Zobrazeno 1 - 8 of 8 pro vyhledávání: '"Mikkelsen GK"'
1
Akademický článek
Design and Synthesis of Pyrrolo[2,3- d ]pyrimidine-Derived Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitors Using a Checkpoint Kinase 1 (CHK1)-Derived Crystallographic Surrogate.
Autor: Williamson DS; Vernalis (R&D) Ltd., Granta Park, Great Abington, Cambridge CB21 6GB, U.K., Smith GP; H. Lundbeck A/S, Ottiliavej 9, 2500 Valby, Denmark., Mikkelsen GK; H. Lundbeck A/S, Ottiliavej 9, 2500 Valby, Denmark., Jensen T; H. Lundbeck A/S, Ottiliavej 9, 2500 Valby, Denmark., Acheson-Dossang P; Vernalis (R&D) Ltd., Granta Park, Great Abington, Cambridge CB21 6GB, U.K., Badolo L; H. Lundbeck A/S, Ottiliavej 9, 2500 Valby, Denmark., Bedford ST; Vernalis (R&D) Ltd., Granta Park, Great Abington, Cambridge CB21 6GB, U.K., Chell V; Vernalis (R&D) Ltd., Granta Park, Great Abington, Cambridge CB21 6GB, U.K., Chen IJ; Vernalis (R&D) Ltd., Granta Park, Great Abington, Cambridge CB21 6GB, U.K., Dokurno P; Vernalis (R&D) Ltd., Granta Park, Great Abington, Cambridge CB21 6GB, U.K., Hentzer M; H. Lundbeck A/S, Ottiliavej 9, 2500 Valby, Denmark., Newland S; Vernalis (R&D) Ltd., Granta Park, Great Abington, Cambridge CB21 6GB, U.K., Ray SC; Vernalis (R&D) Ltd., Granta Park, Great Abington, Cambridge CB21 6GB, U.K., Shaw T; Vernalis (R&D) Ltd., Granta Park, Great Abington, Cambridge CB21 6GB, U.K., Surgenor AE; Vernalis (R&D) Ltd., Granta Park, Great Abington, Cambridge CB21 6GB, U.K., Terry L; Vernalis (R&D) Ltd., Granta Park, Great Abington, Cambridge CB21 6GB, U.K., Wang Y; Vernalis (R&D) Ltd., Granta Park, Great Abington, Cambridge CB21 6GB, U.K., Christensen KV; H. Lundbeck A/S, Ottiliavej 9, 2500 Valby, Denmark.
Publikováno v: Journal of medicinal chemistry [J Med Chem] 2021 Jul 22; Vol. 64 (14), pp. 10312-10332. Date of Electronic Publication: 2021 Jun 29.
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2
Akademický článek
The design and SAR of a novel series of 2-aminopyridine based LRRK2 inhibitors.
Autor: Smith GP; H. Lundbeck A/S, Ottiliavej 9, 2500 Valby, Denmark. Electronic address: gsm@lundbeck.com., Badolo L; H. Lundbeck A/S, Ottiliavej 9, 2500 Valby, Denmark., Chell V; Vernalis (R&D) Ltd., Granta Park, Great Abington, Cambridge CB21 6GB, United Kingdom., Chen IJ; Vernalis (R&D) Ltd., Granta Park, Great Abington, Cambridge CB21 6GB, United Kingdom., Christensen KV; H. Lundbeck A/S, Ottiliavej 9, 2500 Valby, Denmark., David L; H. Lundbeck A/S, Ottiliavej 9, 2500 Valby, Denmark., Daechsel JA; H. Lundbeck A/S, Ottiliavej 9, 2500 Valby, Denmark., Hentzer M; H. Lundbeck A/S, Ottiliavej 9, 2500 Valby, Denmark., Herzig MC; H. Lundbeck A/S, Ottiliavej 9, 2500 Valby, Denmark., Mikkelsen GK; H. Lundbeck A/S, Ottiliavej 9, 2500 Valby, Denmark., Watson SP; H. Lundbeck A/S, Ottiliavej 9, 2500 Valby, Denmark., Williamson DS; Vernalis (R&D) Ltd., Granta Park, Great Abington, Cambridge CB21 6GB, United Kingdom.
Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2017 Sep 15; Vol. 27 (18), pp. 4500-4505. Date of Electronic Publication: 2017 Aug 01.
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3
Akademický článek
Synthesis and SAR studies of analogues of 4-(3,3-dimethyl-butyrylamino)-3,5-difluoro-N-thiazol-2-yl-benzamide (Lu AA41063) as adenosine A2A receptor ligands with improved aqueous solubility.
