feature of the first reported selective AT(2) receptor agonist M024/C21 (1) and all the nonpeptidic AT(2) receptor agonists described so far. Two series of compounds structurally rela
Autor:
Bianca Plouffe, Nicole Gallo-Payet, Xiongyu Wu, Anders Hallberg, Fred Nyberg, Milad Botros, Charlotta Wallinder, Mathias Alterman, Yiqian Wan, A. M. S. Murugaiah, A. K. Mahalingam
Publikováno v:
Bioorganic & Medicinal Chemistry. 18:4570-4590
Structural alterations to the benzylic position of the first drug-like selective angiotensin II AT(2) receptor agonist (1) have been performed, with the emphasis to reduce the CYP 450 inhibitory property of the initial structure. The imidazole moiety
Autor:
Milad Botros, Mathias Hallberg, Rebecca Fransson, Fred Nyberg, Anja Sandström, Gunnar Lindeberg, Christian Sköld
Publikováno v:
Journal of Medicinal Chemistry. 53:2383-2389
Substance P 1-7 (SP(1-7), H-Arg-Pro-Lys-Pro-Gln-Gln-Phe-OH) is the major bioactive metabolite of substance P. The interest in this heptapeptide originates from the observation that it modulates, and in certain cases opposes the effects of the parent
Autor:
Anna Carlsson, Torsten Gordh, Anja Sandström, Fred Nyberg, Qin Zhou, Mathias Hallberg, Rebecca Fransson, Milad Botros
Publikováno v:
Peptides. 30:2418-2422
We previously demonstrated that intracerebroventricular (i.c.v.) administration of the substance P (SP) aminoterminal fragment SP(1-7) attenuates the expression of morphine withdrawal in the male rat. In this study we have used a synthetic analogue o
Autor:
Fred Nyberg, Pierre Le Grevès, Gunnar Lindeberg, Milad Botros, Csaba Tömböly, Géza Tóth, Qin Zhou, Mathias Hallberg, Tobias Johansson
Publikováno v:
Peptides. 29:1820-1824
We have recently identified a specific binding site for the tachykinin peptide substance P (SP) fragment SP(1-7) in the rat spinal cord. This site appeared very specific for SP(1-7) as the binding affinity of this compound highly exceeded those of ot
Autor:
Ulrika Rosenström, Anders Hallberg, Nicole Gallo-Payet, Charlotta Wallinder, Milad Botros, Mathias Alterman, Fred Nyberg, Hélène Beaudry, Marie-Odile Guimond
Publikováno v:
Bioorganic & Medicinal Chemistry. 16:6841-6849
In the investigation of the structure-activity relationship of nonpeptide AT(2) receptor agonists, a series of substituted benzamide analogues of the selective nonpeptide AT(2) receptor agonist M024 have been synthesised. In a second series, the biph
Autor:
Mathias Alterman, Xiongyu Wu, Anders Karlén, Yiqian Wan, Nicole Gallo-Payet, A. K. Mahalingam, A. M. S. Murugaiah, Bianca Plouffe, Chalotta Wallinder, Mathias Hallberg, Milad Botros
Publikováno v:
Bioorganic & Medicinal Chemistry. 15:7166-7183
A versatile parallel synthetic method to obtain three series of non-cyclic analogues of the first drug-like selective angiotensin II AT(2) receptor agonist (1) has been developed. In analogy with the transformation of losartan to valsartan it was dem
Autor:
Milad Botros, Fred Nyberg, Hélène Beaudry, Nicole Gallo-Payet, Charlotta Wallinder, Anders Hallberg, Jennie Georgsson, Gunnar Lindeberg, Bianca Plouffe, Ulrika Rosenström, Anders Karlén
Publikováno v:
Bioorganic & Medicinal Chemistry. 14:5963-5972
Two pentapeptides, Ac-Tyr-Ile-His-Pro-Phe/Ile, were synthesized and shown to have angiotensin II AT2 receptor affinity and agonistic activity. Based on these peptides, a new series of 13 pseudopeptides was synthesized via introduction of five differe