Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Mikko Kuoppamäki"'
Autor:
Sammeli Liikkanen, Janne Sinkkonen, Joni Suorsa, Valtteri Kaasinen, Eero Pekkonen, Mikko Kärppä, Filip Scheperjans, Teppo Huttunen, Toni Sarapohja, Ullamari Pesonen, Mikko Kuoppamäki, Tapani Keränen
Publikováno v:
PLOS Digital Health, Vol 2, Iss 4, p e0000225 (2023)
In the quantification of symptoms of Parkinson's disease (PD), healthcare professional assessments, patient reported outcomes (PRO), and medical device grade wearables are currently used. Recently, also commercially available smartphones and wearable
Externí odkaz:
https://doaj.org/article/012d6c5856004986a94efd8d4883e5a0
Autor:
Matti Kivikko, MD, PhD, Mikko Kuoppamäki, MD, PhD, Lauri Soinne, MD, PhD, Stig Sundberg, PhD, Pasi Pohjanjousi, MSc, Juha Ellmen, PhD, Risto O. Roine, MD, PhD
Publikováno v:
Current Therapeutic Research, Vol 77, Iss C, Pp 46-51 (2015)
Background: Intravenous levosimendan is indicated for acute heart failure. The compound has shown promising beneficial effects in ischemic stroke models. Objective: We evaluated the efficacy and safety of oral levosimendan in patients with a history
Externí odkaz:
https://doaj.org/article/c17078b80b814610aeb4c2bde7771e9a
Autor:
Johanna Tuunainen, Noora Sjöstedt, Mikko Vahteristo, Juha Ellmén, Mikko Kuoppamäki, Juha Rouru, Marjo Yliperttula
Publikováno v:
European Journal of Drug Metabolism and Pharmacokinetics. 48:23-34
The treatment of Parkinson's disease (PD) is still symptomatic since disease-modifying treatments for PD are not available. Oral levodopa is the gold standard for the treatment of PD motor symptoms. However, incomplete and fluctuating plasma exposure
Autor:
Michael Pulley, Mikko Kuoppamäki, Carolyn A Young, Jesus S. Mora Pardina, Kumaraswamy Sivakumar, Toni Sarapohja, Michael A. Elliott, Chafic Karam, Sandeep Rana, Orla Hardiman, Nathan P. Staff, Letizia Mazzini, Gabriele Mora, Thomas F. Meyer, Colleen O'Connell, Stéphanie Delstanche, Elham Bayat, Michael D. Weiss, Waqar Waheed, Nenad Mitrovic, Philippe Corcia, Marie-Hélène Soriani, Edward J. Kasarskis, Claudia Caponnetto, Dale J. Lange, Tuan Vu, Leo McCluskey, Berthold Schrank, Angela Genge, Matthew C. Kiernan, Valtteri V Aho, Manu Jokela, Philip Van Damme, Juan F. Vázquez Costa, Maurizio Inghilleri, Wolfgang Löscher, David Schultz, Tero Tapiola, Susanne Petri, Adriano Chiò, Gary L. Pattee, Julian Großkreutz, Ammar Al-Chalabi, Aziz Shaibani, Susan Mathers, Kevin J. Felice, Kimberly Goslin, James Caress, Matthias Boentert, Albert C. Ludolph, Aleksandar Radunovic, Robert D. Henderson, James Wymer, Todd Levine, Jakob Rath, Merrilee Needham, William Camu, Gaurav Guliani, Rune Johansson, Leonard H. van den Berg, Namita Goyal, Mark B. Bromberg, Bjorn Oskarsson, Annie Dionne, Eduardo Locatelli, Brent T. Harris, Suma Babu, Richard Bedlack, John Ravits, Jinsy A. Andrews, Philippe Couratier, Gabriele Siciliano, Hannu Laaksovirta, Kourosh Rezania, Lawrence Korngut, Eduardo Aguera Morales, Peter M Andersen, Eva Farrero Munoz, David Lacomis, Stephen N. Scelsa, Chris Garratt, Matthew Burford, Merit Cudkowicz, Nicholas J. Maragakis, Wendy Johnston, Martin M. Brown, Johannes Prudlo, Justin Y. Kwan, Dominic B. Fee, Senda Ajroud-Driss, Stephen A. Goutman, John Turnbull, Michael H. Rivner, Timothy M. Miller, Jan De Bleecker, Caroline Ingre, Luis Varona, Genevieve Matte, Daragh Heitzman, Robert Untucht, Lorne Zinman, Adam Quick, Jonathan S. Katz
Publikováno v:
The Lancet Neurology. 20:821-831
Summary Background There is an urgent unmet need for new therapies in amyotrophic lateral sclerosis. In a clinical study with healthy volunteers, levosimendan, a calcium sensitiser, was shown to improve neuromechanical efficiency and contractile func
Autor:
Mikko Vahteristo, Tuire Prami, Solomon Christopher, Mikko Kuoppamäki, Pasi Korhonen, Fabian Hoti, Juha Ellmen, Valtteri V Aho, Jari Haukka, Eero Pukkala
Publikováno v:
Movement Disorders. 30:724-728
Background The association between Parkinson's disease (PD) and prostate cancer, both common in elderly men, is disputable. In the STRIDE-PD study, prostate cancer developed in 9 patients (3.7%) receiving levodopa/carbidopa with entacapone, a catecho
Publikováno v:
Acta Neurologica Scandinavica. 130:239-247
Objectives To investigate efficacy and safety of entacapone across phase III studies in Parkinson's disease (PD) with wearing-off symptoms. Methods Retrospective, pooled analysis of four phase 3 randomized, double-blind, placebo-controlled studies wi
Autor:
Catherine A. Collins, David R. Williams, Tamas Revesz, Janice L. Holton, Constantinos Kallis, Mikko Kuoppamäki, Andrew J. Lees, Sean S. O'Sullivan, Laura Parkkinen
Publikováno v:
Neurology. 77:1420-1426
Background: Several in vitro studies have suggested levodopa (L-dopa) to be toxic to dopaminergic neurons and that it can modulate the aggregation process of alpha-synuclein. We investigated the relationship between cumulative lifetime dose of L-dopa
Publikováno v:
European Journal of Neurology. 16:1305-1311
Background: We analysed data from three clinical trials in Parkinson’s disease (PD) patients with wearing-off to determine whether early enhancement of levodopa therapy with entacapone can lead to better long-term outcomes than delayed entacapone t
Publikováno v:
Duodecim; laaketieteellinen aikakauskirja. 131(12)
The most common cause of monogenic hereditary Parkinson's disease is a mutation in the PARK2 gene. Early onset, slow progression, dystonia, and good response to levodopa are typical of the disease phenotype. Finnish PARK2 patients have not been descr
Autor:
Matti Kivikko, Lauri Soinne, Pasi Pohjanjousi, Risto O. Roine, Juha Ellmen, Mikko Kuoppamäki, Stig Sundberg
Publikováno v:
Current Therapeutic Research, Vol 77, Iss C, Pp 46-51 (2015)
Current Therapeutic Research, Clinical and Experimental
Current Therapeutic Research, Clinical and Experimental
Background Intravenous levosimendan is indicated for acute heart failure. The compound has shown promising beneficial effects in ischemic stroke models. Objective We evaluated the efficacy and safety of oral levosimendan in patients with a history of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d312a813ddc1f7c059263b4c078bd3d3
http://hdl.handle.net/10138/223778
http://hdl.handle.net/10138/223778