Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Mikin M. Patel"'
Autor:
Wenbin Liang, Robert G. Tsushima, Ajay M. Shah, Gavin Y. Oudit, Peter H. Backx, James R. Woodgett, Michael E. Ward, Mikin M. Patel
Publikováno v:
Hypertension. 56:422-429
Although angiotensin II (Ang II) plays an important role in heart disease associated with pump dysfunction, its direct effects on cardiac pump function remain controversial. We found that after Ang II infusion, the developed pressure and +dP/dt max i
Autor:
Gavin Y. Oudit, Josef M. Penninger, Adil Bhatti, Mikin M. Patel, Sara Samuel, Peter H. Backx, Seigo Izumo, Robert G. Tsushima, Andrew J. Cooper, Kiwon Ban
Publikováno v:
Circulation Research. 103:643-653
Ischemic preconditioning (IPC) is a potent cellular protective mechanism whereby brief periods of sublethal ischemia protect the myocardium from prolonged ischemia-induced injury. We demonstrate the selective role of phosphatidylinositol 3-kinase (PI
Autor:
Evangelia G. Kranias, Peter H. Backx, Wenping Li, Mikin M. Patel, Thomas Kislinger, David H. MacLennan, Anthony O. Gramolini, Maria G. Trivieri, Gavin Y. Oudit, Andrew Emili
Publikováno v:
Proceedings of the National Academy of Sciences. 103:2446-2451
Sarcolipin (SLN) inhibits the cardiac sarco(endo)plasmic reticulum Ca 2+ ATPase (SERCA2a) by direct binding and is superinhibitory if it binds as a binary complex with phospholamban (PLN). To demonstrate whether overexpression of SLN in the heart mig
Autor:
Pierre Rustin, Nicholas Joza, Karin Nowikovsky, Anne Vassault, Paule Bénit, Gavin Y. Oudit, Zamaneh Kassiri, Josef M. Penninger, Teiji Wada, Doris Brown, Peter H. Backx, Loralyn Benoit, Mikin M. Patel, Nicola Vahsen, Guido Kroemer
Publikováno v:
Molecular and Cellular Biology. 25:10261-10272
Cardiac and skeletal muscle critically depend on mitochondrial energy metabolism for their normal function. Recently, we showed that apoptosis-inducing factor (AIF), a mitochondrial protein implicated in programmed cell death, plays a role in mitocho
Autor:
Patrick E. MacDonald, Zeenat Asghar, Jingyu Diao, Feihan F. Dai, Jamie W. Joseph, Gavin Y. Oudit, Mikin M. Patel, Peter H. Backx, Daphne Yau, Michael B. Wheeler
Publikováno v:
Endocrinology. 145(9)
Phosphoinositide 3-kinase (PI3 kinase) has been implicated in G protein-coupled receptor regulation of pancreatic beta-cell growth and glucose-stimulated insulin secretion. The G protein-activated p110gamma isoform of PI3 kinase was detected in insul