Výsledky vyhledávání - "Mikio Kabaki"

Development of Safe, Scalable Nitric Acid Oxidation Using a Catalytic Amount of NaNO2 for 3-Bromo-2,2-bis(bromomethyl)propanoic Acid: An Intermediate of S-013420

Autor: Hiroshi Osato, Sumio Shimizu, Mikio Kabaki

Publikováno v: Organic Process Research & Development. 15:581-584

A safe, scalable process was developed for nitric acid oxidation of 3-bromo-2,2-bis(bromomethyl)propan-1-ol (2) to give 3-bromo-2,2-bis(bromomethyl)propanoic acid (3), an intermediate in the synthe...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f532e21a88d3e84c4adfc0b6c99a7b02
https://doi.org/10.1021/op1003133

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Practical Application of Oxidation Using a Novel Na2WO4−H2O2 System under Neutral Conditions for Scale-Up Manufacturing of 12α-Hydroxy-3-oxooleanano-28,13-lactone: Key Intermediate of Endothelin A Receptor Antagonist S-0139

Autor: Toshiaki Masui, Mikio Kabaki, Masataka Fumoto, Yuuki Fukui, Kyozo Kawata, Hideo Nogusa, Takemasa Hida

Publikováno v: Organic Process Research & Development. 14:289-294

Novel alcohol oxidation using a Na2WO4−H2O2 system was applied to manufacture 12α-hydroxy-3-oxooleanano-28,13-lactone which is a key intermediate of S-0139. Oxidation of the hydroxyl group of oleanolic acid was optimized based on the design of exp

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https://doi.org/10.1021/op900265h

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The Microtubule Stabilizing Agent Laulimalide Does Not Bind in the Taxoid Site, Kills Cells Resistant to Paclitaxel and Epothilones, and May Not Require Its Epoxide Moiety for Activity

Autor: Yuefang Wang, and Paraskevi Giannakakou, Arun K. Ghosh, J. Fernando Díaz, José Manuel Andreu, Mikio Kabaki, Donald E. Pryor, Yong Wang, Aurora O'Brate, Geoffrey Bilcer, M. Katherine Jung, Ernest Hamel

Publikováno v: Biochemistry. 41:9109-9115

Laulimalide is a cytotoxic natural product that stabilizes microtubules. The compound enhances tubulin assembly, and laulimalide is quantitatively comparable to paclitaxel in its effects on the reaction. Laulimalide is also active in P-glycoprotein o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d6c9fc7fe10be111c036d99aba90190
https://doi.org/10.1021/bi020211b

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One-Step Synthesis of 5-(4-Fluorobenzyl)-2-furyl Methyl Ketone: A Key Intermediate of HIV-Integrase Inhibitor S-1360

Autor: Masaaki Uenaka, Sumio Shimizu, Kenji Izumi, Mikio Kabaki

Publikováno v: Organic Process Research & Development. 11:1059-1061

Practical one-step synthesis of 5-(4-fluorobenzyl)-2-furyl methyl ketone was accomplished by Friedel–Crafts benzylation of 2-furyl methyl ketone with 4-fluorobenzyl chloride in the presence of ZnCl2. Two reaction conditions and their work-up proced

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https://doi.org/10.1021/op700117q

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Practical One-Pot Synthesis of N-(tert-Butoxycarbonyl)sulfamide from Chlorosulfonyl Isocyanate via N-(tert-Butoxycarbonyl)aminosulfonylpyridinium Salt

Autor: Yoshiyuki Masui, Mikio Kabaki, Hideaki Watanabe, Toshiaki Masui, Tatsuya Kobayashi

Publikováno v: Organic Process Research & Development. 8:408-410

An efficient and practical process for the one-pot synthesis of N-(tert-butoxycarbonyl)sulfamide (4), a raw material for the aminosulfamoyl-containing side chain 3 of a novel carbapenem antibiotic doripenem hydrate (S-4661: 1), is described. In the p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::77f86773971dc709a70f070ae1ab7e77
https://doi.org/10.1021/op0499728

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ChemInform Abstract: Reaction of Metal-Free Triorganogermyl Anions with Aldehydes

Autor: Yoko Nagata, Mikio Kabaki, Yoshiro Sato, S. Inoue

Publikováno v: ChemInform. 22

Hexaorganosilylgermane (2) reacted with aldehydes and ketones (1) in the presence of catalytic amounts of fluoride ion in THF or HMPA to give 1-(triorgano-germyl)alkyl alcohols (3).

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https://doi.org/10.1002/chin.199115225

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Reaction of Triorgano(Triorganogermyl)Silanes with Alkali-Metal Allyl Aicoholates

Autor: Mikio Kabaki, Sumie Inoue, Yoshiro Sato

Publikováno v: Synthetic Communications. 22:459-466

Reaction of the lithium alcoholales of 1-vinylcyclohexanol (2a), (±)-linalool (2b), and 1-octen-3-ol (2c) with (dimethylphenylgermyl)trimethylsilane (3a) gave selectively the corresponding allyldimethylphenylgermane derivatives (5a,c,e). Similar tre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2eb0cb4d00f4f1fc6547a9d2424bc11b
https://doi.org/10.1080/00397919208055424

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Reaction of Metal-Free Triorganogermyl Anions with Aldehydes

Autor: Mikio Kabaki, Yoshiro Sato, Yoko Nagata, S. Inoue

Publikováno v: Synthetic Communications. 20:3245-3252

Hexaorganosilylgermane (2) reacted with aldehydes and ketones (1) in the presence of catalytic amounts of fluoride ion in THF or HMPA to give 1-(triorgano-germyl)alkyl alcohols (3).

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::635dfdef599800113a8d9fc565f7c4cd
https://doi.org/10.1080/00397919008051552

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