Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Mikolaj Slabicki"'
Autor:
Charles Zou, Hojong Yoon, Paul M.C. Park, J.J. Patten, Jesse Pellman, Jeannie Carreiro, Jonathan M. Tsai, Yen-Der Li, Shourya S. Roy Burman, Katherine A. Donovan, Jessica Gasser, Adam S. Sperling, Radosław P. Nowak, Eric S. Fischer, Robert A. Davey, Benjamin L. Ebert, Mikołaj Słabicki
Publikováno v:
iScience, Vol 26, Iss 5, Pp 106601- (2023)
Summary: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) hijacks multiple human proteins during infection and viral replication. To examine whether any viral proteins employ human E3 ubiquitin ligases, we evaluated the stability of SARS-
Externí odkaz:
https://doaj.org/article/cb16503b59c14a149316faaa454be17e
Autor:
Rob S. Sellar, Adam S. Sperling, Mikołaj Słabicki, Jessica A. Gasser, Marie E. McConkey, Katherine A. Donovan, Nada Mageed, Dylan N. Adams, Charles Zou, Peter G. Miller, Ravi K. Dutta, Steffen Boettcher, Amy E. Lin, Brittany Sandoval, Vanessa A. Quevedo Barrios, Veronica Kovalcik, Jonas Koeppel, Elizabeth K. Henderson, Emma C. Fink, Lu Yang, Anthony Chan, Sheela Pangeni Pokharel, Erik J. Bergstrom, Rajan Burt, Namrata D. Udeshi, Steven A. Carr, Eric S. Fischer, Chun-Wei Chen, Benjamin L. Ebert
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 16 (2022)
Targeted protein degradation is a rapidly advancing and expanding therapeutic approach. Drugs that degrade GSPT1 via the CRL4CRBN ubiquitin ligase are a new class of cancer therapy in active clinical development with evidence of activity against acut
Externí odkaz:
https://doaj.org/article/81fae13f3404407c97508eb3a6337c9d
Autor:
Mikołaj Słabicki, Mirko Theis, Dragomir B Krastev, Sergey Samsonov, Emeline Mundwiller, Magno Junqueira, Maciej Paszkowski-Rogacz, Joan Teyra, Anne-Kristin Heninger, Ina Poser, Fabienne Prieur, Jérémy Truchetto, Christian Confavreux, Cécilia Marelli, Alexandra Durr, Jean Philippe Camdessanche, Alexis Brice, Andrej Shevchenko, M Teresa Pisabarro, Giovanni Stevanin, Frank Buchholz
Publikováno v:
PLoS Biology, Vol 8, Iss 6, p e1000408 (2010)
DNA repair is essential to maintain genome integrity, and genes with roles in DNA repair are frequently mutated in a variety of human diseases. Repair via homologous recombination typically restores the original DNA sequence without introducing mutat
Externí odkaz:
https://doaj.org/article/f5f2a05ab4b94ace913261bc60a1e2dd
Autor:
Sebastian Wolf, Constanze Schneider, Roland Schmitz, Kwang Seok Lee, Mikolaj Slabicki, Hans Christian Reinhardt, Henning Urlaub, Craig J. Thomas, Anne C. Wilke, Hubert Serve, Fernando Kreuz, Joshua D. Rabinowitz, Dominique Jahn, Michele Ceribelli, Christian Brandts, Kimberly Stegmaier, Matthew G. Vander Heiden, Caroline A. Lewis, Thomas Oellerich, Kamil Bojarczuk, Thorsten Zenz, Daniel J. Hodson, Sara A Rieke, Yana Pikman, James Q Wang, Xincheng Xu, Michael Engelke, Hahn Kim, Hanibal Bohnenberger, Zana A. Coulibaly, Clemens A Schmitt, Federico Comoglio, James D. Phelan, Louis M. Staudt, Carmen Doebele, Sebastian Scheich, Björn Chapuy, Frank Schnuetgen, Gero Knittel, Frances A. Tosto, Philipp Stroebel, Alena Zindel, Björn Häupl, Philipp Stauder, Thanh Hung Dang
Publikováno v:
Blood
Burkitt lymphoma (BL) is an aggressive lymphoma type that is currently treated by intensive chemoimmunotherapy. Despite the favorable clinical outcome for most patients with BL, chemotherapy-related toxicity and disease relapse remain major clinical
Autor:
Mikolaj Slabicki, Katja Blumenstock, Per Hoffmann, Marius Jentzsch, Thomas S. Ebert, Maximilian Schmitz, Ofir Israeli, Markus M. Nöthen, Gero Wilbring, Manuel Döhla, Nina Ishorst, Julia Reinhardt, David Li, Nir Paran, Max L. Jacobs, Ines H. Kaltheuner, Eva C. Beins, Jonathan Strecker, Feng Zhang, Amir Ben-Shmuel, Ricarda Maria Schmithausen, Bärbel Lippke, David Feldman, Aliona Wöhler, Martin Exner, Esther Sib, Aviv Regev, Jana Liebing, Matthias Geyer, Brian Cleary, Jonathan L. Schmid-Burgk, Kerstin U. Ludwig, Ronja Hollstein, Wibke Rüdiger, Rhiannon K. Macrae, Shay Weiss, Jacob Borrajo, Lara M. Hochfeld, Michael Hölzel
