Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Mikko Huhtala"'
Autor:
Mikko Huhtala
Publikováno v:
U.Porto Journal of Engineering, Vol 9, Iss 1, Pp 160-176 (2023)
Technical progress is rapid in aviation and automotive engineering. Even if these branches are different in many ways, they also have similarities, especially in the technical and service sectors. Quite a few technological innovations were first used
Externí odkaz:
https://doaj.org/article/43e9a43c9dab41448102f1d31b4ce9d3
Publikováno v:
Pharmaceutics, Vol 15, Iss 5, p 1473 (2023)
The development and production of innovative protein-based therapeutics is a complex and challenging avenue. External conditions such as buffers, solvents, pH, salts, polymers, surfactants, and nanoparticles may affect the stability and integrity of
Externí odkaz:
https://doaj.org/article/e5b78f2ea65b478d8c85811a1243ab13
Autor:
Sanna Vuoristo, Shruti Bhagat, Christel Hydén-Granskog, Masahito Yoshihara, Lisa Gawriyski, Eeva-Mari Jouhilahti, Vipin Ranga, Mahlet Tamirat, Mikko Huhtala, Ida Kirjanov, Sonja Nykänen, Kaarel Krjutškov, Anastassius Damdimopoulos, Jere Weltner, Kosuke Hashimoto, Gaëlle Recher, Sini Ezer, Priit Paluoja, Pauliina Paloviita, Yujiro Takegami, Ai Kanemaru, Karolina Lundin, Tomi T. Airenne, Timo Otonkoski, Juha S. Tapanainen, Hideya Kawaji, Yasuhiro Murakawa, Thomas R. Bürglin, Markku Varjosalo, Mark S. Johnson, Timo Tuuri, Shintaro Katayama, Juha Kere
Publikováno v:
iScience, Vol 25, Iss 4, Pp 104137- (2022)
Summary: Double homeobox 4 (DUX4) is expressed at the early pre-implantation stage in human embryos. Here we show that induced human DUX4 expression substantially alters the chromatin accessibility of non-coding DNA and activates thousands of newly i
Externí odkaz:
https://doaj.org/article/e20d78e8cdab451083fb4b3f94c08b7f
Autor:
Peter Bruckner, Mikko Huhtala, Uwe Hansen, Johannes A. Eble, Christian Gil Girol, Jarmo Käpylä, Jyrki Heino, Birgit Leitinger, Rita Dreier, Christian Woltersdorf, Stephan Niland, Melanie Bonk
Publikováno v:
Matrix Biology. 63:91-105
Interactions of cells with supramolecular aggregates of the extracellular matrix (ECM) are mediated, in part, by cell surface receptors of the integrin family. These are important molecular components of cell surface-suprastructures regulating cellul
Autor:
Timo Hyypiä, Varpu Marjomäki, Daniel J. White, Jarmo Käpylä, Mikko Huhtala, Jyrki Heino, Kalle Sipilä, Liisa Nissinen, Johanna Jokinen, J. Santeri Puranen, Mark S. Johnson, Pasi Kankaanpää, Maria Salmela
Publikováno v:
The EMBO Journal. 29:196-208
Conformational activation increases the affinity of integrins to their ligands. On ligand binding, further changes in integrin conformation elicit cellular signalling. Unlike any of the natural ligands of alpha2beta1 integrin, human echovirus 1 (EV1)
Autor:
Olli T. Pentikäinen, Mikko Huhtala, Dag Björklund, Susanna Repo, Jukka V. Lehtonen, Dan-Johan Still, Ville-Veikko Rantanen, Tommi Nyrönen, Antti Jussila, Mats Gyllenberg, Mark S. Johnson, Zuhair Iftikhar, Jan Ekholm, Jussi Jaakkola, Tiina A. Salminen
Publikováno v:
Journal of Computer-Aided Molecular Design. 18:401-419
BODIL is a molecular modeling environment geared to help the user to quickly identify key features of proteins critical to molecular recognition, especially (1) in drug discovery applications, and (2) to understand the structural basis for function.
Publikováno v:
The international journal of biochemistrycell biology. 41(2)
Collagens are large, triple-helical proteins that form fibrils and network-like structures in the extracellular matrix. The collagens may have participated in the evolution of the metazoans from their very earliest origins. Cell adhesion receptors, s
Publikováno v:
Structure-Based Study of Viral Replication: (With CD-ROM)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::00dfcc2b3afe2cc56aa810909aaceebc
https://doi.org/10.1142/9789812790859_0003
https://doi.org/10.1142/9789812790859_0003
Autor:
Jyrki Heino, Mira Tulla, Juha Jäälinoja, Richard W. Farndale, Mark S. Johnson, Leena Ala-Kokko, Mikko Huhtala, Jarmo Käpylä
Publikováno v:
FEBS letters. 581(13)
AlphaI domain integrins have been found in the ascidian Ciona intestinalis. We produced Ciona alpha1I domain as a recombinant protein. It did not recognize fibril-forming collagens or bind to GFOGER or other similar motifs in triple-helical peptides.
Publikováno v:
Matrix biology : journal of the International Society for Matrix Biology. 24(2)
Integrins are a family of alphabeta heterodimeric receptors essential to cell adhesion in all metazoans. In humans, the family consists of 18 alpha and 8 beta subunits that combine to form 24 dimers. Here, we present phylogenetic reconstructions for