Zobrazeno 1 - 10
of 270
pro vyhledávání: '"Mikko, Koskinen"'
Publikováno v:
Veterinary Medicine and Science, Vol 9, Iss 4, Pp 1584-1591 (2023)
Abstract Background Ropinirole has been shown to provoke vomiting in dogs by activating the dopamine D2‐like receptors in the chemoreceptor trigger zone. In humans, ropinirole is metabolized primarily by CYP1A2. Corresponding dog CYP1A2 is known to
Externí odkaz:
https://doaj.org/article/05a1746ba24849b0af1bea6495556886
Publikováno v:
Basic & Clinical Pharmacology & Toxicology. Jun2023 Supplement 1, Vol. 132, p3-26. 24p.
Autor:
Päivi Taavitsainen, Hille Gieschen, Christian Zurth, Mikko Koskinen, Clemens-Jeremias von Bühler, Karsten Denner, Annamari Vuorela, Michael Niehues, Timo Korjamo, Natalia A. Jungmann, Marja Kähkönen, Pirjo Nykänen, Olaf Prien
Publikováno v:
Drug Metabolism and Disposition. 49:420-433
The biotransformation and excretion of darolutamide were investigated in a phase I study. Six healthy male volunteers received a single dose of 300 mg 14C-darolutamide as an oral solution in the fasted state. Plasma, urine, and feces samples were ana
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b42599ea99983d8c72a5a26ff4bf32e
https://doi.org/10.1124/dmd.120.000309
https://doi.org/10.1124/dmd.120.000309
Autor:
Shouming, Wang, Anssi, Haikarainen, Antti, Pohjakallio, Julius, Sipilä, Janne, Kaskinoro, Satu, Juhila, Niina, Jalava, Mikko, Koskinen, Marja, Vesajoki, Esa, Kumpulainen, Jarmo, Pystynen, Tuula, Koskelainen, Patrik, Holm, David, Din Belle
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 77:129005
Here is reported the design and synthesis of a series of highly potent and selective α2C antagonists using benzodioxine methyl piperazine as a central scaffold by pharmacophoric analysis to improve the pharmacokinetics of suboptimal clinical candida
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a79817adb5e1c73186ea6f167f3ba422
https://doi.org/10.1016/j.bmcl.2022.129005
https://doi.org/10.1016/j.bmcl.2022.129005
Autor:
Christian Zurth, Pirjo Nykänen, Gary Wilkinson, Päivi Taavitsainen, Annamari Vuorela, Funan Huang, Susanne Reschke, Mikko Koskinen
Publikováno v:
Clinical pharmacokinetics. 61(4)
Darolutamide is a second-generation androgen receptor inhibitor approved for the treatment of nonmetastatic castration-resistant prostate cancer at a dosage of 600 mg orally twice daily.We aimed to fully characterize the pharmacokinetic profile of da
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a8e83925af555ebd4a186cd93810dd6
https://pubmed.ncbi.nlm.nih.gov/34866168
https://pubmed.ncbi.nlm.nih.gov/34866168
Autor:
Gary Wilkinson, Robert Fricke, Timo Korjamo, Mikko Koskinen, Olaf Prien, Hille Gieschen, Kristina Graudenz, Karsten Denner, Michaela Bairlein, Clemens-Jeremias Von Bühler, Christian Zurth
Publikováno v:
European Journal of Drug Metabolism and Pharmacokinetics
Background and Objectives Darolutamide is a novel androgen receptor (AR) antagonist approved for the treatment of nonmetastatic castration-resistant prostate cancer (nmCRPC). Accordingly, the drug–drug interaction (DDI) potential of darolutamide wa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1958f97ab799d34b65b089ca72f88b2
https://doi.org/10.1007/s13318-019-00577-5
https://doi.org/10.1007/s13318-019-00577-5
Autor:
Shouming, Wang, Anssi, Haikarainen, Antti, Pohjakallio, Julius, Sipilä, Janne, Kaskinoro, Satu, Juhila, Niina, Jalava, Mikko, Koskinen, Marja, Vesajoki, Esa, Kumpulainen, Jarmo, Pystynen, Tuula, Koskelainen, Patrik, Holm, David, Din Belle
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 69:128783
