Add-On MEmaNtine to Dopamine Antagonism to Improve Negative Symptoms at First Psychosis- the AMEND Trial Protocol

Autor: Katharina O. Sandström, Olga B. Baltzersen, Anouk Marsman, Cecilie K. Lemvigh, Vincent O. Boer, Kirsten B. Bojesen, Mette Ø. Nielsen, Henrik Lundell, Daban K. Sulaiman, Mikkel E. Sørensen, Birgitte Fagerlund, Adrienne C. Lahti, Warda T. Syeda, Christos Pantelis, Esben T. Petersen, Birte Y. Glenthøj, Hartwig R. Siebner, Bjørn H. Ebdrup

Publikováno v: Frontiers in Psychiatry, Vol 13 (2022)

BackgroundAntipsychotic drugs are primarily efficacious in treating positive symptoms by blocking the dopamine D2 receptor, but they fail to substantially improve negative symptoms and cognitive deficits. The limited efficacy may be attributed to the

Externí odkaz: https://doaj.org/article/7a6cb26b466540da85a27137a88213ec

Clustering of antipsychotic-naïve patients with schizophrenia based on functional connectivity from resting-state electroencephalography

Autor: Karen S. Ambrosen, Fanny Fredriksson, Simon Anhøj, Nikolaj Bak, Edwin van Dellen, Livia Dominicus, Cecilie K. Lemvigh, Mikkel E. Sørensen, Mette Ø. Nielsen, Kirsten B. Bojesen, Birgitte Fagerlund, Birte Y. Glenthøj, Bob Oranje, Lars K. Hansen, Bjørn H. Ebdrup

Publikováno v: European Archives of Psychiatry and Clinical Neuroscience.

Schizophrenia is associated with aberrations in the Default Mode Network (DMN), but the clinical implications remain unclear. We applied data-driven, unsupervised machine learning based on resting-state electroencephalography (rsEEG) functional conne

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7e5325f30915746df191af02435ae80b
https://doi.org/10.1007/s00406-023-01550-9

Lower Vitamin C Levels Are Associated With Less Improvement in Negative Symptoms in Initially Antipsychotic-Naïve Patients With First-Episode Psychosis

Autor: Anders N Myken, Bjørn H Ebdrup, Mikkel E Sørensen, Brian V Broberg, Martin W Skjerbæk, Birte Y Glenthøj, Jens Lykkesfeldt, Mette Ø Nielsen

Publikováno v: Myken, A N, Ebdrup, B H, Sørensen, M E, Broberg, B V, Skjerbæk, M W, Glenthøj, B Y, Lykkesfeldt, J & Nielsen, M 2022, ' Lower Vitamin C Levels Are Associated With Less Improvement in Negative Symptoms in Initially Antipsychotic-Naïve Patients With First-Episode Psychosis ', The international journal of neuropsychopharmacology, vol. 25, no. 8, pp. 613-618 . https://doi.org/10.1093/ijnp/pyac029

Low levels of vitamin C have been observed in patients with schizophrenia and psychosis, and vitamin C may affect the dopaminergic system. Likewise, antipsychotic medication modulates striatal dopamine D2 receptors. We measured vitamin C levels in 52

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30207d912bfe73e6fa26dd1d2ddfcba9
https://curis.ku.dk/portal/da/publications/lower-vitamin-c-levels-are-associated-with-less-improvement-in-negative-symptoms-in-initially-antipsychoticnaive-patients-with-firstepisode-psychosis(be76dbd1-617e-47d7-bfc0-f721d90b7ac5).html

Association of Structural Magnetic Resonance Imaging Measures With Psychosis Onset in Individuals at Clinical High Risk for Developing Psychosis:An ENIGMA Working Group Mega-analysis

