Zobrazeno 1 - 10
of 134
pro vyhledávání: '"Mikio Arisawa"'
Autor:
Toshiyuki Sakai, Yuko Aoki, Neal Rosen, Poulikos I. Poulikakos, Yoshihiro Sowa, Mikio Arisawa, Nobuo Shimma, Toshihiro Aoki, Hitoshi Iikura, Yukako Tachibana-Kondo, Yasushi Tomii, Yutaka Matsuda, Hiroshi Sakamoto, Takaaki Miura, Kazuhiro Ohara, Eric W. Joseph, Naoki Harada, Nobuya Ishii
Supplementary Table S3 - PDF file 54K, Binding constant between CH5126766 and non-phosphorylated MEK1. Non-phosphorylated His6-MEK1 (WT) was imobilized and affinities between His6-MEK1 and MEK inhibitors were analyzed with SPR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b5f67b52f9034817d856805e70d2d99
https://doi.org/10.1158/0008-5472.22395615
https://doi.org/10.1158/0008-5472.22395615
Autor:
Toshiyuki Sakai, Yuko Aoki, Neal Rosen, Poulikos I. Poulikakos, Yoshihiro Sowa, Mikio Arisawa, Nobuo Shimma, Toshihiro Aoki, Hitoshi Iikura, Yukako Tachibana-Kondo, Yasushi Tomii, Yutaka Matsuda, Hiroshi Sakamoto, Takaaki Miura, Kazuhiro Ohara, Eric W. Joseph, Naoki Harada, Nobuya Ishii
Tumors with mutant RAS are often dependent on extracellular signal–regulated kinase (ERK) signaling for growth; however, MEK inhibitors have only marginal antitumor activity in these tumors. MEK inhibitors relieve ERK-dependent feedback inhibition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d6d6624da24b766920d5ee7c74276a2
https://doi.org/10.1158/0008-5472.c.6504354.v1
https://doi.org/10.1158/0008-5472.c.6504354.v1
Autor:
Toshiyuki Sakai, Yuko Aoki, Neal Rosen, Poulikos I. Poulikakos, Yoshihiro Sowa, Mikio Arisawa, Nobuo Shimma, Toshihiro Aoki, Hitoshi Iikura, Yukako Tachibana-Kondo, Yasushi Tomii, Yutaka Matsuda, Hiroshi Sakamoto, Takaaki Miura, Kazuhiro Ohara, Eric W. Joseph, Naoki Harada, Nobuya Ishii
Supplementary Figure S1 - PDF file 70K, Induction of p27Kip1 protein and cell cycle arrest by CH5126766
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b272c3326137d6cf173146780cfce50
https://doi.org/10.1158/0008-5472.22395636.v1
https://doi.org/10.1158/0008-5472.22395636.v1
Autor:
Toshiyuki Sakai, Yuko Aoki, Neal Rosen, Poulikos I. Poulikakos, Yoshihiro Sowa, Mikio Arisawa, Nobuo Shimma, Toshihiro Aoki, Hitoshi Iikura, Yukako Tachibana-Kondo, Yasushi Tomii, Yutaka Matsuda, Hiroshi Sakamoto, Takaaki Miura, Kazuhiro Ohara, Eric W. Joseph, Naoki Harada, Nobuya Ishii
Supplementary Materials and Methods - PDF file 65K, Antibodies and kinase panel assays
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01d3675432925f1de4e4eff25dee105c
https://doi.org/10.1158/0008-5472.22395624
https://doi.org/10.1158/0008-5472.22395624
Autor:
Yasushi Tomii, Hiroshi Sakamoto, Toshihiro Aoki, Kazuhiro Ohara, Poulikos I. Poulikakos, Yoshihiro Sowa, Nobuo Shimma, Yuko Aoki, Neal Rosen, Mikio Arisawa, Yukako Tachibana-Kondo, Nobuya Ishii, Eric W. Joseph, Hitoshi Iikura, Naoki Harada, Toshiyuki Sakai, Takaaki Miura, Yutaka Matsuda
Publikováno v:
Cancer Research. 73:4050-4060
Tumors with mutant RAS are often dependent on extracellular signal–regulated kinase (ERK) signaling for growth; however, MEK inhibitors have only marginal antitumor activity in these tumors. MEK inhibitors relieve ERK-dependent feedback inhibition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9319805b9b026830a7ef25bec51d707f
