Polarized α-synuclein trafficking and transcytosis across brain endothelial cells via Rab7-decorated carriers

Autor: Parvez Alam, Mikkel R. Holst, Line Lauritsen, Janni Nielsen, Simone S. E. Nielsen, Poul Henning Jensen, Jonathan R. Brewer, Daniel E. Otzen, Morten S. Nielsen

Publikováno v: Fluids and Barriers of the CNS, Vol 19, Iss 1, Pp 1-12 (2022)

Abstract Parkinson’s disease is mainly caused by aggregation of α-synuclein (α-syn) in the brain. Exchange of α-syn between the brain and peripheral tissues could have important pathophysiological and therapeutic implications, but the traffickin

Externí odkaz: https://doaj.org/article/82b4322c12b3489790248a736a110a73

Vasopressin-Independent Regulation of Aquaporin-2 by Tamoxifen in Kidney Collecting Ducts

Autor: Stine Julie Tingskov, Hyo-Jung Choi, Mikkel R. Holst, Shan Hu, Chunling Li, Weidong Wang, Jørgen Frøkiær, Lene N. Nejsum, Tae-Hwan Kwon, Rikke Nørregaard

Publikováno v: Frontiers in Physiology, Vol 10 (2019)

Arginine vasopressin (AVP) mediates water reabsorption in the kidney collecting ducts through regulation of aquaporin-2 (AQP2). Also, estrogen has been known to regulate AQP2. Consistently, we previously demonstrated that tamoxifen (TAM), a selective

Externí odkaz: https://doaj.org/article/41b4fc3c33514cb58d811ce65c2fe4cd

Regulated exocytosis: Renal Aquaporin-2 3D Vesicular Network Organization and Association with F-actin

Autor: Ute Hahn, Jesse Aaron, Frédéric H. Login, Mikkel R. Holst, Louis Gammelgaard, Lene N. Nejsum, Sampavi Rajkumar

Publikováno v: Holst, M R, Jensen, L G, Aaron, J, Login, F H, Rajkumar, S, Hahn, U & Nejsum, L N 2021, ' Regulated exocytosis: Renal Aquaporin-2 3D Vesicular Network Organization and Association with F-actin ', American Journal of Physiology: Cell Physiology, vol. 321, no. 6, pp. 1060-1069 . https://doi.org/10.1152/ajpcell.00255.2021

Regulated vesicle exocytosis is a key response to extracellular stimuli in diverse physiological processes, including hormone regulated short-term urine concentration. In the renal collecting duct, the water channel aquaporin-2 (AQP2) localizes to th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ada1226d45ec1683da4fd96bfe26d4e2
https://pure.au.dk/portal/da/publications/regulated-exocytosis-renal-aquaporin2-3d-vesicular-network-organization-and-association-with-factin(5f231139-b81a-4dfc-bdac-a0ca5b3a7de1).html

Mapping Receptor Antibody Endocytosis and Trafficking in Brain Endothelial Cells

Autor: Mikkel R, Holst, Simone S E, Nielsen, Morten S, Nielsen

Publikováno v: Methods in molecular biology (Clifton, N.J.). 2367

Drug delivery to the brain is a tremendous problem for the academic society and the industry. One solution with a huge potential is to use endocytic receptors as carriers. Here we describe how endocytic activity and subcellular trafficking of a speci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::085f91ebe4e20d2d38d42e471351abf8
https://pubmed.ncbi.nlm.nih.gov/32813236

Vasopressin-Independent Regulation of Aquaporin-2 by Tamoxifen in Kidney Collecting Ducts

Autor: Chunling Li, Weidong Wang, Tae-Hwan Kwon, Hyo-Jung Choi, Lene N. Nejsum, Rikke Nørregaard, Shan Hu, Mikkel R. Holst, Jørgen Frøkiær, Stine Julie Tingskov

Publikováno v: Frontiers in Physiology, Vol 10 (2019)
Frontiers in Physiology
Tingskov, S J, Choi, H-J, Holst, M R, Hu, S, Li, C, Wang, W, Frokiaer, J, Nejsum, L N, Kwon, T-H & Norregaard, R 2019, ' Vasopressin-Independent Regulation of Aquaporin-2 by Tamoxifen in Kidney Collecting Ducts ', Frontiers in Physiology, vol. 10, 948, pp. 1-13 . https://doi.org/10.3389/fphys.2019.00948

Arginine vasopressin (AVP) mediates water reabsorption in the kidney collecting ducts through regulation of aquaporin-2 (AQP2). Also, estrogen has been known to regulate AQP2. Consistently, we previously demonstrated that tamoxifen (TAM), a selective

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05696d5f097c1784792c310607b31df9
https://www.frontiersin.org/article/10.3389/fphys.2019.00948/full