Patient phenotyping in clinical trials of chronic pain treatments: IMMPACT recommendations

Autor: Robert R. Edwards, Robert H. Dworkin, Dennis C. Turk, Martin S. Angst, Raymond Dionne, Roy Freeman, Per Hansson, Simon Haroutounian, Lars Arendt-Nielsen, Nadine Attal, Ralf Baron, Joanna Brell, Shay Bujanover, Laurie B. Burke, Daniel Carr, Amy S. Chappell, Penney Cowan, Mila Etropolski, Roger B. Fillingim, Jennifer S. Gewandter, Nathaniel P. Katz, Ernest A. Kopecky, John D. Markman, George Nomikos, Linda Porter, Bob A. Rappaport, Andrew S.C. Rice, Joseph M. Scavone, Joachim Scholz, Lee S. Simon, Shannon M. Smith, Jeffrey Tobias, Tina Tockarshewsky, Christine Veasley, Mark Versavel, Ajay D. Wasan, Warren Wen, David Yarnitsky

Publikováno v: PAIN Reports, Vol 6, Iss 1, p e899 (2021)

Abstract. There is tremendous interpatient variability in the response to analgesic therapy (even for efficacious treatments), which can be the source of great frustration in clinical practice. This has led to calls for “precision medicine” or pe

Externí odkaz: https://doaj.org/article/daf3aa186f274684ac1ec5b80f599fe5

First evaluation of tapentadol oral solution for the treatment of moderate to severe acute pain in children aged 6 to <18

Autor: Liping Zhang, Jutta Goldberg, Tao Sun, Julia C. Finkel, Rachel Ochs-Ross, Mila Etropolski, Ronald Rosenburg, Jay Ariyawansa, Peter Zannikos

Publikováno v: Journal of Pain Research. 12:1925-1936

Background This is the first clinical trial in the global pediatric clinical development program for the use of the analgesic tapentadol in children and adolescents. Patients and methods This multicenter, open-label clinical trial investigated pharma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f73d6c2875ee86a6c630a9ecd80c8f44
https://doi.org/10.2147/jpr.s197348

Patient phenotyping in clinical trials of chronic pain treatments: IMMPACT recommendations

Autor: Joachim Scholz, Roger B. Fillingim, David Yarnitsky, Tina Tockarshewsky, Shannon M. Smith, Dennis C. Turk, Shay Bujanover, Daniel B. Carr, Nadine Attal, Joanna M. Brell, Jeffrey Tobias, Nathaniel P. Katz, Penney Cowan, Joseph M. Scavone, Mila Etropolski, Martin S. Angst, Linda Porter, Jennifer S. Gewandter, Simon Haroutounian, Warren Wen, Robert H. Dworkin, Raymond A. Dionne, Mark Versavel, John D. Markman, Ajay D. Wasan, Christine Veasley, Lee S. Simon, Andrew S.C. Rice, Per Hansson, Robert R. Edwards, Ernest A. Kopecky, Lars Arendt-Nielsen, Amy S. Chappell, R. Baron, Bob A. Rappaport, George G. Nomikos, Laurie B. Burke, Roy Freeman

Publikováno v: PAIN Reports, Vol 6, Iss 1, p e899 (2021)
Edwards, R R, Dworkin, R H, Turk, D C, Angst, M S, Dionne, R, Freeman, R, Hansson, P, Haroutounian, S, Arendt-Nielsen, L, Attal, N, Baron, R, Brell, J, Bujanover, S, Burke, L B, Carr, D, Chappell, A S, Cowan, P, Etropolski, M, Fillingim, R B, Gewandter, J S, Katz, N P, Kopecky, E A, Markman, J D, Nomikos, G, Porter, L, Rappaport, B A, Rice, A S C, Scavone, J M, Scholz, J, Simon, L S, Smith, S M, Tobias, J, Tockarshewsky, T, Veasley, C, Versavel, M, Wasan, A D, Wen, W & Yarnitsky, D 2016, ' Patient phenotyping in clinical trials of chronic pain treatments : IMMPACT recommendations ', Pain, vol. 157, no. 9, pp. 1851-1871 . https://doi.org/10.1097/j.pain.0000000000000602
Edwards, R R, Dworkin, R H, Turk, D C, Angst, M S, Dionne, R, Freeman, R, Hansson, P, Haroutounian, S, Arendt-Nielsen, L, Attal, N, Baron, R, Brell, J, Bujanover, S, Burke, L B, Carr, D, Chappell, A S, Cowan, P, Etropolski, M, Fillingim, R B, Gewandter, J S, Katz, N P, Kopecky, E A, Markman, J D, Nomikos, G, Porter, L, Rappaport, B A, Rice, A S C, Scavone, J M, Scholz, J, Simon, L S, Smith, S M, Tobias, J, Tockarshewsky, T, Veasley, C, Versavel, M, Wasan, A D, Wen, W & Yarnitsky, D 2021, ' Patient phenotyping in clinical trials of chronic pain treatments : IMMPACT recommendations ', Pain Reports, vol. 6, no. 1, e896 . https://doi.org/10.1097/pr9.0000000000000896

There is tremendous interpatient variability in the response to analgesic therapy (even for efficacious treatments), which can be the source of great frustration in clinical practice. This has led to calls for “precision medicine” or personalized

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abd9ba5c6f5ac347f31b08f2ced337c8
http://journals.lww.com/painrpts/fulltext/10.1097/PR9.0000000000000896

A Pooled Analysis Evaluating the Efficacy and Tolerability of Tapentadol Extended Release for Chronic, Painful Diabetic Peripheral Neuropathy

Autor: C. Rauschkolb, Mila Etropolski, Sherwyn Schwartz, Juergen Haeussler, Bernd Lange, Douglas Y. Shapiro, Aaron I. Vinik, Kimberly Cooper, Ilse Van Hove

Publikováno v: Clinical Drug Investigation

Background and Objective Data from two similarly designed studies of tapentadol extended release (ER) for managing neuropathic pain associated with diabetic peripheral neuropathy (DPN; NCT00455520, NCT01041859) in adults were pooled for this analysis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa891e91ea6019fd17a8a52372f94d85
https://doi.org/10.1007/s40261-014-0249-3

Evaluation of Blood Pressure and Heart Rate in Patients with Hypertension Who Received Tapentadol Extended Release for Chronic Pain: A Post Hoc, Pooled Data Analysis

Autor: Mila Etropolski, David M. Biondi, Jim Xiang, Bruce L. Moskovitz

Publikováno v: Clinical Drug Investigation

Background and Objectives Hypertension is one of the most common co-existing conditions in patients with chronic pain, and the potential effects of an analgesic on heart rate and blood pressure are of particular concern for patients with hypertension

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a2f81bcdce0dc747976563584bbb0fb
http://europepmc.org/articles/PMC4102827