SARS-CoV-2 detection using reverse transcription strand invasion based amplification and a portable compact size instrument

Autor: Maiken W. Rosenstierne, Shreya Joshi, E. Thomas Danielsen, Helen Webb, Dac Mui Luong, Julie Bjerring, Julie Hindkær, Lærke Jørgensen, Julie Blauenfeldt, Ask Bojesen, Flemming Holck, Johnny Weber Lau, Lars Bangsgaard, Jakob Broberg Lind, Mette Bjergaard Dragheim, Mikkel Rohde Jacobsen, Robert Elkjær, Steven Clauwaert, Kristina Christensen, Charlotta Polacek, Anders Fomsgaard, Tuomas Ojalehto, Antti Tullila, Mirko Brummer, Claus Juel Jensen, Frederikke Holm Jensen, Uffe Vest Schneider, Jan Gorm Lisby, Rikke Lind Jørgensen, Thomas Warthoe, Ebbe Finding, Peter Warthoe

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)

Abstract Rapid nucleic-acid based tests that can be performed by non-professionals outside laboratory settings could help the containment of the pandemic SARS-CoV-2 virus and may potentially prevent further widespread lockdowns. Here, we present a no

Externí odkaz: https://doaj.org/article/25d80698bbbf407eaa50e519561d61dc

SARS-CoV-2 detection using reverse transcription strand invasion based amplification and a portable compact size instrument

Autor: Frederikke Holm Jensen, Mirko Brummer, Julie Hindkær, Ebbe Finding, Peter Warthoe, Tuomas Ojalehto, Jakob Broberg Lind, Uffe Vest Schneider, Steven Clauwaert, Mette Bjergaard Dragheim, Julie Bjerring, Jan Gorm Lisby, Kristina Christensen, Antti Tullila, Helen Webb, Claus Juel Jensen, E. Thomas Danielsen, Charlotta Polacek, Mikkel Rohde Jacobsen, Maiken Worsøe Rosenstierne, Anders Fomsgaard, Robert Elkjær, Johnny Weber Lau, Shreya Joshi, Julie Blauenfeldt, Dac Mui Luong, Rikke Lind Jørgensen, Lars Bangsgaard, Lærke Jørgensen, Thomas Warthoe, Ask Bojesen, Flemming Holck

Publikováno v: Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)

Rapid nucleic-acid based tests that can be performed by non-professionals outside laboratory settings could help the containment of the pandemic SARS-CoV-2 virus and may potentially prevent further widespread lockdowns. Here, we present a novel compa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8389052b2cb353fa87b9296ca33d4e1b
http://europepmc.org/articles/PMC8593107

Cell death induced by cationic amphiphilic drugs depends on lysosomal Ca(2+) release and cyclic AMP

Autor: Kenji Maeda, Bin Liu, Jano Dicroce Giacobini, Mikkel Rohde, Marja Jäättelä, Atul Anand

Publikováno v: Mol Cancer Ther

Repurposing cationic amphiphilic drugs (CAD) for cancer treatment is emerging as an attractive means to enhance the efficacy of chemotherapy. Many commonly used CADs, including several cation amphiphilic antihistamines and antidepressants, induce can

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2052b49ffa5fe645225b515f7005c8ef
https://europepmc.org/articles/PMC7611280/

AMBRA1 links autophagy to cell proliferation and tumorigenesis by promoting c-MYC dephosphorylation and degradation

Autor: Cclaudia Fuoco, Daniela De Zio, Mikkel Rohde, María Salazar, Luisa Dalla Valle, Francesca Nazio, Valentina Cianfanelli, Mar Lorente, Matteo Bordi, Sabrina Di Bartolomeo, Mauro Piacentini, Manuela Antonioli, Fabio Quondamatteo, Francesco Cecconi, Guillermo Velasco, Gian Maria Fimia, Manuela Helmer-Citterich, Pier Federico Gherardini, Joern Dengjel, Christine Gretzmeier, Tatjana Skobo, Melania D'Orazio

Publikováno v: Nature cell biology
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid

Inhibition of a main regulator of cell metabolism, the protein kinase mTOR, induces autophagy and inhibits cell proliferation. However, the molecular pathways involved in the cross-talk between these two mTOR-dependent cell processes are largely unkn

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d7bf4b1f62463694dec7d8a4e4dbc34
http://europepmc.org/articles/PMC4976803

Heat shock protein 70 promotes cell survival by inhibiting lysosomal membrane permeabilization

Autor: Nicole Fehrenbacher, Maria Høyer-Hansen, Mikkel Rohde, Agnieszka Danielewicz, Ulrik Lademann, Marja Jäättelä, Mads Gyrd-Hansen, Jesper Nylandsted, Gabriele Multhoff, Ekkehard Weber

Publikováno v: The Journal of Experimental Medicine

Heat shock protein 70 (Hsp70) is a potent survival protein whose depletion triggers massive caspase-independent tumor cell death. Here, we show that Hsp70 exerts its prosurvival function by inhibiting lysosomal membrane permeabilization. The cell dea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3c3e0257a0879ef7716fb68e3c9beaa
https://doi.org/10.1084/jem.20040531