In this manuscript, we report a series of benzodioxine methyl piperidine derivatives as highly potent and selective α2C antagonists by ligand design to improve the pharmacokinetics of a previous candidate molecule.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d11c0582b9e57eabdf758db92785f82e
https://doi.org/10.1016/j.bmcl.2022.128783
https://doi.org/10.1016/j.bmcl.2022.128783
Publikováno v:
Drug metabolism letters. 14(1)
Background: Saini et al. recently investigated the pharmacokinetics of darolutamide and its diastereomers in vitro and in vivo in Balb/c mice, reporting higher levels of (S,S)-darolutamide than (S,R)-darolutamide following intravenous or oral dosing,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea44c126bf405b634aca1db4e12a1874
https://pubmed.ncbi.nlm.nih.gov/32436836
https://pubmed.ncbi.nlm.nih.gov/32436836
Autor:
Päivi Taavitsainen, Michael Niehues, Olaf Prien, Hille Gieschen, Mikko Koskinen, Chira Malmström, Steffen Sandmann, Timo Korjamo, Wiebke Janssen, Marja Kähkönen
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 50(8)
1. Darolutamide is a novel selective androgen receptor antagonist consisting of two pharmacologically equipotent diastereoisomers. The absorption, distribution, metabolism and excretion properties of darolutamide in rats are reported.2. Non- or [
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc07f906daf87c912ef246192fe07225
https://pubmed.ncbi.nlm.nih.gov/32003293
https://pubmed.ncbi.nlm.nih.gov/32003293
Autor:
Hannah Batchelor, Sandra Klein, Rick Greupink, Saskia N. de Wildt, Anna Lena Ungell, Talia Flanagan, Mikko Koskinen, Ina Gesquiere, Christine M. Madla, Daniel Keszthelyi, Miriam G. Mooij, Neil Parrott, Patrick Augustijns, Abdul Basit, Cordula Stillhart, Katarina Vučićević, Goran Miljuš, Anette Müllertz, Mine Orlu, Christophe Matthys
Publikováno v:
European Journal of Pharmaceutical Sciences, 147. Elsevier
European Journal of Pharmaceutical Sciences
European Journal of Pharmaceutical Sciences, 147
Web of Science
Stillhart, C, Vucicevic, K, Augustijns, P, Basit, A W, Batchelor, H, Flanagan, T R, Gesquiere, I, Greupink, R, Keszthelyi, D, Koskinen, M, Madla, C M, Matthys, C, Miljus, G, Mooij, M G, Parrott, N, Ungell, A-L, de Wildt, S N, Orlu, M, Klein, S & Mullertz, A 2020, ' Impact of gastrointestinal physiology on drug absorption in special populations – An UNGAP review ', European Journal of Pharmaceutical Sciences, vol. 147, 105280 . https://doi.org/10.1016/j.ejps.2020.105280
European Journal of Pharmaceutical Sciences
European Journal of Pharmaceutical Sciences, 147
Web of Science
Stillhart, C, Vucicevic, K, Augustijns, P, Basit, A W, Batchelor, H, Flanagan, T R, Gesquiere, I, Greupink, R, Keszthelyi, D, Koskinen, M, Madla, C M, Matthys, C, Miljus, G, Mooij, M G, Parrott, N, Ungell, A-L, de Wildt, S N, Orlu, M, Klein, S & Mullertz, A 2020, ' Impact of gastrointestinal physiology on drug absorption in special populations – An UNGAP review ', European Journal of Pharmaceutical Sciences, vol. 147, 105280 . https://doi.org/10.1016/j.ejps.2020.105280
The release and absorption profile of an oral medication is influenced by the physicochemical properties of the drug and its formulation, as well as by the anatomy and physiology of the gastrointestinal (GI) tract. During drug development the bioavai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b41cdfd2e1abbc3a56d476417e914b82
https://pure.eur.nl/en/publications/a4c271a5-3a71-4f4c-a4ce-8319d2b6b63c
https://pure.eur.nl/en/publications/a4c271a5-3a71-4f4c-a4ce-8319d2b6b63c
