Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Mikiko Oka"'
Publikováno v:
iScience, Vol 24, Iss 1, Pp 101979- (2021)
Summary: Brain neurons play a central role in organismal aging, but there is conflicting evidence about the role of neuronal glucose availability because glucose uptake and metabolism are associated with both aging and extended life span. Here, we an
Externí odkaz:
https://doaj.org/article/faba0d1946654776934cbe6aa2797a2a
Autor:
Taro Saito, Saori Abe, Mika Nobuhara, Akiko Asada, Toshiya Oba, Tomoki Chiku, Satoko Wada-Kakuda, Akihiko Takashima, Mikiko Oka, Kanae Ando, Tomohiro Miyasaka, Kanako Shinno, Akio Sumioka
Publikováno v:
Human Molecular Genetics
Accumulation of microtubule-associated tau protein is thought to cause neuron loss in a group of neurodegenerative diseases called tauopathies. In diseased brains, tau molecules adopt pathological structures that propagate into insoluble forms with d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24096c5eef3b0b4eced5205a65a631b9
https://doi.org/10.1093/hmg/ddab162
https://doi.org/10.1093/hmg/ddab162
SummaryBrain neurons play a central role in organismal aging, but there is conflicting evidence about the roles of neuronal glucose availability, glucose uptake and metabolism in aging and extended lifespan. Here, we analyzed metabolic changes in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1410b379a77317c1028b28ad999f7012
https://doi.org/10.1101/2020.06.11.145227
https://doi.org/10.1101/2020.06.11.145227
Autor:
Mikiko Oka1, Naoki Fujisaki2,3, Akiko Maruko-Otake4, Yosuke Ohtake4,5, Sawako Shimizu1, Taro Saito1, Shin-Ichi Hisanaga1, Iijima, Koichi M.2,3,6 iijimakm@ncgg.go.jp, Kanae Ando1 k_ando@tmu.ac.jp
Publikováno v:
Journal of Biochemistry. Nov2017, Vol. 162 Issue 5, p335-342. 8p.
Autor:
Yosuke Ohtake, Taro Saito, Sawako Shimizu, Kanae Ando, Naoki Fujisaki, Shin-ichi Hisanaga, Koichi M. Iijima, Mikiko Oka, Akiko Maruko-Otake
Publikováno v:
The Journal of Biochemistry. 162:335-342
Abnormal deposition of the microtubule-associated protein tau is a common pathological feature of multiple neurodegenerative diseases, including Alzheimer's disease (AD), and plays critical roles in their pathogenesis. Disruption of calcium homeostas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b7a02d2dd5875123b203c89e1b931b3
https://doi.org/10.1093/jb/mvx038
https://doi.org/10.1093/jb/mvx038
Publikováno v:
iScience, Vol 24, Iss 1, Pp 101979-(2021)
iScience
iScience
Summary Brain neurons play a central role in organismal aging, but there is conflicting evidence about the role of neuronal glucose availability because glucose uptake and metabolism are associated with both aging and extended life span. Here, we ana
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea8fae363a8ad020c4d54efdbe1d5167
https://doi.org/10.1016/j.isci.2020.101979
https://doi.org/10.1016/j.isci.2020.101979
Autor:
Taro Saito, Motoki Hayashishita, Sawako Shimizu, Tomoki Chiku, Yosuke Ohtake, Akiko Asada, Kanae Ando, Koichi M. Iijima, Kanako Shinno, Mikiko Oka, Shin-ichi Hisanaga
Publikováno v:
Neurobiology of aging. 71
Abnormal accumulation of the microtubule-associated protein tau is thought to cause neuronal cell death in a group of age-associated neurodegenerative disorders. Tau is phosphorylated at multiple sites in diseased brains, and phosphorylation of tau a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af5217430ccef560e2e98822a0e2b86f
https://pubmed.ncbi.nlm.nih.gov/30172839
https://pubmed.ncbi.nlm.nih.gov/30172839
Autor:
Koichi M. Iijima, Sawako Shimizu, Mikiko Oka, Kanae Ando, Yosuke Ohtake, Shin-ichi Hisanaga, Motoki Hayashishita
Publikováno v:
Biochemical and biophysical research communications. 478(2)
Abnormal phosphorylation of the microtubule-associated protein tau is observed in many neurodegenerative diseases, including Alzheimer's disease (AD). AD-related phosphorylation of two tau residues, Ser262 and Ser356, by PAR-1/MARK stabilizes tau in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60a2d17e8f0c4f34848f394fb3670424
https://pubmed.ncbi.nlm.nih.gov/27520376
https://pubmed.ncbi.nlm.nih.gov/27520376
Autor:
Mitsuru Ito, Sawako Takahashi, Mikiko Okazaki-Hada, Mizuho Minakata, Kazuyoshi Kohsaka, Tomohiko Nakamura, Toshihiko Kasahara, Takumi Kudo, Eijun Nishihara, Shuji Fukata, Mitsushige Nishikawa, Takashi Akamiuzu, Akira Miyauchi
Publikováno v:
Thyroid Research, Vol 15, Iss 1, Pp 1-6 (2022)
Abstract Background In patients receiving thyroid-stimulating hormone (TSH) suppressive therapy with levothyroxine (LT4) after total thyroidectomy for thyroid cancer, thyroid function tests should be performed to adjust the LT4 dose. Specifically, se
Externí odkaz:
https://doaj.org/article/83ebe89256384b9d97f71c6296d0dfc2
Autor:
Mikiko Okazaki-Hada, Izumi Fukuda, Ryuta Nagaoka, Mototsugu Nagao, Takehito Igarashi, Shunsuke Kobayashi, Takeshi Oba, Yuji Yamaguchi, Tomoko Nagamine, Iwao Sugitani, Hitoshi Sugihara
Publikováno v:
Therapeutic Advances in Endocrinology and Metabolism, Vol 13 (2022)
Pheochromocytomas can present with various symptoms. Nonspecific manifestations of pheochromocytoma include intestinal pseudo-obstruction and weight loss. Here, we present a case of pheochromocytoma in which prolonged intestinal pseudo-obstruction du
Externí odkaz:
https://doaj.org/article/5ee0bff5e9ae43018acc83bd7c20309b