Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Mikiyoshi Saito"'
Autor:
Mikiyoshi Saito
Publikováno v:
Folia Pharmacologica Japonica. 147:168-174
Autor:
Mikiyoshi Saito, Masahito Ebina, Erina Iwabuchi, Hironobu Sasano, Shuko Hata, Kazushige Mori, Sodai Narumi, Takashi Kondo, Yasuhiro Miki, Makoto Kobayashi, Hisafumi Yamada-Okabe, Chiaki Endo, Makoto Maemondo, Takashi Suzuki, Akira Inoue, Ikuro Sato, Masakazu Ichinose
Publikováno v:
The International Journal of Biological Markers. 30:234-242
Background Epidermal growth factor receptor (EGFR)–tyrosine kinase inhibitor (TKI) has demonstrated a promising therapeutic response in lung adenocarcinoma patients with EGFR gene mutations. However, the predictive factors for this therapy have not
A novel therapeutic approach for thrombocytopenia by minibody agonist of the thrombopoietin receptor
Autor:
Yuichi Hirata, Akihisa Kaneko, Kiyotaka Nakano, Takashi Yoshikubo, Hirofumi Sakumoto, Tetsuro Orita, Hiroyuki Tsunoda, Toshihiko Ohtomo, Masahiko Nanami, Naohiro Yabuta, Eiji Kumagai, Kouichiro Ono, Takeshi Yoshino, Masayuki Tsuchiya, Mikiyoshi Saito, Jun-ichi Nezu
Publikováno v:
Blood. 105:562-566
Antibodies have brought valuable therapeutics in the clinical treatment of various diseases without serious adverse effects through their intrinsic features such as specific binding to the target antigen with high affinity, clinical safety as serum p
Autor:
Takashi Kondo, Masahito Ebina, Kazushige Mori, Hironobu Sasano, Yasuhiro Miki, Erina Iwabuchi, Makoto Maemondo, Mikiyoshi Saito, Kaito Nihira, Hisafumi Yamada-Okabe, Ikuro Sato, Sodai Narumi, Kazue Ise, Shinya Iida, Katsuhiko Ono
Publikováno v:
The Journal of Pathology.
The development of therapeutic resistance to EGFR tyrosine kinase inhibitors (EGFR-TKIs, ie erlotinib or gefitinib) has been the major clinical problem when treating lung adenocarcinoma patients with these agents. However, its mechanisms have not nec
Autor:
Shinya, Iida, Yasuhiro, Miki, Takashi, Suzuki, Kazushige, Mori, Mikiyoshi, Saito, Hiromichi, Niikawa, Takashi, Kondo, Hisafumi, Yamada-Okabe, Hironobu, Sasano
Publikováno v:
Anticancer research. 34(4)
AXL (anexelekto) has been explored as a potential novel therapeutic target for non-small cell lung carcinoma (NSCLC) but its activation status has not been evaluated in NSCLC.We first immunolocalized the phosphorylated form of AXL in 112 lung adenoca
Autor:
Kaito, Nihira, Yasuhiro, Miki, Shinya, Iida, Sodai, Narumi, Katsuhiko, Ono, Erina, Iwabuchi, Kazue, Ise, Kazushige, Mori, Mikiyoshi, Saito, Masahito, Ebina, Ikuro, Sato, Makoto, Maemondo, Hisafumi, Yamada-Okabe, Takashi, Kondo, Hironobu, Sasano
Publikováno v:
The Journal of pathology. 234(2)
The development of therapeutic resistance to EGFR tyrosine kinase inhibitors (EGFR-TKIs, ie erlotinib or gefitinib) has been the major clinical problem when treating lung adenocarcinoma patients with these agents. However, its mechanisms have not nec
Autor:
Morimi Shimada, Mikiyoshi Saito, Masahiko Okuno, Masao Nakagawa, Keiko Yamauchi-Takihara, Shigemichi Hishinuma
Publikováno v:
Laboratory Investigation. 80:433-440
To determine the role of cytokines in acute myocarditis, we examined expressional patterns of cardiotrophin-1 (CT-1), TNF-alpha, and IL-1alpha in a murine model of acute myocarditis. Ten-day-old Institute of Cancer Research mice were injected with Co
Autor:
Hiroaki Kodama, Takahiro Kato, Motoaki Sano, Jing Pan, Keiichi Fukuda, Toshiyuki Takahashi, Satoshi Ogawa, Mikiyoshi Saito, Junichi Matsuzaki
Publikováno v:
Circulation Research. 84:1127-1136
Abstract —This study was designed to determine whether mechanical stretch activates the Janus kinase (JAK)/signal transducers and activators of transcription (STAT) pathway in cardiomyocytes and, if so, by what mechanism. Neonatal rat/murine cardio
Autor:
Nancy L. Lin, Norma E. Fox, Kenneth Kaushansky, Tetsuya Taga, Virginia C. Broudy, Mikiyoshi Saito
Publikováno v:
Blood. 88:2026-2032
Thrombopoietin (Tpo), the ligand for the c-Mpl receptor, is a major regulator of megakaryopoiesis. Treatment of mice with Tpo raises the platelet count fourfold within a few days. Conversely, c-mpl knock-out mice have platelet counts that are 15% tha
Autor:
Hong Zhou, Thomas J. Martin, Mikiyoshi Saito, T. Tamura, Nobuyuki Udagawa, Tatsuo Suda, Douglas J. Hilton, E. Romas, Kong Wah Ng, Tetsuya Taga
Publikováno v:
The Journal of Experimental Medicine
Interleukin (IL)-11 is a multifunctional cytokine whose role in osteoclast development has not been fully elucidated. We examined IL-11 production by primary osteoblasts and the effects of rat monoclonal anti-mouse glycoprotein 130 (gp130) antibody o