Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Miklos Csato"'
Autor:
Hans Senn, Laura Suter, Thomas Singer, Holger Fischer, Miklos Csato, Stefan Evers, Lucette Doessegger, Georg Schmitt, Elke-Astrid Atzpodien, Götz Schlotterbeck, Barbara Lenz
Publikováno v:
Therapeutic Advances in Drug Safety. 4:101-114
Background: Phospholipidosis (PLD) is a lysosomal storage disorder induced by a class of cationic amphiphilic drugs. However, drug-induced PLD is reversible. Evidence of PLD from animal studies with some compounds has led to discontinuation of develo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89ad8a7bbe867884f642a08bdd2d8bb8
https://doi.org/10.1177/2042098613479393
https://doi.org/10.1177/2042098613479393
Autor:
Miklos Csato, Barbara Lenz, Holger Fischer, Georg Schmitt, Thomas Singer, Lucette Doessegger, Elke-Astrid Atzpodien
Publikováno v:
Journal of medicinal chemistry. 55(1)
Phospholipidosis (PLD) is a lysosomal storage disorder induced by compounds, notably cationic amphiphilic drugs, which although reversible interferes with cellular phospholipids.The in silico method described utilizes the amphiphilic moment ΔΔG(AM)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0abcaa3e6ea14fa01c51317b195d383
https://pubmed.ncbi.nlm.nih.gov/22122484
https://pubmed.ncbi.nlm.nih.gov/22122484
Autor:
Bernd-Michael Loeffler, Aranka Müller, Jens-Uwe Peters, Miklos Csato, Markus Boehringer, Fabienne Ricklin, Daniel Hunziker, Holger Fischer, Silja Weber, Manfred Kansy, Angelina Wallier, Sonia Poli, Stéphane Kritter
Publikováno v:
Bioorganicmedicinal chemistry letters. 14(13)
A recently identified DPP-IV inhibitor (1) was found to induce phospholipidosis and to inhibit CYP3A4. A small series of less lipophilic and less amphiphilic analogues was synthesized in an effort to overcome these issues. One compound from this seri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3180fe93b65a1e511ad5e02a2eca20b6
https://pubmed.ncbi.nlm.nih.gov/15177477
https://pubmed.ncbi.nlm.nih.gov/15177477
Publikováno v:
Experimental dermatology. 4(1)
The depigmenting C57BL/6J-mivit/mivit) (mivit/mivit) mouse, a congenic mutant of the C57BL/6 strain, exhibits an isolated, single immune deficiency. It is unable to mount a normal immune/inflammatory response upon epicutaneous application of DNFB or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f23038686b065b76d9693a1dc9f4c33
https://pubmed.ncbi.nlm.nih.gov/7757328
https://pubmed.ncbi.nlm.nih.gov/7757328
Autor:
Holger Fischer, Elke-Astrid Atzpodien, Miklos Csato, Lucette Doessegger, Barbara Lenz, Georg Schmitt, Thomas Singer
Publikováno v:
Journal of Medicinal Chemistry; Jan2012, Vol. 55 Issue 1, p126-139, 14p