Zobrazeno 1 - 10
of 79
pro vyhledávání: '"Mikinori, Torii"'
Autor:
Keigo Matsuyama, Yoshiji Asaoka, Kae Fujisawa, Miho Mukai, Mikinori Torii, Minako Tajiri, Ryo D Obara, Yuki Kato, Tamio Fukushima
Publikováno v:
Journal of Toxicologic Pathology
A 6-month-old female beagle dog, assigned to the low-dose group in a toxicity study, was evaluated for compound toxicity, and spontaneous hyperadrenocorticism was suspected. The animal had an externally apparent distended abdomen on clinical examinat
Autor:
Haruaki Nobori, Keita Fukao, Takayuki Kuroda, Naomi Anan, Ryoichi Tashima, Masaaki Nakashima, Sayuri Noda, Minako Tajiri, Mikinori Torii, Shinsuke Toba, Kentaro Uemura, Takao Sanaki, Takao Shishido, Yuki Tachibana, Teruhisa Kato
Publikováno v:
The Journal of antimicrobial chemotherapy. 77(11)
Objectives Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the aetiological agent of coronavirus disease 2019 (COVID-19) and a devastating worldwide health concern. Development of safe and effective treatments is not only important fo
Autor:
Kazuhisa Minami, Minoru Hasegawa, Hisanori Ito, Atsushi Nakamura, Takako Tomii, Mitsunobu Matsumoto, Satoshi Orita, Syuichi Matsushima, Takako Miyoshi, Koichi Masuno, Mikinori Torii, Katsumi Koike, Shinji Shimada, Toshiyuki Kanemasa, Tsuyoshi Kihara, Minoru Narita, Tsutomu Suzuki, Akira Kato
Publikováno v:
Journal of Pharmacological Sciences, Vol 111, Iss 1, Pp 60-72 (2009)
Morphine, oxycodone, and fentanyl are clinically prescribed drugs for the management of severe pain. We investigated whether these opioids possess different efficacy profiles on several types of pain in mouse pain models. When the three opioids were
Externí odkaz:
https://doaj.org/article/008c1894dc1248a68fb930e82144eebf
Publikováno v:
Journal of Toxicologic Pathology
The present report describes an adrenal dysplasia in which developmental abnormality was observed in the adrenal gland of a six-week-old male Crl:CD(SD) rat. Microscopically, a localized lesion composed of mildly vacuolated adrenal fasciculata cells
Autor:
Jyoji Yamate, Mitsuru Kuwamura, Takeshi Izawa, Noriko Tsuchiya, Kae Fujisawa, Mikinori Torii, Koichi Masuno, Yuki Kato, Atsuko Hishikawa
Publikováno v:
Experimental and Toxicologic Pathology. 69:413-423
We herein investigated the histopathological features, including proliferative activity and immunoexpression, of pancreatic islet cell tumors (ICTs) in male SD rats induced by streptozotocin (STZ) and nicotinamide (NA), and discussed their relevance
Autor:
Atsuko Hishikawa, Yusaku Masago, Erika Yogo, Jyoji Yamate, Takeshi Izawa, Mitsuru Kuwamura, Chiaki Kondo, Mikinori Torii, Yuki Kato
Publikováno v:
Toxicologic pathology. 46(6)
To identify the molecular profiles of islets from alloxan (ALX)- and streptozotocin (STZ)-treated rats, a microarray-based global gene expression analysis was performed on frozen islets isolated via laser capture microdissection. At 6 weeks old, rats
Autor:
Ken-ichi Nezasa, Mikinori Torii, Satomi Shinonome, Hidekazu Tanaka, Michinari Hirata, Yukari Tanaka
Publikováno v:
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
Epertinib (S-222611) is a potent, reversible, and selective tyrosine kinase inhibitor of epidermal growth factor receptor (EGFR), human EGFR2 (HER2), and human EGFR4. We developed experimental brain metastasis models by intraventricular injection (in
Autor:
Yuji Morikawa, Mikinori Torii, Takeki Uehara, Keigo Matsuyama, Yuki Kato, Hiroyuki Hanafusa, Yutaka Tonomura, Motonobu Ueno
Publikováno v:
Journal of Applied Toxicology. 35:165-172
Traditional biomarkers such as alanine and aspartate aminotransferase (ALT, AST) and total bilirubin (TBIL) have been widely used for detecting drug-induced liver injury (DILI). Although the Food and Drug Administration (FDA) proposed standardized th
Autor:
Yoko Nishimura, Yutaka Tonomura, Takeki Uehara, Mikinori Torii, Jyoji Yamate, Chiaki Kondo, Yuji Morikawa
Publikováno v:
Journal of Applied Toxicology. 35:173-180
Cardiotoxicity is one of the major safety concerns in drug development. Therefore, detecting and monitoring cardiotoxicity throughout preclinical and clinical studies is important for pharmaceutical companies. The present study was conducted in order
Autor:
Takeki Uehara, Yoko Nishimura, Chiaki Kondo, Mikinori Torii, Yuji Morikawa, Yutaka Tonomura, Ryou Fukushima
Publikováno v:
Journal of Applied Toxicology. 33:1120-1130
The development of safer drugs is a high priority for pharmaceutical companies. Among the various toxicities caused by drugs, cardiotoxicity is an important issue because of its lethality. In addition, cardiovascular toxicity leads to the attrition o