Zobrazeno 1 - 10 of 67 pro vyhledávání: '"Mikio, Tomita"'
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Intestinal Absorption of Alogliptin Is Mediated by a Fruit-Juice-Sensitive Transporter
Autor: Mikio Tomita, Makoto Ishii, Momona Sasaki, Takuo Ogihara, Kaori Morimoto, Erika Oikawa, Tatsuro Kikuchi, Maho Abe
Publikováno v: Biologicalpharmaceutical bulletin. 44(5)
Alogliptin (ALG), an inhibitor of dipeptidylpeptidase-4, is used in the management of type 2 diabetes mellitus, and has a high absorption rate (>60-71%), despite its low lipophilicity (logP=-1.4). Here, we aimed to clarify the mechanism of its intest
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0785346f11684c0a1aff1f70f594f1c7
https://pubmed.ncbi.nlm.nih.gov/33952821
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3
Increased membrane permeation and blood concentration of 6-carboxyfluorescein associated with dysfunction of paracellular route barrier in the small intestine of ulcerative colitis model rats
Autor: Kaori Morimoto, Maho Kumagai, Makoto Ishii, Mikio Tomita
Publikováno v: Biopharmaceuticsdrug dispositionREFERENCES. 41(3)
In the colon of patients with ulcerative colitis (UC), decreased function of the paracellular barrier, especially hypofunction of the tight junction, is associated with pathological conditions. However, there has been no report to date on the functio
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84a46006dcb262d533bde150a984097c
https://pubmed.ncbi.nlm.nih.gov/32043274
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4
Retraction Note to: Changes of Absorptive and Secretory Transporting System of (1 → 3) β-D-glucan Based on Efflux Transporter in Indomethacin-induced Rat
Autor: Toshio Oda, Jun Aketagawa, Yasuhiko Ito, Shohei Ouchi, Mikio Tomita, Yusuke Takizawa, Masahiro Hayashi, Aiko Iida
Publikováno v: European journal of drug metabolism and pharmacokinetics. 43(6)
The Editor-in-Chief has retracted this article [1] based on an investigation by the Ministry of Education, Culture, Sports, Science and Technology, Japan, which found that the article contained overlap with a previously published article by Kalitsky-
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edf694697abd241fccf857532410e904
https://pubmed.ncbi.nlm.nih.gov/24515798
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5
Intestinal secretion of indoxyl sulfate as a possible compensatory excretion pathway in chronic kidney disease
Autor: Masanari Miyamoto, Yuuta Tominaga, Yoshimi Sano, Kentaro Yano, Shota Kashiwagura, Yuta Agatsuma, Kaori Morimoto, Takuo Ogihara, Mikio Tomita, Akira Takahashi, Chihaya Kakinuma
Publikováno v: Biopharmaceuticsdrug disposition. 39(7)
Indoxyl sulfate (IS) is a protein-bound uremic toxin that progressively accumulates in plasma during chronic kidney disease (CKD), and its accumulation is associated with the progression of CKD. This study examined the intestinal secretion of IS usin
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba281392f0d98846623ee1868167de66
https://pubmed.ncbi.nlm.nih.gov/29975986
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6
RETRACTED ARTICLE: Changes of Absorptive and Secretory Transporting System of (1 → 3) β-D-glucan Based on Efflux Transporter in Indomethacin-induced Rat
Autor: Mikio Tomita, Yusuke Takizawa, Yasuhiko Ito, Aiko Iida, Toshio Oda, Jun Aketagawa, Masahiro Hayashi, Shohei Ouchi
Publikováno v: European Journal of Drug Metabolism and Pharmacokinetics. 40:29-38
Infection and inflammation suppress the expression and activity of several drug transporters in liver. In the intestine, P-glycoprotein (P-gp/MDR1), multidrug resistance-associated protein 2 (MRP2), and breast cancer resistance protein (BCRP) are imp
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ff13ee06d8c782d0929e497926616497
https://doi.org/10.1007/s13318-014-0174-0
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8
RETRACTED: Suppression of efflux transporters in the intestines of endotoxin-treated rats
Autor: Megumi Hatanaka, Mariko Nakaike, Mikio Tomita, Yusuke Takizawa, Atsushi Kanbayashi, Ayako Tanaka, Masahiro Hayashi, Tomomi Kai, Hiroyuki Murata
Publikováno v: International Journal of Pharmaceutics. 428:33-38
Infection and inflammation suppress the expression and activity of several drug transporters in the liver. In the intestine, P-glycoprotein (PGP/mdr1) and the multidrug resistance-associated protein 2 (MRP2) are important barriers to the absorption o
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4041bacd024d49391cc909ad98bfb107
https://doi.org/10.1016/j.ijpharm.2012.02.027
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9
Effects of nitric oxide on mucosal barrier dysfunction during early phase of intestinal ischemia/reperfusion
Autor: Takuya Kitazato, Masahiro Hayashi, Yusuke Takizawa, Hisanao Kishimoto, Mikio Tomita
Publikováno v: European Journal of Pharmaceutical Sciences. 42:246-252
Ischemia/reperfusion (I/R) injury must be overcome for successful small intestinal transplantation. During intestinal I/R, the expression level of nitric oxide (NO) is increased, and vermiculation of the mucosal tract is induced by NO. Although NO ha
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3445232310e1d14b6f1f0dde9de94a2
https://doi.org/10.1016/j.ejps.2010.11.016
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10
Effect of Aminoguanidine on Ischemia/Reperfusion Injury in Rat Small Intestine
Autor: Yusuke Takizawa, Naomi Kamiya, Mikio Tomita, Masahiro Hayashi, Takuya Kitazato, Haruka Ishizaka
Publikováno v: Biological and Pharmaceutical Bulletin. 34:1737-1743
Ischemia/reperfusion (I/R) injury is induced by reactive oxygen species (ROS). During intestinal I/R, the amount of nitric oxide (NO), which is a ROS, is increased. In this study, we examined the protection against I/R injury by inhibition of NO gene
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c4c39f36fa4a61e69166562f4d4887a
https://doi.org/10.1248/bpb.34.1737
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