Publikováno v:
Nature Biotechnology. 39:1556-1562
Frequent testing of large population groups combined with contact tracing and isolation measures will be crucial for containing Coronavirus Disease 2019 outbreaks. Here we present LAMP-Seq, a modified, highly scalable reverse transcription loop-media
UBR5 Is a Hect E3 Ubiquitin Ligase That Regulates Chromatin Bound Nuclear Hormone Receptor Stability
Autor:
Jonathan M Tsai, Jacob D Aguirre, Jared Brown, Vivian Focht, Yen-Der Li, Georg Kempf, Lukas Kater, Pius Galli, Simone Cavadini, Brittany E Sandoval, Charles Zou, Justine Rutter, Katherine Donovan, Quinlan Sievers, Paul Park, Jevon A. Cutler, Charlie Hatton, Elizabeth Ener, Micah T Sperling, Mikolaj Slabicki, Peter G. Miller, Roger Belizaire, Adam S. Sperling, Scott A. Armstrong, Eric S. Fischer, Nicolas Thomä, Benjamin L. Ebert
Publikováno v:
Blood. 140:2968-2969
Autor:
Shourya S. Roy Burman, Rohan Sharma, Moritz Hunkeler, Peter Miller, Benjamin L. Ebert, Stefan Fröhling, Andrew A Guirguis, Claudia Scholl, Lena Nitsch, Priya Chudasama, Radosław P. Nowak, Hojong Yoon, Katherine A. Donovan, Cristina Di Genua, Charles Zou, Adam S. Sperling, Jessica A. Gasser, Eric S. Fischer, Jonathan M. Tsai, Mikolaj Slabicki, Jonas Koeppel
Publikováno v:
Nature
Effective and sustained inhibition of non-enzymatic oncogenic driver proteins is a major pharmacological challenge. The clinical success of thalidomide analogues demonstrates the therapeutic efficacy of drug-induced degradation of transcription facto
Autor:
Dennis Gillingham, Jessica A. Gasser, Rob S. Sellar, Eric S. Fischer, Max Jan, Todd R. Golub, Manisha Manojkumar, Nicolas H. Thomä, Quinlan L. Sievers, Claudia Scholl, Stefan Fröhling, Li R. Wang, Zuzanna Kozicka, Katherine A. Donovan, Emma C. Fink, Adam S. Sperling, Yen-Der Li, Steven M. Corsello, Mikolaj Slabicki, Richard D. Bunker, Georg Petzold, Benjamin L. Ebert, Dakota Suchyta, Jonas Koeppel
Publikováno v:
Nature
Molecular glue compounds induce protein–protein interactions that, in the context of a ubiquitin ligase, lead to protein degradation. Unlike traditional enzyme inhibitors, these molecular glue degraders act substoichiometrically to catalyse the rap
Autor:
Mikolaj Slabicki, Mathijs A. Sanders, Minjung Lee, Olga Dakhova, Jaime M. Reyes, Lionel Van Maldergem, Christina Galonska, Dapeng Hao, Margaret A. Goodell, Xiaodong Cheng, Peter J. M. Valk, Venkatasubramaniam Sundaramurthy, Caroline Watson, Chun-Wei Chen, Yung-Hsin Huang, Yubin Zhou, Ayala Tovy, Yun Huang, Alexander Meissner, Lorenzo Brunetti, Wei Li, Brielle R. Crovetti, Benjamin L. Ebert, Katrina Tatton-Brown, Jamie R. Blundell
Publikováno v:
Cancer Discovery
Cancer Discovery, 12(1), 220-235. American Association for Cancer Research Inc.
Cancer Discovery, 12(1), 220-235. American Association for Cancer Research Inc.
Clonal hematopoiesis is a prevalent age-related condition associated with a greatly increased risk of hematologic disease; mutations in DNA methyltransferase 3A (DNMT3A) are the most common driver of this state. DNMT3A variants occur across the gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfa510b35a96d241e2486878bc3aac89
https://www.repository.cam.ac.uk/handle/1810/327471
https://www.repository.cam.ac.uk/handle/1810/327471
Autor:
Benjamin L. Ebert, David M. Evans, Mridul Agrawal, Veronica Shkolnik, Douglas P. Kiel, Christopher J. Gibson, Marie McConkey, Mesbah Uddin, Wesley J. Shin, Abhishek Niroula, Drew N. Cohen, James P. Pirruccello, Pradeep Natarajan, Mikolaj Slabicki, Mary L. Bouxsein, Alexander G. Bick, Waihay J. Wong, Gabriel K. Griffin, Daniel J. Brooks, Peter Geon Kim, Aswin Sekar, Julia F. Charles, J. Brent Richards, Amy E. Lin, Jonathan M. Tsai, Marc N. Wein, John P. Kemp, Siddhartha Jaiswal
Publikováno v:
The Journal of experimental medicine. 218(12)
Osteoporosis is caused by an imbalance of osteoclasts and osteoblasts, occurring in close proximity to hematopoietic cells in the bone marrow. Recurrent somatic mutations that lead to an expanded population of mutant blood cells is termed clonal hema