Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Mila M. Leuthold"'
Autor:
Bingqian Qu, Firat Nebioglu, Mila M. Leuthold, Yi Ni, Pascal Mutz, Jürgen Beneke, Holger Erfle, Florian W.R. Vondran, Ralf Bartenschlager, Stephan Urban
Publikováno v:
JHEP Reports, Vol 4, Iss 10, Pp 100551- (2022)
Background & Aims: HBV persistence is maintained by both an episomal covalently closed circular (ccc)DNA reservoir and genomic integration of HBV DNA fragments. While cccDNA transcription is regulated by Cullin4A-DDB1-HBx-mediated degradation of the
Externí odkaz:
https://doaj.org/article/1d481c9973124405ac084d481dbddc1d
Publikováno v:
mSphere, Vol 1, Iss 2 (2016)
ABSTRACT Human norovirus interacts with the polymorphic human histo-blood group antigens (HBGAs), and this interaction is thought to be important for infection. The genogroup II genotype 4 (GII.4) noroviruses are the dominant cluster, evolve every ot
Externí odkaz:
https://doaj.org/article/f378bb0c89dc4286b732365953f86e16
Autor:
Mila M. Leuthold, Turgay Kilic, Jessica M. Devant, Oscar Landeta, Francisco Parra, Kevin P. Dalton, Grant S. Hansman
Publikováno v:
J Virol
Rabbit hemorrhagic disease virus (RHDV) typically causes a fatal disease in rabbits. In Australia, RHDV was imported to control the feral rabbit population, while it poses a severe threat to native rabbits in other countries. RHDV variants are geneti
Publikováno v:
European journal of medicinal chemistry. 240
The RNA viruses SARS-CoV-2 and dengue pose a major threat to human health worldwide and their proteases (M
Publikováno v:
Slas Discovery
The COVID-19 pandemic, caused by the SARS-CoV-2 virus, has a huge impact on the world. Although several vaccines have recently reached the market, the development of specific antiviral drugs against SARS-CoV-2 is an important additional strategy in f
Publikováno v:
ACS Med Chem Lett
[Image: see text] Infections with flaviviruses such as dengue virus (DENV) are prevalent throughout tropical regions worldwide. Replication of these viruses depends on tubulin, a host cell factor that can be targeted to obtain broad-spectrum antivira
Autor:
Hiroaki Suga, Paul Varava, Toby Passioura, Christian D. Klein, Mithun C. Mahawaththa, Gottfried Otting, Christoph Nitsche, Mila M. Leuthold
Publikováno v:
ACS Medicinal Chemistry Letters. 10:168-174
[Image: see text] The Zika virus presents a major public health concern due to severe fetal neurological disorders associated with infections in pregnant women. In addition to vaccine development, the discovery of selective antiviral drugs is essenti
Publikováno v:
Journal of medicinal chemistry. 64(8)
The viral serine protease NS2B-NS3 is one of the promising targets for drug discovery against dengue virus and other flaviviruses. The molecular recognition preferences of the protease favor basic, positively charged moieties as substrates and inhibi
Autor:
Kevin P. Dalton, Francisco Parra, Mila M. Leuthold, Brigitte Fiege, Thomas Peters, Peter J. Meloncelli, Todd L. Lowary
Publikováno v:
Glycoconjugate Journal. 34:679-689
Attachment of human noroviruses to histo blood group antigens (HBGAs) is thought to be critical for the infection process. Therefore, we have determined binding epitopes of synthetic type 1 to 6 blood group A- and B-tetrasaccharides binding to GII.4
Autor:
Tonko Dražić, Branimir Bertoša, Mila M. Leuthold, Sara Kopf, Christian D. Klein, James Corridan
Publikováno v:
Journal of Medicinal Chemistry. 63:10530-10530