Zobrazeno 1 - 10
of 212
pro vyhledávání: '"Mikko J, Lammi"'
Autor:
Mikko J. Lammi, Chengjuan Qu
Publikováno v:
Bioengineering, Vol 11, Iss 3, p 211 (2024)
Cartilage defects and osteoarthritis are health problems which are major burdens on health care systems globally, especially in aging populations. Cartilage is a vulnerable tissue, which generally faces a progressive degenerative process when injured
Externí odkaz:
https://doaj.org/article/9add750b9bc041628e709b3595d0803b
Publikováno v:
Frontiers in Genetics, Vol 14 (2023)
Objective: This study aimed to investigate the roles of accessible chromatin in understanding the different pathogeneses between Kashin–Beck disease (KBD) and primary osteoarthritis (OA).Methods: Articular cartilages of KBD and OA patients were col
Externí odkaz:
https://doaj.org/article/7f9988d44d034c718733e71a054708e7
Publikováno v:
Frontiers in Genetics, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/02cd29aced31478f8bc00e44f7ad2510
Autor:
Yujie Ning, Minhan Hu, Yi Gong, Ruitian Huang, Ke Xu, Sijie Chen, Feiyu Zhang, Yanli Liu, Feihong Chen, Yanhai Chang, Guanghui Zhao, Cheng Li, Rong Zhou, Mikko J. Lammi, Xiong Guo, Xi Wang
Publikováno v:
Arthritis Research & Therapy, Vol 24, Iss 1, Pp 1-13 (2022)
Abstract Background Osteoarthritis (OA) and Kashin-Beck disease (KBD) both are two severe osteochondral disorders. In this study, we aimed to compare the gut microbiota structure between OA and KBD patients. Methods Fecal samples collected from OA an
Externí odkaz:
https://doaj.org/article/972bddd5c63f4f03bda25dc3ec73d059
Autor:
Xi Wang, Yujie Ning, Cheng Li, Yi Gong, Ruitian Huang, Minhan Hu, Blandine Poulet, Ke Xu, Guanghui Zhao, Rong Zhou, Mikko J. Lammi, Xiong Guo
Publikováno v:
Cell Death and Disease, Vol 12, Iss 11, Pp 1-12 (2021)
Abstract Kashin-Beck disease (KBD) is a severe osteochondral disorder that may be driven by the interaction between genetic and environmental factors. We aimed to improve our understanding of the gut microbiota structure in KBD patients of different
Externí odkaz:
https://doaj.org/article/ae8bc58788294b7c8d1fbe9abf5dd05f
Autor:
Xi Wang, Yujie Ning, Pan Zhang, Blandine Poulet, Ruitian Huang, Yi Gong, Minhan Hu, Cheng Li, Rong Zhou, Mikko J. Lammi, Xiong Guo
Publikováno v:
Cell Death and Disease, Vol 12, Iss 6, Pp 1-15 (2021)
Abstract Chondrocytes are the key target cells of the cartilage degeneration that occurs in Kashin–Beck disease (KBD) and osteoarthritis (OA). However, the heterogeneity of articular cartilage cell types present in KBD and OA patients and healthy c
Externí odkaz:
https://doaj.org/article/2db8de405c91438dbe3bbc30dc84db0f
Autor:
Yanan Zhang, Huan Liu, Xialu Lin, Feng’e Zhang, Peilin Meng, Sijia Tan, Mikko J. Lammi, Xiong Guo
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
Kashin–Beck disease (KBD) mainly damages growth plate of adolescents and is susceptible to both gene and gene–environmental risk factors. HT-2 toxin, which is a primary metabolite of T-2 toxin, was regarded as one of the environmental risk factor
Externí odkaz:
https://doaj.org/article/d839e7f430f643beafb8a095f2d58ff6
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract Articular chondrocytes are slowly dividing cells that tend to lose their cell type-specific phenotype and ability to produce structurally and functionally correct cartilage tissue when cultured. Thus, culture conditions, which enhance the ma
Externí odkaz:
https://doaj.org/article/293a096374814e7e8467ae0f6f0fd064
Autor:
Yang Lei, Zhao Guanghui, Wang Xi, Wang Yingting, Lin Xialu, Yu Fangfang, Mary B. Goldring, Guo Xiong, Mikko J. Lammi
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Abstract The relationship between T-2 toxin and deoxynivalenol (DON) and the risk of Kashin-Beck disease is still controversial since it is poorly known about their selectivity in cartilage damage. We aimed to compare the cytotoxicity of T-2 toxin an
Externí odkaz:
https://doaj.org/article/0aff6a293be84ac8831c3ff209026894
Autor:
Yizhen Lyu, Huan Deng, Chengjuan Qu, Lichun Qiao, Xuan Liu, Xiang Xiao, Jiaxin Liu, Ziwei Guo, Yan Zhao, Jing Han, Mikko J. Lammi
Publikováno v:
International Journal of Biological Macromolecules. 210:128-138
The aim of this study was to identify crucial proteins and N-glycosylated sites in the pathological mechanism of Kashin-Beck disease (KBD) compared with osteoarthritis (OA). Nine KBD knee subjects and nine OA knee subjects were selected for the study
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44cd573a7e724f661bf2c9b55224f110
https://doi.org/10.1016/j.ijbiomac.2022.05.014
https://doi.org/10.1016/j.ijbiomac.2022.05.014