Autor: Mikkelsen GK; Department of Discovery Chemistry & DMPK, H. Lundbeck A/S, 9 Ottiliavej, DK-2500 Valby, Denmark. Electronic address: gmi@lundbeck.com., Langgård M; Department of Discovery Chemistry & DMPK, H. Lundbeck A/S, 9 Ottiliavej, DK-2500 Valby, Denmark., Schrøder TJ; Department of Molecular Pharmacology, H. Lundbeck A/S, 9 Ottiliavej, DK-2500 Valby, Denmark., Kreilgaard M; Department of Discovery Chemistry & DMPK, H. Lundbeck A/S, 9 Ottiliavej, DK-2500 Valby, Denmark., Jørgensen EB; Biologics & Pharmaceutical Science Department, H. Lundbeck A/S, 9 Ottiliavej, DK-2500 Valby, Denmark., Brandt G; Argenta Discovery Ltd, 8-9 The Spire Green Centre, Harlow CM19 5TR, UK., Griffon Y; Argenta Discovery Ltd, 8-9 The Spire Green Centre, Harlow CM19 5TR, UK., Boffey R; Argenta Discovery Ltd, 8-9 The Spire Green Centre, Harlow CM19 5TR, UK., Bang-Andersen B; Department of Discovery Chemistry & DMPK, H. Lundbeck A/S, 9 Ottiliavej, DK-2500 Valby, Denmark.
Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2015 Mar 15; Vol. 25 (6), pp. 1212-6. Date of Electronic Publication: 2015 Feb 07.
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4
Akademický článek
Hit-to-lead investigation of a series of novel combined dopamine D2 and muscarinic M1 receptor ligands with putative antipsychotic and pro-cognitive potential.
Autor: Sams AG; Neuroscience Drug Discovery Denmark, H. Lundbeck A/S, Copenhagen-Valby, Denmark. anette.sams@leo-pharma.com, Larsen K, Mikkelsen GK, Hentzer M, Christoffersen CT, Jensen KG, Frederiksen K, Bang-Andersen B
Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2012 Aug 01; Vol. 22 (15), pp. 5134-40. Date of Electronic Publication: 2012 May 18.
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5
Akademický článek
Efficacy switching SAR of mGluR5 allosteric modulators: highly potent positive and negative modulators from one chemotype.
Autor: Sams AG; Discovery Chemistry and DMPK, H. Lundbeck A/S, Ottiliavej 9, DK-2500 Valby, Denmark., Mikkelsen GK, Brodbeck RM, Pu X, Ritzén A
Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2011 Jun 01; Vol. 21 (11), pp. 3407-10. Date of Electronic Publication: 2011 Apr 05.
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6
Akademický článek
Discovery of phosphoric acid mono-{2-[(E/Z)-4-(3,3-dimethyl-butyrylamino)-3,5-difluoro-benzoylimino]-thiazol-3-ylmethyl} ester (Lu AA47070): a phosphonooxymethylene prodrug of a potent and selective hA(2A) receptor antagonist.
Autor: Sams AG; Medicinal Chemistry Research, Lundbeck Research Denmark, H. Lundbeck A/S, Ottiliavej 9, DK-2500 Copenhagen Valby, Denmark. anette.sams@leo-pharma.com, Mikkelsen GK, Larsen M, Langgård M, Howells ME, Schrøder TJ, Brennum LT, Torup L, Jørgensen EB, Bundgaard C, Kreilgård M, Bang-Andersen B
Publikováno v: Journal of medicinal chemistry [J Med Chem] 2011 Feb 10; Vol. 54 (3), pp. 751-64. Date of Electronic Publication: 2011 Jan 06.
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7
Akademický článek
Discovery of N-{1-[3-(3-oxo-2,3-dihydrobenzo[1,4]oxazin-4-yl)propyl]piperidin-4-yl}-2-phenylacetamide (Lu AE51090): an allosteric muscarinic M1 receptor agonist with unprecedented selectivity and procognitive potential.
Autor: Sams AG; Medicinal Chemistry Research, Lundbeck Research Denmark, H. Lundbeck A/S, Ottiliavej 9, DK-2500 Valby, Denmark. anette.sams@leo-pharma.com, Hentzer M, Mikkelsen GK, Larsen K, Bundgaard C, Plath N, Christoffersen CT, Bang-Andersen B
Publikováno v: Journal of medicinal chemistry [J Med Chem] 2010 Sep 09; Vol. 53 (17), pp. 6386-97.
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8
Akademický článek
Hit-to-lead optimization of a series of carboxamides of ethyl 2-amino-4-phenylthiazole-5-carboxylates as novel adenosine A2A receptor antagonists.
Autor: Sams AG; Medicinal Chemistry Research, H. Lundbeck A/S, Valby, Denmark. anette.sams@leo-pharma.com, Mikkelsen GK, Larsen M, Torup L, Brennum LT, Schrøder TJ, Bang-Andersen B
Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2010 Sep 01; Vol. 20 (17), pp. 5241-4. Date of Electronic Publication: 2010 Jul 24.
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