Azacitidine Omega-3 Self-Assemblies: Synthesis, Characterization, and Potent Applications for Myelodysplastic Syndromes

Autor: Milad Baroud, Elise Lepeltier, Yolla El-Makhour, Nolwenn Lautram, Jerome Bejaud, Sylvain Thepot, Olivier Duval

Publikováno v: Pharmaceuticals, Vol 14, Iss 12, p 1317 (2021)

5-Azacitidine, a cytidine analogue used as a hypomethylating agent, is one of the main drugs for the treatment of myelodysplastic syndromes (MDSs) and acute myeloid leukemia (AML) in the elderly. However, after administration, it exhibits several lim

Externí odkaz: https://doaj.org/article/b21738572f654089beb9c95d5a35e179

The evolution of nucleosidic analogues: self-assembly of prodrugs into nanoparticles for cancer drug delivery

Autor: Milad Baroud, Olivier Duval, Sylvain Thepot, Yolla El-Makhour, Elise Lepeltier

Publikováno v: Nanoscale Advances
Nanoscale Advances, RSC, 2021, 3 (8), pp.2157-2179. ⟨10.1039/d0na01084g⟩
Nanoscale Advances, 2021, 3 (8), pp.2157-2179. ⟨10.1039/d0na01084g⟩

International audience; Nucleoside and nucleotide analogs are essential tools in our limited arsenal in the fight against cancer. However, these structures face severe drawbacks such as rapid plasma degradation or hydrophilicity, limiting their clini

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2118cd0e5df5bcfbdf79e618129ed9cd
https://hal.univ-angers.fr/hal-03448613/document