Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Mikko Helenius"'
Autor:
Arlene L. Oei, Preethi Korangath, Kathleen Mulka, Mikko Helenius, Jonathan B. Coulter, Jacqueline Stewart, Esteban Velarde, Johannes Crezee, Brian Simons, Lukas J. A. Stalpers, H. Petra Kok, Kathleen Gabrielson, Nicolaas A. P. Franken, Robert Ivkov
Publikováno v:
International Journal of Hyperthermia, Vol 36, Iss 0, Pp 47-63 (2019)
Purpose: Enhancing immune responses in triple negative breast cancers (TNBCs) remains a challenge. Our study aimed to determine whether magnetic iron oxide nanoparticle (MION) hyperthermia (HT) can enhance abscopal effects with radiotherapy (RT) and
Externí odkaz:
https://doaj.org/article/373ac4be0e8649e7bbb04b8ecf130b94
Autor:
Karolina Losenkova, Mariachiara Zuccarini, Mikko Helenius, Evgenia V. Gerasimovskaya, Guillaume Jacquemet, Gennady G. Yegutkin, Camilla Tallgren, Sirpa Jalkanen
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1864:1804-1815
Intravascular ATP and adenosine have emerged as important regulators of endothelial barrier function, vascular remodeling and neovascularization at various pathological states, including hypoxia, inflammation and oxidative stress. By using human umbi
Autor:
Mikko Helenius, H. Petra Kok, Kathleen L. Gabrielson, Johannes Crezee, Arlene L. Oei, Preethi Korangath, Jacqueline Stewart, Robert Ivkov, Nicolaas A. P. Franken, Lukas J.A. Stalpers, Jonathan Coulter, Kathleen R. Mulka, Esteban Velarde, Brian W. Simons
Publikováno v:
International Journal of Hyperthermia, Vol 36, Iss 0, Pp 47-63 (2019)
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group
International journal of hyperthermia, 36, 47-63. Informa Healthcare
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group
International journal of hyperthermia, 36, 47-63. Informa Healthcare
Purpose: Enhancing immune responses in triple negative breast cancers (TNBCs) remains a challenge. Our study aimed to determine whether magnetic iron oxide nanoparticle (MION) hyperthermia (HT) can enhance abscopal effects with radiotherapy (RT) and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bd8196de31114c83a4619c237bdb7bd
Publikováno v:
International journal of cancer. 144(7)
Autor:
Joonas Aho, Lingli Wang, Pekka Taimen, Sanna Vattulainen, Tero-Pekka Alastalo, Juha Koskenvuo, Vinicio A. de Jesus Perez, Anne Komulainen, Mikko Helenius, Mark Orcholski
Publikováno v:
AJP - Lung Cellular and Molecular Physiology. 308(10):L1046-L1057
Endothelial cell (EC) dysfunction plays a role in the pathobiology of occlusive vasculopathy in pulmonary arterial hypertension (PAH). Purinergic signaling pathways, which consist of extracellular nucleotide and nucleoside-mediated cell signaling thr
Autor:
Tero-Pekka Alastalo, Vinicio A. de Jesus Perez, Samuel Myllykangas, Mark Orcholski, Molong Li, Pekka Taimen, Ke Yuan, Joonas Aho, Sanna Vattulainen, Mikko Helenius, Vanessa Rojas, Juha Koskenvuo
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 50:1118-1128
Occlusive vasculopathy with intimal hyperplasia and plexogenic arteriopathy are severe histopathological changes characteristic of pulmonary arterial hypertension (PAH). Although a phenotypic switch in pulmonary endothelial cells (ECs) has been sugge
Autor:
Rasmus Kentala, Pekka Taimen, Juha Koskenvuo, Timo Savunen, Antti Saraste, Christoffer Stark, Mikko Helenius, Tero-Pekka Alastalo
Thymosin beta 4 is a promising agent in preclinical regenerative and cardioprotection research. After myocardial injury it improves cell survival, reduces inflammation and activates epicardial progenitor cells. The peptide is also involved in cardiac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc3484f14b20853b4e368b2a132fcead
http://hdl.handle.net/10138/231417
http://hdl.handle.net/10138/231417
Cell damage can lead to rapid release of ATP to extracellular space resulting in dramatic change in local ATP concentration. Evolutionary, this has been considered as a danger signal leading to adaptive responses in adjacent cells. Our aim was to dem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5a944f60331fd94b231e5267eed00c3
http://hdl.handle.net/10138/228253
http://hdl.handle.net/10138/228253
Autor:
Daria Bulanova, John W.M. Martens, Kristiina Väänänen, Evgeny N. Imyanitov, Yuexi Gu, Anna P. Sokolenko, Sergey G. Kuznetsov, Jani Saarela, Mikko Helenius
Publikováno v:
Scientific Reports
Scientific Reports, 6:28217. Nature Publishing Group
Scientific Reports, 6:28217. Nature Publishing Group
Germ-line or somatic inactivation of BRCA1 is a defining feature for a portion of human breast cancers. Here we evaluated the anti-proliferative activity of 198 FDA-approved and experimental drugs against four BRCA1-mutant (HCC1937, MDA-MB-436, SUM13
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4509954217069fbc0234e760e4c23e5
http://hdl.handle.net/10138/164700
http://hdl.handle.net/10138/164700
Autor:
Saku Ruohonen, Juhani Knuuti, Antti Saraste, Pekka Taimen, Christoffer Stark, Markus Malmberg, Juho Jalkanen, Tommi Vähäsilta, Matti Savo, Tero-Pekka Alastalo, Timo Savunen, Rasmus Kentala, Mikko Helenius, Juha Koskenvuo, Ville-Veikko Hynninen, Miikka Tarkia
Publikováno v:
Frontiers in Pharmacology
The use of cardiopulmonary bypass (CPB) and aortic cross-clamping causes myocardial ischemia-reperfusion injury (I-RI) and can lead to reduced postoperative cardiac function. We investigated whether this injury could be attenuated by thymosin beta 4