Zobrazeno 1 - 10 of 14 pro vyhledávání: '"Mikko Helenius"'
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Akademický článek
Enhancing the abscopal effect of radiation and immune checkpoint inhibitor therapies with magnetic nanoparticle hyperthermia in a model of metastatic breast cancer
Autor: Arlene L. Oei, Preethi Korangath, Kathleen Mulka, Mikko Helenius, Jonathan B. Coulter, Jacqueline Stewart, Esteban Velarde, Johannes Crezee, Brian Simons, Lukas J. A. Stalpers, H. Petra Kok, Kathleen Gabrielson, Nicolaas A. P. Franken, Robert Ivkov
Publikováno v: International Journal of Hyperthermia, Vol 36, Iss 0, Pp 47-63 (2019)
Purpose: Enhancing immune responses in triple negative breast cancers (TNBCs) remains a challenge. Our study aimed to determine whether magnetic iron oxide nanoparticle (MION) hyperthermia (HT) can enhance abscopal effects with radiotherapy (RT) and
Externí odkaz: https://doaj.org/article/373ac4be0e8649e7bbb04b8ecf130b94
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2
Endothelial cells cope with hypoxia-induced depletion of ATP via activation of cellular purine turnover and phosphotransfer networks
Autor: Karolina Losenkova, Mariachiara Zuccarini, Mikko Helenius, Evgenia V. Gerasimovskaya, Guillaume Jacquemet, Gennady G. Yegutkin, Camilla Tallgren, Sirpa Jalkanen
Publikováno v: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1864:1804-1815
Intravascular ATP and adenosine have emerged as important regulators of endothelial barrier function, vascular remodeling and neovascularization at various pathological states, including hypoxia, inflammation and oxidative stress. By using human umbi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f344bd0479b6f60cc258de32005fb99
https://doi.org/10.1016/j.bbadis.2018.03.001
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3
Enhancing the abscopal effect of radiation and immune checkpoint inhibitor therapies with magnetic nanoparticle hyperthermia in a model of metastatic breast cancer
Autor: Mikko Helenius, H. Petra Kok, Kathleen L. Gabrielson, Johannes Crezee, Arlene L. Oei, Preethi Korangath, Jacqueline Stewart, Robert Ivkov, Nicolaas A. P. Franken, Lukas J.A. Stalpers, Jonathan Coulter, Kathleen R. Mulka, Esteban Velarde, Brian W. Simons
Publikováno v: International Journal of Hyperthermia, Vol 36, Iss 0, Pp 47-63 (2019)
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group
International journal of hyperthermia, 36, 47-63. Informa Healthcare
Purpose: Enhancing immune responses in triple negative breast cancers (TNBCs) remains a challenge. Our study aimed to determine whether magnetic iron oxide nanoparticle (MION) hyperthermia (HT) can enhance abscopal effects with radiotherapy (RT) and
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bd8196de31114c83a4619c237bdb7bd
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5
Suppression of endothelial CD39/ENTPD1 is associated with pulmonary vascular remodeling in pulmonary arterial hypertension
Autor: Joonas Aho, Lingli Wang, Pekka Taimen, Sanna Vattulainen, Tero-Pekka Alastalo, Juha Koskenvuo, Vinicio A. de Jesus Perez, Anne Komulainen, Mikko Helenius, Mark Orcholski
Publikováno v: AJP - Lung Cellular and Molecular Physiology. 308(10):L1046-L1057
Endothelial cell (EC) dysfunction plays a role in the pathobiology of occlusive vasculopathy in pulmonary arterial hypertension (PAH). Purinergic signaling pathways, which consist of extracellular nucleotide and nucleoside-mediated cell signaling thr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05a9190932b68ae14bd36e8bb4a2ceba
https://doi.org/10.1152/ajplung.00340.2014
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6
Loss of Bone Morphogenetic Protein Receptor 2 Is Associated with Abnormal DNA Repair in Pulmonary Arterial Hypertension
Autor: Tero-Pekka Alastalo, Vinicio A. de Jesus Perez, Samuel Myllykangas, Mark Orcholski, Molong Li, Pekka Taimen, Ke Yuan, Joonas Aho, Sanna Vattulainen, Mikko Helenius, Vanessa Rojas, Juha Koskenvuo
Publikováno v: American Journal of Respiratory Cell and Molecular Biology. 50:1118-1128
Occlusive vasculopathy with intimal hyperplasia and plexogenic arteriopathy are severe histopathological changes characteristic of pulmonary arterial hypertension (PAH). Although a phenotypic switch in pulmonary endothelial cells (ECs) has been sugge
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20262812cd4e94a03e64641ae6106a85
https://doi.org/10.1165/rcmb.2013-0349oc
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7
Thymosin beta 4 treatment improves left ventricular function after myocardial infarction and is related to Up-regulation of chitinase 3-like-1 in mice
Autor: Rasmus Kentala, Pekka Taimen, Juha Koskenvuo, Timo Savunen, Antti Saraste, Christoffer Stark, Mikko Helenius, Tero-Pekka Alastalo
Thymosin beta 4 is a promising agent in preclinical regenerative and cardioprotection research. After myocardial injury it improves cell survival, reduces inflammation and activates epicardial progenitor cells. The peptide is also involved in cardiac
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc3484f14b20853b4e368b2a132fcead
http://hdl.handle.net/10138/231417
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8
Extracellular ATP protects endothelial cells against DNA damage
Autor: Joonas Aho, Sanna Vattulainen-Collanus, Juha Koskenvuo, Tero-Pekka Alastalo, Mikko Helenius
Cell damage can lead to rapid release of ATP to extracellular space resulting in dramatic change in local ATP concentration. Evolutionary, this has been considered as a danger signal leading to adaptive responses in adjacent cells. Our aim was to dem
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5a944f60331fd94b231e5267eed00c3
http://hdl.handle.net/10138/228253
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9
BRCA1-deficient breast cancer cell lines are resistant to MEK inhibitors and show distinct sensitivities to 6-thioguanine
Autor: Daria Bulanova, John W.M. Martens, Kristiina Väänänen, Evgeny N. Imyanitov, Yuexi Gu, Anna P. Sokolenko, Sergey G. Kuznetsov, Jani Saarela, Mikko Helenius
Publikováno v: Scientific Reports
Scientific Reports, 6:28217. Nature Publishing Group
Germ-line or somatic inactivation of BRCA1 is a defining feature for a portion of human breast cancers. Here we evaluated the anti-proliferative activity of 198 FDA-approved and experimental drugs against four BRCA1-mutant (HCC1937, MDA-MB-436, SUM13
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4509954217069fbc0234e760e4c23e5
http://hdl.handle.net/10138/164700
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10
Systemic Dosing of Thymosin Beta 4 before and after Ischemia Does Not Attenuate Global Myocardial Ischemia-Reperfusion Injury in Pigs
Autor: Saku Ruohonen, Juhani Knuuti, Antti Saraste, Pekka Taimen, Christoffer Stark, Markus Malmberg, Juho Jalkanen, Tommi Vähäsilta, Matti Savo, Tero-Pekka Alastalo, Timo Savunen, Rasmus Kentala, Mikko Helenius, Juha Koskenvuo, Ville-Veikko Hynninen, Miikka Tarkia
Publikováno v: Frontiers in Pharmacology
The use of cardiopulmonary bypass (CPB) and aortic cross-clamping causes myocardial ischemia-reperfusion injury (I-RI) and can lead to reduced postoperative cardiac function. We investigated whether this injury could be attenuated by thymosin beta 4
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67b92624dab4eed9879e5625a114cbe9
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