Zobrazeno 1 - 10
of 452
pro vyhledávání: '"Mikko Hallman"'
Autor:
Pinja Tissarinen, Heli Tiensuu, Antti M. Haapalainen, Eveliina Ronkainen, Liisa Laatio, Marja Vääräsmäki, Hanna Öhman, Mikko Hallman, Mika Rämet
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)
Abstract Currently, there are no accurate means to predict spontaneous preterm birth (SPTB). Recently, we observed low expression of alpha-1 antitrypsin (AAT) in SPTB placentas. Present aim was to compare the concentrations of maternal serum AAT in p
Externí odkaz:
https://doaj.org/article/bf2b0d178d8d43c3b6ecda17d5dda599
Autor:
Anu Pasanen, Minna K Karjalainen, FinnGen, Ge Zhang, Heli Tiensuu, Antti M Haapalainen, Marja Ojaniemi, Bjarke Feenstra, Bo Jacobsson, Aarno Palotie, Hannele Laivuori, Louis J Muglia, Mika Rämet, Mikko Hallman
Publikováno v:
PLoS Genetics, Vol 19, Iss 10, p e1010982 (2023)
BackgroundPreterm birth (MethodsWe conducted a genome-wide meta-analysis of gestational duration and spontaneous preterm birth in 68,732 and 98,370 European mothers, respectively.ResultsThe meta-analysis detected 15 loci associated with gestational d
Externí odkaz:
https://doaj.org/article/f14300073a8b497a870ffbbe353c0e10
Autor:
Antti Tallgren, Leo Kager, Gina O’Grady, Hannu Tuominen, Jarmo Körkkö, Outi Kuismin, Martha Feucht, Callum Wilson, Jana Behunova, Eleina England, Mitja I. Kurki, Aarno Palotie, Mikko Hallman, Riitta Kaarteenaho, Franco Laccone, Kaan Boztug, Reetta Hinttala, Johanna Uusimaa
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
PurposeFINCA disease (Fibrosis, Neurodegeneration and Cerebral Angiomatosis, OMIM 618278) is an infantile-onset neurodevelopmental and multiorgan disease. Since our initial report in 2018, additional patients have been described. FINCA is the first h
Externí odkaz:
https://doaj.org/article/a15fd5005cc54d2da58d74123763ff5c
Human placental proteomics and exon variant studies link AAT/SERPINA1 with spontaneous preterm birth
Autor:
Heli Tiensuu, Antti M. Haapalainen, Pinja Tissarinen, Anu Pasanen, Tomi A. Määttä, Johanna M. Huusko, Steffen Ohlmeier, Ulrich Bergmann, Marja Ojaniemi, Louis J. Muglia, Mikko Hallman, Mika Rämet
Publikováno v:
BMC Medicine, Vol 20, Iss 1, Pp 1-23 (2022)
Abstract Background Preterm birth is defined as live birth before 37 completed weeks of pregnancy, and it is a major problem worldwide. The molecular mechanisms that lead to onset of spontaneous preterm birth are incompletely understood. Prediction a
Externí odkaz:
https://doaj.org/article/04242490e6fe48ffa80aef8110c60e46
Autor:
Johanna M. Huusko, Heli Tiensuu, Antti M. Haapalainen, Anu Pasanen, Pinja Tissarinen, Minna K. Karjalainen, Ge Zhang, Kaare Christensen, Kelli K. Ryckman, Bo Jacobsson, Jeffrey C. Murray, Stephen F. Kingsmore, Mikko Hallman, Louis J. Muglia, Mika Rämet
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Heat shock proteins are involved in the response to stress including activation of the immune response. Elevated circulating heat shock proteins are associated with spontaneous preterm birth (SPTB). Intracellular heat shock proteins act as m
Externí odkaz:
https://doaj.org/article/f305df8cd6b34e51b15c496289d931fa
Autor:
Anniina E. Hiltunen, Salla M. Kangas, Steffen Ohlmeier, Ilkka Pietilä, Jori Hiltunen, Heikki Tanila, Colin McKerlie, Subashika Govindan, Hannu Tuominen, Riitta Kaarteenaho, Mikko Hallman, Johanna Uusimaa, Reetta Hinttala
