Evidence of steady-state fibroblast subtypes in the normal human breast as cells-of-origin for perturbed-state fibroblasts in breast cancer

Autor: Mikkel Morsing Bagger, Jonas Sjölund, Jiyoung Kim, Katharina Theresa Kohler, René Villadsen, Abbas Jafari, Moustapha Kassem, Kristian Pietras, Lone Rønnov-Jessen, Ole William Petersen

Publikováno v: Breast Cancer Research, Vol 26, Iss 1, Pp 1-19 (2024)

Abstract Background Human breast cancer most frequently originates within a well-defined anatomical structure referred to as the terminal duct lobular unit (TDLU). This structure is endowed with its very own lobular fibroblasts representing one out o

Externí odkaz: https://doaj.org/article/a46f3b614fcd4ea7b71577a94fffc26e

Fibroblasts direct differentiation of human breast epithelial progenitors

Autor: Mikkel Morsing, Jiyoung Kim, René Villadsen, Nadine Goldhammer, Abbas Jafari, Moustapha Kassem, Ole William Petersen, Lone Rønnov-Jessen

Publikováno v: Breast Cancer Research, Vol 22, Iss 1, Pp 1-16 (2020)

Abstract Background Breast cancer arises within specific regions in the human breast referred to as the terminal duct lobular units (TDLUs). These are relatively dynamic structures characterized by sex hormone driven cyclic epithelial turnover. TDLUs

Externí odkaz: https://doaj.org/article/c9aa0ba7b00c4ae5a501d55aaacad9f1

Oncogenic translation directs spliceosome dynamics revealing an integral role for SF3A3 in breast cancer

Autor: Johan Vallon-Christersson, Anna Ebbesson, Eugenia Cordero, Sowndarya Muthukumar, Roberto Munita, Giulia Beneventi, Karin Jirström, Kristina Lövgren, Terese Jönsson, Magdalena Madej, Ana Bosch, Maciej Cieśla, Álvaro Sejas Martinez, Mikkel Morsing, Björn Nodin, Ingrid Hedenfalk, Danny Incarnato, Cristian Bellodi, Johan Staaf, Phuong Cao Thi Ngoc, Kristian Pietras, Gabriella Honeth

Publikováno v: Molecular Cell, 81(7):j.molcel.2021.01.034, 1453-1468. CELL PRESS

Splicing is a central RNA-based process commonly altered in human cancers; however, how spliceosomal components are co-opted during tumorigenesis remains poorly defined. Here we unravel the core splice factor SF3A3 at the nexus of a translation-based

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9df2847fe43c27cd85566e4b0e55bf3a
https://research.rug.nl/en/publications/1055686c-7a3e-48d9-8536-000cc4379b5b

Publisher Correction: A CD146 FACS Protocol Enriches for Luminal Keratin 14/19 Double Positive Human Breast Progenitors

Autor: Ole W. Petersen, Jiyoung Kim, Agla J. Fridriksdottir, Lone Rønnov-Jessen, Mikkel Morsing, Vera Timmermans-Wielenga, Ólöf Gerdur Ísberg, René Villadsen

Publikováno v: Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-1 (2020)

Human breast cancer is believed to arise in luminal progenitors within the normal breast. A subset of these are double positive (DP) for basal and luminal keratins and localizes to a putative stem cell zone within ducts. We here present a new protoco

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44754a96864af3915a9fa53bc2534be7
http://europepmc.org/articles/PMC7066244

Proof of region-specific multipotent progenitors in human breast epithelia

Autor: Mikkel Morsing, Jiyoung Kim, René Villadsen, Agla J. Fridriksdottir, Ole W. Petersen, Lone Rønnov-Jessen, Marie Christine Klitgaard

Publikováno v: Fridriksdottir, A J, Villadsen, R, Morsing, M, Klitgaard, M C, Kim, J, Petersen, O W & Rønnov-Jessen, L 2017, ' Proof of region-specific multipotent progenitors in human breast epithelia ', Proceedings of the National Academy of Sciences of the United States of America, vol. 114, no. 47, pp. E10102–E10111 . https://doi.org/10.1073/pnas.1714063114
Proceedings of the National Academy of Sciences of the United States of America

Significance We have devised a culture system with conditions that allow primary breast myoepithelial cells (MEPs) to be passaged in a manner that sustains either nonmyodifferentiated or myodifferentiated cell populations without permitting contamina

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf58425153b0fe79324296ad2a541161
https://curis.ku.dk/ws/files/186749440/PNAS_2017_Fridriksdottir_E10102_11.pdf