https://doi.org/10.1158/0008-5472.can-12-3937
https://doi.org/10.1158/0008-5472.can-12-3937
Autor:
Jun Ohwada, Mikio Arisawa, Malcolm G. P. Page, Yukiko Inagaki, Masao Tsukazaki, Kazuko Kobayashi, Toshikazu Yamazaki, Isao Umeda, Nobuo Shimma, Toshihiko Fujii
Publikováno v:
International Journal of Antimicrobial Agents. 36:324-331
The in vitro susceptibilities of 140 laboratory reference strains of fungi, including type strains, and 165 clinical yeast isolates from Japan towards isavuconazole compared with fluconazole (FLC), itraconazole (ITC), voriconazole and amphotericin B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::444a8d15e1ba0936050a337bc455c07e
https://doi.org/10.1016/j.ijantimicag.2010.06.003
https://doi.org/10.1016/j.ijantimicag.2010.06.003
Publikováno v:
FEMS Microbiology Letters. 149:279-284
A complementary DNA of the Aspergillus nidulans chsB gene encoding chitin synthase, an essential gene for hyphal growth, was obtained by RT-PCR and expressed in Saccharomyces cerevisiae by using the GAL1 promoter in a multicopy plasmid. The biochemic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::77f79c47f3b384ed8cb5a67b9d3df4aa
https://doi.org/10.1111/j.1574-6968.1997.tb10341.x
https://doi.org/10.1111/j.1574-6968.1997.tb10341.x
Autor:
Atsunori Ohta, Hideyuki Kato, Hiroshi Sakamoto, Yuko Aoki, Michinori Kohara, Koichi Okamoto, Masahiro Aoki, Mikio Arisawa, Asao Katsume, Takuo Tsukuda, Nobuo Shimma, Masayuki Sudoh
Publikováno v:
Nature Chemical Biology. 1:333-337
An estimated 170 million individuals worldwide are infected with hepatitis C virus (HCV), a serious cause of chronic liver disease. Current interferon-based therapy for treating HCV infection has an unsatisfactory cure rate, and the development of mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::539907b28c907d09f1fdec8d2fcfad11
https://doi.org/10.1038/nchembio742
https://doi.org/10.1038/nchembio742
Autor:
Takahide Watanabe, Nobuo Shimma, Yoshikazu Ohya, Hiroshi Fukuda, Osamu Kondoh, Mikio Arisawa, Eisaku Mizuguchi, Yuko Aoki, Yukiko Inagaki, Masahiro Sakaitani
Publikováno v:
Biological and Pharmaceutical Bulletin. 28:2138-2141
1,3-beta-D-Glucan synthase, which synthesizes a main component of fungal cell wall, is one of the promising targets for antifungal agents. In order to identify novel chemical classes of 1,3-beta-D-glucan synthase inhibitors, we screened a chemical li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db3ecae6d4ed2f0fbfc53a4ed57368ac
https://doi.org/10.1248/bpb.28.2138
https://doi.org/10.1248/bpb.28.2138
Autor:
Mikio Arisawa, Hironobu Nakayama
Publikováno v:
Nippon Ishinkin Gakkai Zasshi. 44:107-114
A system to regulate gene expression is a convenient tool to explore gene function(s) not only in prokaryote but also in eukaryote. Such manipulation tools are scarce in the medical mycology field due to its complexity and diploidity. Although system
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18c4d96dd3512c047df8e1d0dea36586
https://doi.org/10.3314/jjmm.44.107
https://doi.org/10.3314/jjmm.44.107