Zobrazeno 1 - 10
of 116
pro vyhledávání: '"Mikko J Frilander"'
Autor:
Maureen V. Akinyi, Mikko J. Frilander
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
Many eukaryotic species contain two separate molecular machineries for removing non-coding intron sequences from pre-mRNA molecules. The majority of introns (more than 99.5% in humans) are recognized and excised by the major spliceosome, which utiliz
Externí odkaz:
https://doaj.org/article/69a89b4c880e453a8a17fa7edae695b9
Autor:
Gabriel Á Martos‐Moreno, Lourdes Travieso‐Suárez, Jesús Pozo‐Román, María T Muñoz‐Calvo, Julie A Chowen, Mikko J Frilander, Luis A Pérez‐Jurado, Federico G Hawkins, Jesús Argente
Publikováno v:
EMBO Molecular Medicine, Vol 12, Iss 9, Pp n/a-n/a (2020)
Externí odkaz:
https://doaj.org/article/25c5950ce5c646468ff698eae73dd89d
Autor:
Jesús Argente, Raquel Flores, Armand Gutiérrez‐Arumí, Bhupendra Verma, Gabriel Á Martos‐Moreno, Ivon Cuscó, Ali Oghabian, Julie A Chowen, Mikko J Frilander, Luis A Pérez‐Jurado
Publikováno v:
EMBO Molecular Medicine, Vol 12, Iss 9, Pp n/a-n/a (2020)
Externí odkaz:
https://doaj.org/article/d2e7a76235fb4c859b656b689277ccd4
Publikováno v:
BMC Bioinformatics, Vol 19, Iss 1, Pp 1-10 (2018)
Abstract Background In-depth study of the intron retention levels of transcripts provide insights on the mechanisms regulating pre-mRNA splicing efficiency. Additionally, detailed analysis of retained introns can link these introns to post-transcript
Externí odkaz:
https://doaj.org/article/f3ba6fae92264acb9ec4abf6d763e15f
Publikováno v:
Cell Stress, Vol 2, Iss 3, Pp 40-54 (2018)
Pre-mRNA splicing is an essential step in eukaryotic gene expression. Mutations in cis-acting sequence elements within pre-mRNA molecules or trans-acting factors involved in pre-mRNA processing have both been linked to splicing dysfunction that give
Externí odkaz:
https://doaj.org/article/4e0031c6488649c0913a34757a132508
Publikováno v:
PeerJ, Vol 7, p e6140 (2019)
Wild plant populations may harbour a myriad of unknown viruses. As the majority of research efforts have targeted economically important plant species, the diversity and prevalence of viruses in the wild has remained largely unknown. However, the rec
Externí odkaz:
https://doaj.org/article/5c42125d108b46208e3d3da824ec8bc1
Micro-RNA (miRNA) genes represent one of the most constrained examples of genetic information found in metazoan genomes. All primary transcripts generated from these elements fold into a short RNA stem-loop structure that is further processed to a *2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::575aab464e3ce1fef9827e46b6d65a9e
https://doi.org/10.1101/2023.04.19.537475
https://doi.org/10.1101/2023.04.19.537475
Autor:
Gabriel Á Martos‐Moreno, Lourdes Travieso‐Suárez, Jesús Pozo‐Román, María T Muñoz‐Calvo, Julie A Chowen, Mikko J Frilander, Luis A Pérez‐Jurado, Federico G Hawkins, Jesús Argente
Publikováno v:
EMBO Molecular Medicine, Vol 10, Iss 7, Pp n/a-n/a (2018)
Externí odkaz:
https://doaj.org/article/3f7e933f66b94e9b9afff55bef9f5059
Autor:
Jens Verbeeren, Bhupendra Verma, Elina H Niemelä, Karen Yap, Eugene V Makeyev, Mikko J Frilander
Publikováno v:
PLoS Genetics, Vol 13, Iss 5, p e1006824 (2017)
Cellular homeostasis of the minor spliceosome is regulated by a negative feed-back loop that targets U11-48K and U11/U12-65K mRNAs encoding essential components of the U12-type intron-specific U11/U12 di-snRNP. This involves interaction of the U11 sn
Externí odkaz:
https://doaj.org/article/db1e852f794c46a88539e4da8f25ae15
Autor:
Jesús Argente, Raquel Flores, Armand Gutiérrez‐Arumí, Bhupendra Verma, Gabriel Á Martos‐Moreno, Ivon Cuscó, Ali Oghabian, Julie A Chowen, Mikko J Frilander, Luis A Pérez‐Jurado
Publikováno v:
EMBO Molecular Medicine, Vol 6, Iss 3, Pp 299-306 (2014)
Abstract The molecular basis of a significant number of cases of isolated growth hormone deficiency remains unknown. We describe three sisters affected with severe isolated growth hormone deficiency and pituitary hypoplasia caused by biallelic mutati
Externí odkaz:
https://doaj.org/article/0c62d11ee4ff4c95b77c0b3ae95baeb8