Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Mila, T."'
Autor:
Pacheco, B.Pereyra, Méndez Ribas, J.M., Milone, G., Fernández, I., Kvicala, R., Mila, T., Di Noto, A., Ortiz, O.Contreras, Pavlovsky, S.
Publikováno v:
In Gynecologic Oncology June 2001 81(3):391-397
Autor:
Levin, Jeremy I.1, Du, Mila T.1
Publikováno v:
Drug Design & Discovery. Dec2003, Vol. 18 Issue 4, p123-126. 4p.
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:3927-3931
A series of butynyloxyphenyl beta-sulfone piperidine hydroxamate TACE inhibitors was designed and synthesized. The resulting structure-activity relationship and MMP selectivity of the series were examined. Of the compounds investigated, 17s has excel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15941e8357434fac6d65d6cd6cc90815
https://doi.org/10.1016/j.bmcl.2006.05.026
https://doi.org/10.1016/j.bmcl.2006.05.026
Autor:
J.S. Skotnicki, James M. Chen, Jun Xu, Dauphine Barone, L.M. Laakso, J. Schmid, Weixin Xu, G. Jin, Terri Cummons, Jeremy I. Levin, Mila T. Du
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:1605-1609
A series of thiomorpholine sulfonamide hydroxamate TACE inhibitors, all bearing propargylic ether P1′ groups, was explored. In particular, compound 5h has excellent in vitro potency against isolated TACE enzyme and in cells, oral activity in a mode
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0df6b0972ea9394dbf7bdfc7bf784ea0
https://doi.org/10.1016/j.bmcl.2005.12.020
https://doi.org/10.1016/j.bmcl.2005.12.020
Autor:
Carvalheira, Gianna, Malinverni, Andrea M, Moysés-Oliveira, Mariana, Ueta, Renata, Cardili, Leonardo, Monteagudo, Patrícia, Mathez, Andreia L G, Verreschi, Ieda T, Maluf, Miguel A, Shida, Márcia E F, Leite, Mila T C, Mazzotti, Diego, Melaragno, Maria Isabel, Dias-da-Silva, Magnus R
Publikováno v:
Journal of the Endocrine Society; Nov2019, Vol. 3 Issue 11, p2107-2113, 7p
Autor:
Gloria Jean Macewan, Semiramis Ayral-Kaloustian, Terri Cummons, James M. Chen, Frances C. Nelson, Jun Xu, Dauphine Barone, Efren Guillermo Delos Santos, Mila T. Du, Jeremy I. Levin, Guixian Jin
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:4147-4151
A series of benzodiazepine MMP/TACE inhibitors bearing polar moieties has been synthesized in an effort to optimize inhibitory activity against LPS-stimulated TNF production in human monocytes and oral activity in a murine LPS model.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::794b0d59bead1b7ef67297cd05f85d49
https://doi.org/10.1016/j.bmcl.2004.06.031
https://doi.org/10.1016/j.bmcl.2004.06.031
Autor:
Mila T. Du, Jeremy I. Levin
Publikováno v:
Synthetic Communications. 32:1401-1406
Aryl fluorides react rapidly with 2-butyn-1-ol and potassium t-butoxide in DMSO under microwave irradiation to give propargylic ethers. These ethers isomerize in situ to the corresponding allenyl ethers, which hydrolyze on work-up to give phenols in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::76c5d3f540170731bdc4b0f4d5b546fa
https://doi.org/10.1081/scc-120003637
https://doi.org/10.1081/scc-120003637
Autor:
Jeremy I. Levin, Mila T. Du
Publikováno v:
ChemInform. 33
Aryl fluorides react rapidly with 2-butyn-1-ol and potassium t-butoxide in DMSO under microwave irradiation to give propargylic ethers. These ethers isomerize in situ to the corresponding allenyl ethers, which hydrolyze on work-up to give phenols in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::73a37d3404458d9ed79941b51d54d69b
https://doi.org/10.1002/chin.200237085
https://doi.org/10.1002/chin.200237085
Autor:
Jeremy I. Levin, L.M. Laakso, X. Du, James M. Chen, Jun Xu, J.S. Skotnicki, Vincent Sandanayaka, Yuhua Zhang, A.M. Venkatesan, Weixin Xu, Mila T. Du, A. Zask
Publikováno v:
Bioorganicmedicinal chemistry letters. 15(19)
The SAR of a series of potent sulfonamide hydroxamate TACE inhibitors bearing a butynyloxy P1' group was explored. In particular, compound 5k has excellent in vitro potency against TACE enzyme and in cells, and oral activity in an in vivo model of TN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02e438a70c5b9677809ea16f6324a6c7
https://pubmed.ncbi.nlm.nih.gov/16084720
https://pubmed.ncbi.nlm.nih.gov/16084720