Insulin in combination with pioglitazone prevents advanced cachexia in 256-Walker tumor-bearing rats: effect is greater than treatment alone and is associated with improved insulin sensitivity.

Autor: Miksza DR; Department of Physiological Sciences, State University of Londrina, Londrina, PR, 86051-990, Brazil., Biazi GR; Department of Physiological Sciences, State University of Londrina, Londrina, PR, 86051-990, Brazil., Frasson IG; Department of Physiological Sciences, State University of Londrina, Londrina, PR, 86051-990, Brazil., de Souza Galia WB; Department of Physiological Sciences, State University of Londrina, Londrina, PR, 86051-990, Brazil., Ferraz LS; Department of Physiological Sciences, State University of Londrina, Londrina, PR, 86051-990, Brazil., Diaz BF; Department of Physiological Sciences, State University of Londrina, Londrina, PR, 86051-990, Brazil., Kurauti MA; Department of Physiological Sciences, State University of Maringá, Maringá, PR, 87020-900, Brazil., Marmentini C; Department of Structural and Functional Biology, Campinas State University, Campinas, SP, 13083-862, Brazil., Mareze-Costa CE; Department of Physiological Sciences, State University of Maringá, Maringá, PR, 87020-900, Brazil., Peres SB; Department of Physiological Sciences, State University of Maringá, Maringá, PR, 87020-900, Brazil., Cassolla P; Department of Physiological Sciences, State University of Londrina, Londrina, PR, 86051-990, Brazil., Bertolini GL; Department of Physiological Sciences, State University of Londrina, Londrina, PR, 86051-990, Brazil., Bazotte RB; Department of Pharmacology and Therapeutics, State University of Maringá, Maringá, PR, 87020-900, Brazil., de Souza HM; Department of Physiological Sciences, State University of Londrina, Londrina, PR, 86051-990, Brazil. hmedri@uel.br.

Publikováno v: Pharmacological reports : PR [Pharmacol Rep] 2023 Dec; Vol. 75 (6), pp. 1571-1587. Date of Electronic Publication: 2023 Oct 07.

Interleukin 6 acutely increases gluconeogenesis and decreases the suppressive effect of insulin on cAMP-stimulated glycogenolysis in rat liver.

Autor: Biazi GR; Department of Physiological Sciences, State University of Londrina, Londrina, 86051-990, PR, Brazil., Uemura IGF; Department of Physiological Sciences, State University of Londrina, Londrina, 86051-990, PR, Brazil., Miksza DR; Department of Physiological Sciences, State University of Londrina, Londrina, 86051-990, PR, Brazil., Ferraz LS; Department of Physiological Sciences, State University of Londrina, Londrina, 86051-990, PR, Brazil., Diaz BF; Department of Physiological Sciences, State University of Londrina, Londrina, 86051-990, PR, Brazil., Bertolini GL; Department of Physiological Sciences, State University of Londrina, Londrina, 86051-990, PR, Brazil., de Souza HM; Department of Physiological Sciences, State University of Londrina, Londrina, 86051-990, PR, Brazil.

Publikováno v: Cell biochemistry and function [Cell Biochem Funct] 2023 Jul; Vol. 41 (5), pp. 609-618. Date of Electronic Publication: 2023 May 31.

Insulin secretion decline in Walker-256 tumor-bearing rats is early, follows the course of cachexia, and is not improved by lixisenatide.

Autor: Quintilhano DL; Department of Physiological Sciences, State University of Londrina, Londrina, PR, 86051-990, Brazil., Miksza DR; Department of Physiological Sciences, State University of Londrina, Londrina, PR, 86051-990, Brazil., de Souza Galia WB; Department of Physiological Sciences, State University of Londrina, Londrina, PR, 86051-990, Brazil., Ramalho MORC; Department of Physiological Sciences, State University of Londrina, Londrina, PR, 86051-990, Brazil., Lucena CF; Department of Physiology and Biophysics, University of São Paulo, Sao Paulo, PR, 05508-900, Brazil., Valle MMR; Department of Physiology and Biophysics, University of São Paulo, Sao Paulo, PR, 05508-900, Brazil., Graciano MFR; Department of Physiological Sciences, State University of Londrina, Londrina, PR, 86051-990, Brazil., de Souza HM; Department of Physiological Sciences, State University of Londrina, Londrina, PR, 86051-990, Brazil., Bertolini GL; Department of Physiological Sciences, State University of Londrina, Londrina, PR, 86051-990, Brazil. giselebertolini@uel.br.

Publikováno v: Naunyn-Schmiedeberg's archives of pharmacology [Naunyn Schmiedebergs Arch Pharmacol] 2021 Apr; Vol. 394 (4), pp. 697-705. Date of Electronic Publication: 2020 Oct 31.

Infusion of high concentration of lactate in perfused liver, simulating in vivo hyperlactatemia, prevents the reduction of gluconeogenesis in Walker-256 tumor-bearing rats.

Autor: Frasson-Uemura IG; Department of Physiological Sciences, State University of Londrina, Londrina, Paraná, Brazil., Biazi GR; Department of Physiological Sciences, State University of Londrina, Londrina, Paraná, Brazil., Miksza DR; Department of Physiological Sciences, State University of Londrina, Londrina, Paraná, Brazil., Moreira CCL; Department of Physiological Sciences, State University of Londrina, Londrina, Paraná, Brazil., Cassolla P; Department of Physiological Sciences, State University of Londrina, Londrina, Paraná, Brazil., Bertolini GL; Department of Physiological Sciences, State University of Londrina, Londrina, Paraná, Brazil., Bazotte RB; Department of Pharmacology and Therapeutics, State University of Maringá, Maringá, Paraná, Brazil., de Souza HM; Department of Physiological Sciences, State University of Londrina, Londrina, Paraná, Brazil.

Publikováno v: Journal of cellular biochemistry [J Cell Biochem] 2019 Jul; Vol. 120 (7), pp. 11068-11080. Date of Electronic Publication: 2019 Feb 05.

Tumor necrosis factor alpha abolished the suppressive effect of insulin on hepatic glucose production and glycogenolysis stimulated by cAMP.

Autor: da Rocha AF; Department of Physiological Sciences, State University of Londrina, Londrina, PR, Brazil., Liboni TF; Department of Physiological Sciences, State University of Londrina, Londrina, PR, Brazil., Kurauti MA; Department of Physiological Sciences, State University of Londrina, Londrina, PR, Brazil., de Souza CO; Department of Physiological Sciences, State University of Londrina, Londrina, PR, Brazil., Miksza DR; Department of Physiological Sciences, State University of Londrina, Londrina, PR, Brazil., Moreira CC; Department of Physiological Sciences, State University of Londrina, Londrina, PR, Brazil., Borba-Murad GR; Department of Physiological Sciences, State University of Londrina, Londrina, PR, Brazil., Bazotte RB; Department of Pharmacology and Therapeutics, State University of Maringá, Maringá, PR, Brazil., de Souza HM; Department of Physiological Sciences, State University of Londrina, Londrina, PR, Brazil. Electronic address: hmedri@uel.br.

Publikováno v: Pharmacological reports : PR [Pharmacol Rep] 2014 Jun; Vol. 66 (3), pp. 380-5. Date of Electronic Publication: 2014 Apr 03.