Autor: Daniela Hubl, Hidenori Yamasue, Jan Ivar Røssberg, Christina Wenneberg, Cali F. Bartholomeusz, Tina Dam Kristensen, Paolo Fusar-Poli, Peter Bachman, Jessica A. Turner, Naoyuki Katagiri, Daiki Sasabayashi, Stefan Borgwardt, Dorte Nordholm, Michael W. L. Chee, Daniel H. Mathalon, Mathew A. Harris, Alison R. Yung, Sophia Vinogradov, Maria Jalbrzikowski, Mikkel E. Sørensen, Jayachandra Mitta Raghava, Franz Resch, Bjørn H Ebdrup, Therese van Amelsvoort, Paul M. Thompson, Rachel Loewy, Anastasia Theodoridou, Christine I. Hooker, Christian K. Tamnes, Rebecca Cooper, Masafumi Mizuno, Shinsuke Koike, Cheryl M. Corcoran, Maria A. Omelchenko, Florian Schlagenhauf, Michio Suzuki, Dennis Hernaus, Kang Ik K. Cho, Jordina Tor, Irina Lebedeva, Alex Koppel, Jinsong Tang, Lukasz Smigielski, Ole A. Andreassen, Lieuwe de Haan, Dean F. Salisbury, Birte Glenthøj, Yoo Bin Kwak, Tor Gunnar Værnes, Peter J. Uhlhaas, Adriana Fortea, Rebecca A. Hayes, Brian J. Roach, Lars T. Westlye, Inmaculada Baeza, Esther Via, Louise Birkedal Glenthøj, Patrick D. McGorry, Ingrid Agartz, Kimberley Atkinson, Kristen M. Haut, Mallory J Klaunig, Tsutomu Takahashi, Helen Baldwin, Chantal Michel, Gisela Sugranyes, Romina Mizrahi, James A. Waltz, Juan Zhou, Francisco Reyes-Madrigal, Jason Schiffman, Liu Yuan, G. Paul Amminger, Camilo de la Fuente-Sandoval, Theo G.M. van Erp, Jose C. Pariente, Dennis Velakoulis, Merete Nordentoft, Karsten Heekeren, Ying He, Minah Kim, Jochen Kindler, Ulrich Schall, Montserrat Dolz, Sabrina Catalano, Michael Kaess, Tomas Moncada-Habib, Wenche ten Velden Hegelstad, Wu Jeong Hwang, Jun Soo Kwon, Daniel Muñoz-Samons, André Schmidt, Holly K. Hamilton, Tiziano Colibazzi, Stephen J. Wood, Philip McGuire, Lijun Ouyang, Ashleigh Lin, Paul E. Rasser, Kiyoto Kasai, Wulf Rössler, Alexander Tomyshev, Vanessa Cropley, Shalaila S. Haas, Xiaoqian Ma, Pablo León-Ortiz, Ketil Oppedal, Paul Møller, Xiaogang Chen, Barnaby Nelson, Gloria D. Venegoni, Paul Allen, Christos Pantelis, Imke Lemmers-Jansen, Jimmy Chee Keong Lee, Takahiro Nemoto, Stephen M. Lawrie, Andreas Heinz

Publikováno v: ENIGMA Clinical High Risk for Psychosis Working Group 2021, ' Association of Structural Magnetic Resonance Imaging Measures With Psychosis Onset in Individuals at Clinical High Risk for Developing Psychosis : An ENIGMA Working Group Mega-analysis ', JAMA Psychiatry, vol. 78, no. 7, pp. 753-766 . https://doi.org/10.1001/jamapsychiatry.2021.0638
JAMA Psychiatry, 78(7), 753-766. American Medical Association
JAMA Psychiatry
JAMA psychiatry, 78(7), 753-766. American Medical Association
2021, ' Association of Structural Magnetic Resonance Imaging Measures With Psychosis Onset in Individuals at Clinical High Risk for Developing Psychosis : An ENIGMA Working Group Mega-analysis ', JAMA Psychiatry . https://doi.org/10.1001/jamapsychiatry.2021.0638

IMPORTANCE The ENIGMA clinical high risk (CHR) for psychosis initiative, the largest pooled neuroimaging sample of individuals at CHR to date, aims to discover robust neurobiological markers of psychosis risk.OBJECTIVE To investigate baseline structu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e0ad9a7ca33265b1633f7b648cd083a
https://hdl.handle.net/1871.1/3adcfd37-13e3-4d94-a692-43eaafabcf74

Poster #79 ASSOCIATION BETWEEN SENSORIMOTOR GATING AND MISMATCH NEGATIVITY

Autor: Bob Oranje, Mikkel E. Sørensen, Birte Glenthøj

Publikováno v: Schizophrenia Research. 136:S213

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6e0961224a24a398aa9bc8b5f2f09f29
https://doi.org/10.1016/s0920-9964(12)70651-5