Zobrazeno 1 - 10
of 126
pro vyhledávání: '"Mikko Neuvonen"'
Autor:
Johanna I. Kiiski, Mikko Neuvonen, Mika Kurkela, Päivi Hirvensalo, Kreetta Hämäläinen, E. Katriina Tarkiainen, Johanna Sistonen, Mari Korhonen, Sofia Khan, Arto Orpana, Anne M. Filppula, Marko Lehtonen, Mikko Niemi
Publikováno v:
Human Genomics, Vol 18, Iss 1, Pp 1-16 (2024)
Abstract Background Individual assessment of CYP enzyme activities can be challenging. Recently, the potato alkaloid solanidine was suggested as a biomarker for CYP2D6 activity. Here, we aimed to characterize the sensitivity and specificity of solani
Externí odkaz:
https://doaj.org/article/18cc2cbe5e4e47a0accb684473def9e1
Autor:
Ville T. Männistö, Dorota Kaminska, Sylke Haal, Juho Asteljoki, Panu K. Luukkonen, Pirjo Käkelä, Federica Tavaglione, Michel van Weeghel, Mikko Neuvonen, Mikko Niemi, Stefano Romeo, Max Nieuwdorp, Jussi Pihlajamäki, Albert K. Groen
Publikováno v:
Gastro Hep Advances, Vol 3, Iss 5, Pp 594-601 (2024)
Background and Aims: Gallstone disease (GSD) associates with significant morbidity and mortality. Decreased secretion of bile acids has been suggested as a driving factor for GSD. Recently, we linked the protein phosphatase 1 regulatory subunit 3 bet
Externí odkaz:
https://doaj.org/article/7c50f06b369c41d088bab1ac22b8f9fd
Autor:
Kreetta Hämäläinen, Päivi Hirvensalo, Mikko Neuvonen, Aleksi Tornio, Janne T. Backman, Marko Lehtonen, Mikko Niemi
Publikováno v:
Clinical and Translational Science, Vol 17, Iss 3, Pp n/a-n/a (2024)
Abstract Our aim was to evaluate biomarkers for organic anion transporting polypeptide 1B1 (OATP1B1) function using a hypothesis‐free metabolomics approach. We analyzed fasting plasma samples from 356 healthy volunteers using non‐targeted metabol
Externí odkaz:
https://doaj.org/article/56c79fa71bd94ad2aa7e6b3fd2759921
Autor:
Lotta Ulander, Piia Simonen, Heli Tolppanen, Otto Hartman, Tuomas T. Rissanen, Kari K. Eklund, Marita Kalaoja, Mika Kurkela, Mikko Neuvonen, Mikko Niemi, Janne T. Backman, Helena Gylling, Juha Sinisalo
Publikováno v:
Atherosclerosis Plus, Vol 53, Iss , Pp 26-32 (2023)
Background and aims: To evaluate the effect of hydroxychloroquine (HCQ) on serum and lipoprotein lipids and serum biomarkers of cholesterol synthesis and absorption in myocardial infarction patients with a high-dose statin. Methods: Myocardial infarc
Externí odkaz:
https://doaj.org/article/e6fa16665d3e4070973c4a24f88db3bd
Autor:
Sirkku Kouki, Sanna J. Viitanen, Ninna Koho, Henna P. Laurila, Liisa Lilja‐Maula, Saila Holopainen, Mikko Neuvonen, Mikko Niemi, Aline Fastrès, Cécile Clercx, Minna M. Rajamäki
Publikováno v:
Journal of Veterinary Internal Medicine, Vol 37, Iss 1, Pp 268-276 (2023)
Abstract Background Salivary bile acids are used to diagnose extraesophageal reflux (EER) and to evaluate the risk of reflux aspiration that is associated with respiratory diseases in dogs. Objectives To study total bile acid (TBA) concentrations in
Externí odkaz:
https://doaj.org/article/7e536a3c944f4d889f1c7b0269d8196b
Autor:
Päivi Hirvensalo, Aleksi Tornio, Tuija Tapaninen, Maria Paile‐Hyvärinen, Mikko Neuvonen, Janne T. Backman, Mikko Niemi
Publikováno v:
Clinical and Translational Science, Vol 15, Iss 2, Pp 409-421 (2022)
Abstract The aim of this study was to search for associations of genetic variants with celiprolol pharmacokinetics in a large set of pharmacokinetic genes, and, more specifically, in a set of previously identified candidate genes ABCB1, SLCO1A2, and
Externí odkaz:
https://doaj.org/article/f35f6c69bf1d47e79c46e8a0f915094e
Autor:
Aleksi Nummela, Lauri Laaksonen, Annalotta Scheinin, Kaike Kaisti, Tero Vahlberg, Mikko Neuvonen, Katja Valli, Antti Revonsuo, Markus Perola, Mikko Niemi, Harry Scheinin, Timo Laitio
Publikováno v:
BJA Open, Vol 4, Iss , Pp 100114- (2022)
Background: This exploratory study aimed to investigate whether dexmedetomidine, propofol, sevoflurane, and S-ketamine affect oxylipins and bile acids, which are functionally diverse molecules with possible connections to cellular bioenergetics, immu
Externí odkaz:
https://doaj.org/article/d163803b1d2d4883a888baeba03238a1
Autor:
Ville Männistö, Dorota Kaminska, Pirjo Käkelä, Mikko Neuvonen, Mikko Niemi, Marcus Alvarez, Päivi Pajukanta, Stefano Romeo, Max Nieuwdorp, Albert.K. Groen, Jussi Pihlajamäki
Publikováno v:
Hepatology Communications, Vol 5, Iss 2, Pp 244-257 (2021)
The protein phosphatase 1 regulatory subunit 3B (PPP1R3B) gene is a target of farnesoid X receptor (FXR), which is a major regulator of bile acid metabolism. Both PPP1R3B and FXR have been suggested to take part in glycogen metabolism, which may expl
Externí odkaz:
https://doaj.org/article/d4c5adda74e94301a57e37d86ff80342
Autor:
Tuija Tapaninen, Aleksi M. Olkkola, Aleksi Tornio, Mikko Neuvonen, Erkki Elonen, Pertti J. Neuvonen, Mikko Niemi, Janne T. Backman
Publikováno v:
Clinical and Translational Science, Vol 13, Iss 2, Pp 345-351 (2020)
The oral bioavailability of ibrutinib is low and variable, mainly due to extensive first‐pass metabolism by cytochrome P450 (CYP) 3A4. The unpredictable exposure can compromise its safe and effective dosing. We examined the impact of itraconazole o
Externí odkaz:
https://doaj.org/article/701e1cf86da34400937cd534eb0f5ba8
Autor:
Christine C. Orozco, Mikko Neuvonen, Yi-An Bi, Matthew A. Cerny, Sumathy Mathialagan, Laurie Tylaska, Brian Rago, Chester Costales, Amanda King-Ahmad, Mikko Niemi, A. David Rodrigues
Publikováno v:
Molecular Pharmaceutics.