Zobrazeno 1 - 10
of 153
pro vyhledávání: '"Mikiko C, Siomi"'
Autor:
Hiroya Yamazaki, Yurika Namba, Shogo Kuriyama, Kazumichi M. Nishida, Asako Kajiya, Mikiko C. Siomi
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Bombyx Vasa assembles Vasa bodies, the site of transposon silencing by Siwi and Ago3-piRISC formation. Here, the authors show Vasa sequesters transposon mRNAs in Vasa bodies via phase separation requiring RNA binding and self-association of Vasa.
Externí odkaz:
https://doaj.org/article/0042f9a59af34a1387db541dad9dcefc
Autor:
Hiromi Yamada, Kazumichi M. Nishida, Yuka W. Iwasaki, Yosuke Isota, Lumi Negishi, Mikiko C. Siomi
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Siwi-piRISC protects the germline genome from DNA damage caused by selfish movement of transposons by suppressing their expression. Here, the authors show how molecularly Papi, which plays an important role in the production of Siwi-piRISC, cooperate
Externí odkaz:
https://doaj.org/article/25e88a75d92b4be1a12a3a1045ee983f
Autor:
Yurika Namba, Yuka W. Iwasaki, Kazumichi M. Nishida, Hidenori Nishihara, Tetsutaro Sumiyoshi, Mikiko C. Siomi
Publikováno v:
iScience, Vol 25, Iss 3, Pp 103914- (2022)
Summary: PIWI-interacting RNAs (piRNAs) bind to PIWI proteins to assemble the piRISC, which represses germline transposons. Maelstrom (Mael) is necessary for piRISC biogenesis in germ cells, but its function remains unclear. Here, we show that Mael i
Externí odkaz:
https://doaj.org/article/db07349de2f149349d5428e9be6ab5fe
Autor:
Bruno Mugat, Simon Nicot, Carolina Varela-Chavez, Christophe Jourdan, Kaoru Sato, Eugenia Basyuk, François Juge, Mikiko C. Siomi, Alain Pélisson, Séverine Chambeyron
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
In S. pombe, small non-coding RNA mediates heterochromatin formation by recruiting the nucleosome remodeling and histone deacetylase complex. Here, the authors show that fly nucleosome remodeler Mi-2 and histone deacetylase Rpd3 are involved in piRNA
Externí odkaz:
https://doaj.org/article/0dee362d68ea48919fcea68a5a855269
Autor:
Sonomi Yamaguchi, Akira Oe, Kazumichi M. Nishida, Keitaro Yamashita, Asako Kajiya, Seiichi Hirano, Naoki Matsumoto, Naoshi Dohmae, Ryuichiro Ishitani, Kuniaki Saito, Haruhiko Siomi, Hiroshi Nishimasu, Mikiko C. Siomi, Osamu Nureki
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
PIWI-clade Argonautes bind PIWI-interacting RNAs (piRNAs) to silence transposons and maintain genome integrity in animal gonads. Here the authors present the crystal structure of a Drosophila Piwi–piRNA complex isolated from cultured fly ovarian so
Externí odkaz:
https://doaj.org/article/9479ad5dbf9b4bffacfb69fcd7468085
Autor:
Yuta Uneme, Ryu Maeda, Gen Nakayama, Haruka Narita, Naoki Takeda, Ryuji Hiramatsu, Hidenori Nishihara, Ryuichiro Nakato, Yoshiakira Kanai, Kimi Araki, Mikiko C. Siomi, Soichiro Yamanaka
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America; 3/26/2024, Vol. 121 Issue 13, p1-11, 16p
Publikováno v:
Cell Reports, Vol 27, Iss 6, Pp 1822-1835.e8 (2019)
Summary: PIWI-interacting RNAs (piRNAs) repress transposons to maintain germline genome integrity. Previous studies showed that artificial tethering of Armitage (Armi) to reporter RNAs induced piRNA biogenesis. However, the lack of female sterile (1)
Externí odkaz:
https://doaj.org/article/74fc1218de4243a4ace108a5c7c40896
Autor:
Alfred W. Bronkhorst, Chop Y. Lee, Martin M. Möckel, Sabine Ruegenberg, Antonio M. de Jesus Domingues, Shéraz Sadouki, Tetsutaro Sumiyoshi, Mikiko C. Siomi, Lukas Stelzl, Katja Luck, René F. Ketting
Piwi-interacting RNAs (piRNAs) direct PIWI proteins to transposons to silence them, thereby preserving genome integrity and fertility. The piRNA population can be expanded in the ping-pong amplification loop. Within this process, piRNA-associated PIW
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f6656ad423457150531f34fbc351578f
https://doi.org/10.1101/2023.03.23.533951
https://doi.org/10.1101/2023.03.23.533951
Autor:
Shigeki Hirakata, Mikiko C. Siomi
Publikováno v:
Non-Coding RNA, Vol 5, Iss 4, p 52 (2019)
PIWI-interacting RNAs (piRNAs) are small non-coding RNAs that repress transposons in animal germlines. This protects the genome from the invasive DNA elements. piRNA pathway failures lead to DNA damage, gonadal development defects, and infertility. T
Externí odkaz:
https://doaj.org/article/7834dc4283744c35b1dced2d3b739edd
Autor:
Hirotsugu Ishizu, Yuka W. Iwasaki, Shigeki Hirakata, Haruka Ozaki, Wataru Iwasaki, Haruhiko Siomi, Mikiko C. Siomi
Publikováno v:
Cell Reports, Vol 12, Iss 3, Pp 429-440 (2015)
Primary piRNAs in Drosophila ovarian somatic cells arise from piRNA cluster transcripts and the 3′ UTRs of a subset of mRNAs, including Traffic jam (Tj) mRNA. However, it is unclear how these RNAs are determined as primary piRNA sources. Here, we i
Externí odkaz:
https://doaj.org/article/6fe840c429434b18ba1ef4c962f0d129