Publikováno v:
Molecular Medicine, Vol 26, Iss 1, Pp 1-16 (2020)
Abstract Background FINCA disease is a pediatric cerebropulmonary disease caused by variants in the NHL repeat-containing 2 (NHLRC2) gene. Neurological symptoms are among the first manifestations of FINCA disease, but the consequences of NHLRC2 defic
Externí odkaz:
https://doaj.org/article/49cbc6b319124640b45364e90fbbfc8c
Publikováno v:
Frontiers in Pediatrics, Vol 10 (2022)
The present review considers some controversial management practices during extremely premature perinatal transition. We focus on perinatal prevention and treatment of respiratory distress syndrome (RDS) in immature infants. New concerns regarding an
Externí odkaz:
https://doaj.org/article/fa774fe0b73f427dbd14edf6c5478424
Autor:
Anisur Rahman, Fyezah Jehan, Ana Alfirevic, Kenneth Maleta, Ulla Ashorn, Per Ashorn, Kelli K Ryckman, Tahmeed Ahmed, Usha Dhingra, Arup Dutta, Saikat Deb, Sunil Sazawal, Rajiv Bahl, Salahuddin Ahmed, Stephen H Kennedy, Monjur Rahman, Jesmin Pervin, Cathrine Hoyo, Rasheda Khanam, Sayedur Rahman, James A Litch, Aneeta Hotwani, Daniel E Roth, Ge Zhang, Abdullah Al Mahmud, Mikko Hallman, Huan Xu, Usma Mehmood, Zarko Alfirevic, Jeffrey C Murray, Bellington Vwalika, Susan Murphy, Patrick Musonda, Nagendra Monangi, Angharad Care, Fahad Aftab, Waqasuddin Khan, Joan T Price, Yuemei Fan, Thanh Q Le, Julio A Landero, Gerald F Combs, Elizabeth Belling, Joanne Chappell, Fansheng Kong, Criag Lacher, Nabidul Haque Chowdhury, Furqan Kabir, Imran Nisar, Ambreen Nizar, Javairia Khalid, Said Ali, Mohammed Hamad Juma, Md Munirul Islam, Laura Goodfellow, Juhi K Gupta, Larry Rand, Courtney Baruch-Gravett, Abdullah Baqui, Jane Hirst, Laura L Jelliffe-Pawlowski, Jeffrey Stringer, Louis Muglia
Publikováno v:
BMJ Global Health, Vol 6, Iss 9 (2021)
Background Selenium (Se), an essential trace mineral, has been implicated in preterm birth (PTB). We aimed to determine the association of maternal Se concentrations during pregnancy with PTB risk and gestational duration in a large number of samples
Externí odkaz:
https://doaj.org/article/1f235ae3017d4e429794289a5fb9ed16
Autor:
Jing Chen, Jonas Bacelis, Pol Sole-Navais, Amit Srivastava, Julius Juodakis, Amy Rouse, Mikko Hallman, Kari Teramo, Mads Melbye, Bjarke Feenstra, Rachel M Freathy, George Davey Smith, Deborah A Lawlor, Jeffrey C Murray, Scott M Williams, Bo Jacobsson, Louis J Muglia, Ge Zhang
Publikováno v:
PLoS Medicine, Vol 17, Iss 8, p e1003305 (2020)
BackgroundMany maternal traits are associated with a neonate's gestational duration, birth weight, and birth length. These birth outcomes are subsequently associated with late-onset health conditions. The causal mechanisms and the relative contributi
Externí odkaz:
https://doaj.org/article/b5bb6856719c4cbca033102f463bf5c0
CPPED1-targeting microRNA-371a-5p expression in human placenta associates with spontaneous delivery.
Publikováno v:
PLoS ONE, Vol 15, Iss 6, p e0234403 (2020)
MicroRNAs (miRNAs) are important regulators of gene expression, and their expression is associated with many physiological conditions. Here, we investigated potential associations between expression levels of miRNAs in human placenta and the onset of
Externí odkaz:
https://doaj.org/article/1631a2db7ab94968adf0fcccbe28a54f