Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Mikiya Otsuji"'
Autor:
Yuya Terashima, Etsuko Toda, Meiji Itakura, Mikiya Otsuji, Sosuke Yoshinaga, Kazuhiro Okumura, Francis H. W. Shand, Yoshihiro Komohara, Mitsuhiro Takeda, Kana Kokubo, Ming-Chen Chen, Sana Yokoi, Hirofumi Rokutan, Yutaka Kofuku, Koji Ohnishi, Miki Ohira, Toshihiko Iizasa, Hirofumi Nakano, Takayoshi Okabe, Hirotatsu Kojima, Akira Shimizu, Shiro Kanegasaki, Ming-Rong Zhang, Ichio Shimada, Hiroki Nagase, Hiroaki Terasawa, Kouji Matsushima
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
The cytoplasmic protein FROUNT can bind to chemokine receptors and enhance chemokine signalling. Here, the authors show that inhibiting FROUNT in macrophages either by knockdown of the gene or using the anti-alcoholism drug disulfiram, results in a r
Externí odkaz:
https://doaj.org/article/a4d75cebbb8f47a985d666129063bb6d
Publikováno v:
PLoS Computational Biology, Vol 3, Iss 6, p e108 (2007)
Cell polarity is a general cellular process that can be seen in various cell types such as migrating neutrophils and Dictyostelium cells. The Rho small GTP(guanosine 5'-tri phosphate)ases have been shown to regulate cell polarity; however, its mechan
Externí odkaz:
https://doaj.org/article/d38687821a98475dab8fefeb1bf05b16
Publikováno v:
Journal of the Japanese Society of Intensive Care Medicine. 26:93-102
Autor:
Ju Mizuno, Yoshiki Hata, Kazuo Hanaoka, Takeshi Yokoyama, Mitsuru Ohishi, Yasuhiro Tanaka, Mikiya Otsuji, Hideko Arita, Yoshihiro Fukuoka
Publikováno v:
Gazzetta Medica Italiana Archivio per le Scienze Mediche. 179
Autor:
Sana Yokoi, Takayoshi Okabe, Ichio Shimada, Toshihiko Iizasa, Etsuko Toda, Koji Ohnishi, Francis H. W. Shand, Shiro Kanegasaki, Hiroki Nagase, Meiji Itakura, Hirofumi Nakano, Mitsuhiro Takeda, Sosuke Yoshinaga, Miki Ohira, Ming-Rong Zhang, Kazuhiro Okumura, Yuya Terashima, Hirotatsu Kojima, Kana Kokubo, Ming Chen Chen, Mikiya Otsuji, Yoshihiro Komohara, Yutaka Kofuku, Hirofumi Rokutan, Hiroaki Terasawa, Kouji Matsushima, Akira Shimizu
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Tumor-associated macrophages affect tumor progression and resistance to immune checkpoint therapy. Here, we identify the chemokine signal regulator FROUNT as a target to control tumor-associated macrophages. The low level FROUNT expression in patient
Autor:
Hitoshi Shimano, Jun Abe, Tatsuya Tsukui, Satoshi Ueha, Kouji Matsushima, Mizuha Kosugi-Kanaya, Francis H. W. Shand, Shigeyuki Shichino, Shin-ichi Hashimoto, Shungo Deshimaru, Yutaka Inagaki, Takuya Nakajima, Mikiya Otsuji
Publikováno v:
JCI Insight. 4
Pulmonary fibrosis (PF) is an intractable disorder with a poor prognosis. Although lung fibroblasts play a central role in PF, the key regulatory molecules involved in this process remain unknown. To address this issue, we performed a time-course tra
Autor:
Nobuko Ito, Kohshi Hattori, Mikiya Otsuji, Masaaki Asamoto, Yoko Hashimoto, Yoshitsugu Yamada, Satoshi Kasahara
Publikováno v:
Journal of clinical monitoring and computing. 34(2)
Clinical anesthesiologists, particularly residents, work in stressful environments. However, evidence-based physiological and psychological tests to evaluate stress are still lacking. In this single-center study of 33 residents, we investigated the r
Autor:
Takayoshi Okabe, Ichio Shimada, Koji Ohnishi, Francis H. W. Shand, Etsuko Toda, Hiroki Nagase, Toshihiko Iizasa, Hirofumi Nakano, Hiroaki Terasawa, Kouji Matsushima, Yoshihiro Komohara, Hirotatsu Kojima, Meiji Itakura, Yutaka Kofuku, Sana Yokoi, Kazuhiro Okumura, Ming-Rong Zhang, Hirofumi Rokutan, Mikiya Otsuji, Shiro Kanegasaki, Yuya Terashima, Miki Ohira, Sosuke Yoshinaga
Publikováno v:
SSRN Electronic Journal.
Tumor-associated macrophages influence tumor progression and resistance to immune checkpoint therapy. Chemokine signaling is a key regulator of macrophage accumulation and activity. Here, we report that the chemokine receptor-binding protein FROUNT m
Publikováno v:
Canadian journal of physiology and pharmacology. 95(2)
Varying temperature affects cardiac systolic and diastolic function and the left ventricular (LV) pressure–time curve (PTC) waveform that includes information about LV inotropism and lusitropism. Our proposed half-logistic (h-L) time constants obta
Publikováno v:
Acta Cardiologica Sinica. 29(4)
Myocardial contraction and relaxation are regulated by increases and decreases in intracellular cytoplasmic calcium (Ca(2+)) concentration ([Ca(2+)]i). In previous studies, we found that a half-logistic (h-L) function, which represents a half-curve o