Výsledky vyhledávání - "Mikkel Thaning"

[18F]GE-180: A novel fluorine-18 labelled PET tracer for imaging Translocator protein 18kDa (TSPO)

Autor: Wai-Fung Chau, Dimitrios Mantzilas, Naghmeh Fouladi, Mikkel Thaning, Paul A. Jones, William Trigg, Veronique Morisson-Iveson, Ingvil Gausemel, Clare Durrant, Imtiaz Khan, Andrew Black, Joanna Passmore, Michelle Avory, Dennis O'shea, Harry John Wadsworth, Amanda Ewan, Duncan Wynn

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 22:1308-1313

A series of tricyclic compounds have been synthesised and evaluated in vitro for affinity against Translocator protein 18 kDa (TSPO) and for preferred imaging properties. The most promising of the compounds were radiolabelled and evaluated in vivo to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d9f7aae2c6ef9e829fccfa42f32630ad
https://doi.org/10.1016/j.bmcl.2011.12.084

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An improved, regioselective synthesis of the radiolabelling precursor for the translocator protein targeting positron emission tomography imaging radiotracer [18F]GE-180

Autor: Veronique Morisson-Iveson, Amanda Ewan, Sondre Nilsen, Joanna Passmore, Harry John Wadsworth, William Trigg, Mikkel Thaning

Publikováno v: Tetrahedron Letters. 55:5141-5143

[18F]GE-180 has been demonstrated to be a promising new positron emission tomography radiotracer for targeting translocator protein. PET imaging of TSPO will enable measurement of neuroinflammation and microglia activity in vivo. The synthetic route

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dfdc7f81d392cde00407bac438d33d76
https://doi.org/10.1016/j.tetlet.2014.07.090

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GE-145, a new low-osmolar dimeric radiographic contrast medium

Autor: Line Roed, Paul Evans, Andreas Gram, Inger Oulie, Henrik Rasmussen, Ben Newton, Lars-G. Wistrand, Derek Grant, Gunnar Hagelin, Peter Iveson, Mikkel Thaning, Astri Rogstad

Publikováno v: Acta Radiologica. 51:1014-1020

Background: Contrast-induced nephrotoxicity is a significant risk when using radiographic contrast media clinically, especially in high risk patients. Consequently, there is a need for a new contrast agent with improved clinical safety with regards t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d468e46ccee012eab93811348b96604
https://doi.org/10.3109/02841851.2010.509739

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Rhodium(I) hydrogenation in water: Kinetic studies and the detection of an intermediate using 13C{1H} PHIP NMR spectroscopy

Autor: Mårten S. G. Ahlquist, Magnus Karlsson, Mikkel Thaning, Oskar Axelsson, Mikaela Gustafsson, Ola F. Wendt

Publikováno v: Inorganica Chimica Acta. 360:1621-1627

The mechanism for hydrogenation of dimethylmaleate in water using cationic rhodium complexes with water-soluble bi-dentate phosphines has been investigated using kinetics and a novel method for the indirect detection of intermediates in catalytic hyd

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::023a1dd8fc09442ed4952ce0aeec194e
https://doi.org/10.1016/j.ica.2006.08.042

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Real-time metabolic imaging

Autor: Mikkel Thaning, René in ‘t Zandt, Klaes Golman

Publikováno v: Proceedings of the National Academy of Sciences. 103:11270-11275

The endogenous substance pyruvate is of major importance to maintain energy homeostasis in the cells and provides a window to several important metabolic processes essential to cell survival. Cell viability is therefore reflected in the metabolism of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29542f91cbaf8326c547d3577419653a
https://doi.org/10.1073/pnas.0601319103

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Increase in signal-to-noise ratio of > 10,000 times in liquid-state NMR

Autor: Jan Henrik Ardenkjær-Larsen, Mikkel Thaning, Björn Fridlund, Andreas Gram, Lennart Hansson, Georg Hansson, Mathilde H. Lerche, Klaes Golman, Rolf Servin

Publikováno v: Proceedings of the National Academy of Sciences. 100:10158-10163

A method for obtaining strongly polarized nuclear spins in solution has been developed. The method uses low temperature, high magnetic field, and dynamic nuclear polarization (DNP) to strongly polarize nuclear spins in the solid state. The solid samp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c609ba4950d0db317481f5e0b776f4ef
https://doi.org/10.1073/pnas.1733835100

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[¹⁸F]GE-180: a novel fluorine-18 labelled PET tracer for imaging Translocator protein 18 kDa (TSPO)

Autor: Harry, Wadsworth, Paul A, Jones, Wai-Fung, Chau, Clare, Durrant, Naghmeh, Fouladi, Joanna, Passmore, Dennis, O'Shea, Duncan, Wynn, Veronique, Morisson-Iveson, Amanda, Ewan, Mikkel, Thaning, Dimitrios, Mantzilas, Ingvil, Gausemel, Imtiaz, Khan, Andrew, Black, Michelle, Avory, William, Trigg

Publikováno v: Bioorganicmedicinal chemistry letters. 22(3)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1265dd2071e904eee4ac03f9e25dc25a
https://pubmed.ncbi.nlm.nih.gov/22244939

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Increase of signal-to-noise of more than 10,000 times in liquid state NMR

Autor: Jan H, Ardenkjær-Larsen, Klaes, Golman, Andreas, Gram, Mathilde H, Lerche, Rolf, Servin, Mikkel, Thaning, Jan, Wolber

Publikováno v: Discovery medicine. 3(19)

Extract: Two major applications exist for Nuclear Magnetic Resonance (NMR): spectroscopy and imaging. NMR spectroscopy has gained acceptance as one of the major analytical techniques, due to the detailed information that can be obtained about molecul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1e82f2941495aebb74b0a8d1cd43d8b1
https://pubmed.ncbi.nlm.nih.gov/20705036

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Method of producing a composition, composition and its use

Autor: Mikkel Thaning, Zandt, Rene In T., Jan Henrik Ardenkjær-Larsen, Wolber, J., Mathilde Hauge Lerche

Publikováno v: Thaning, M, in't Zandt, R, Ardenkjær-Larsen, J H, Wolber, J & Lerche, M H Apr. 30 2007, Method of producing a composition, composition and its use, Patent No. NO20071091, IPC No. A61B5/055; A61K49/06; A61K49/10; C07D519/00 .
Technical University of Denmark Orbit

The invention relates to a method of producing a composition comprising hyperpolarised 13C-pyruvate, the composition and its use as an imaging agent for MR imaging.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::42b8ae8e315d455558ebcf3f032b20dd
http://orbit.dtu.dk/ws/files/158700900/NO20071091A.pdf

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