Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Mikiyo Nakata"'
Publikováno v:
Cell Reports, Vol 42, Iss 3, Pp 112284- (2023)
Summary: B cells generate functionally different classes of antibodies through class-switch recombination (CSR), which requires classical non-homologous end joining (C-NHEJ) to join the DNA breaks at the donor and acceptor switch (S) regions. We show
Externí odkaz:
https://doaj.org/article/9523c03dca4c4a5cb2f38c653370c63d
Autor:
Le Thi Huong, Maki Kobayashi, Mikiyo Nakata, Go Shioi, Hitoshi Miyachi, Tasuku Honjo, Hitoshi Nagaoka
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e61433 (2013)
The Aicda gene encodes activation-induced cytidine deaminase (AID). Aicda is strongly transcribed in activated B cells to diversify immunoglobulin genes, but expressed at low levels in various other cells in response to physiological or pathological
Externí odkaz:
https://doaj.org/article/a1d20213fb734c9fa0e2c24d7855589c
Autor:
Hongyan Qin, Keiichiro Suzuki, Mikiyo Nakata, Shunsuke Chikuma, Nakako Izumi, Le Thi Huong, Mikako Maruya, Sidonia Fagarasan, Meinrad Busslinger, Tasuku Honjo, Hitoshi Nagaoka
Publikováno v:
PLoS ONE, Vol 6, Iss 12, p e29141 (2011)
Activation-induced cytidine deaminase (AID), produced by the Aicda gene, is essential for the immunoglobulin gene (Ig) alterations that form immune memory. Using a Cre-mediated genetic system, we unexpectedly found CD4(+) T cells that had expressed A
Externí odkaz:
https://doaj.org/article/21bdde7dbf1646fe8566f589a732102e
Phf5a regulates DNA repair in class switch recombination via p400 and histone H2A variant deposition
Autor:
Afzal Husain, Andre Stanlie, Tasuku Honjo, Mikiyo Nakata, Hisaaki Taniguchi, Takako Taniguchi, Samiran Mondal, Farazul Haque, Nasim A. Begum
Publikováno v:
EMBO J
Antibody class switch recombination (CSR) is a locus-specific genomic rearrangement mediated by switch (S) region transcription, activation-induced cytidine deaminase (AID)-induced DNA breaks, and their resolution by non-homologous end joining (NHEJ)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92ab4d2e1541ad4729b379699080ec77
https://europepmc.org/articles/PMC8204862/
https://europepmc.org/articles/PMC8204862/
Autor:
Tasuku Honjo, Jiangliang Xu, Ji‐Yang Wang, Hodaka Fujii, Maki Kobayashi, Afzal Husain, Jan Rehwinkel, Mikiyo Nakata, Nasim A. Begum
Publikováno v:
EMBO J
Sterile alpha motif and histidine-aspartic acid domain-containing protein 1 (SAMHD1), a dNTP triphosphohydrolase, regulates the levels of cellular dNTPs through their hydrolysis. SAMHD1 protects cells from invading viruses that depend on dNTPs to rep
Publikováno v:
Journal of Biological Chemistry. 287:32415-32429
H3K4me3 plays a critical role in the activation-induced cytidine deaminase (AID)-induced DNA cleavage of switch (S) regions in the immunoglobulin heavy chain (IgH) locus during class-switch recombination (CSR). The histone chaperone complex facilitat
Autor:
Mikiyo Nakata, Kazuo Kinoshita, Hitoshi Nagaoka, Reiko Shinkura, Maki Kobayashi, Andre Stanlie, Yoko Kitawaki, Nasim A. Begum, Masamichi Muramatsu, Tomomitsu Doi, Tasuku Honjo, Lucia Kato, Il-mi Okazaki, Masatoshi Aida
Publikováno v:
Proceedings of the National Academy of Sciences. 106:22375-22380
To initiate class switch recombination (CSR) activation-induced cytidine deaminase (AID) induces staggered nick cleavage in the S region, which lies 5 to each Ig constant region gene and is rich in palindromic sequences. Topoisomerase 1 (Top1) contro
Publikováno v:
Proceedings of the National Academy of Sciences. 102:2022-2027
Activation-induced cytidine deaminase (AID) is required for the DNA cleavage step of Ig somatic hypermutation (SHM). However, its molecular mechanism is controversial. The RNA editing hypothesis postulates that AID deaminates cytosine in an unknown m
Autor:
Hong-Yan Qin, Mikako Maruya, Sidonia Fagarasan, Tasuku Honjo, Mikiyo Nakata, Shunsuke Chikuma, Nakako Izumi, Le Thi Huong, Hitoshi Nagaoka, Meinrad Busslinger, Keiichiro Suzuki
Publikováno v:
PLoS ONE
PLoS ONE, Vol 6, Iss 12, p e29141 (2011)
PLoS ONE, Vol 6, Iss 12, p e29141 (2011)
Activation-induced cytidine deaminase (AID), produced by the Aicda gene, is essential for the immunoglobulin gene (Ig) alterations that form immune memory. Using a Cre-mediated genetic system, we unexpectedly found CD4(+) T cells that had expressed A
Autor:
Reiko Shinkura, Thinh Huy Tran, Keiichiro Suzuki, Mikiyo Nakata, Tasuku Honjo, Sidonia Fagarasan, Hitoshi Nagaoka, Nasim A. Begum
Publikováno v:
Nature immunology. 11(2)
Activation-induced cytidine deaminase (AID) is essential for the generation of antibody memory but also targets oncogenes, among other genes. We investigated the transcriptional regulation of Aicda (which encodes AID) in class switch–inducible CH12