Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Mikihito Hayashi"'
Autor:
Anhao Liu, Mikihito Hayashi, Yujin Ohsugi, Sayaka Katagiri, Shizuo Akira, Takanori Iwata, Tomoki Nakashima
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Periodontitis, which is induced by repeated bacterial invasion and the ensuing immune reactions that follow, is the leading cause of tooth loss. Periodontal tissue is comprised of four different components, each with potential role in pathog
Externí odkaz:
https://doaj.org/article/43a7275d4aa6469d9a44a23dc2b97d49
Publikováno v:
Inflammation and Regeneration, Vol 40, Iss 1, Pp 1-16 (2020)
Abstract Receptor activator of NF-κB (RANK) ligand (RANKL) induces the differentiation of monocyte/macrophage–lineage cells into the bone–resorbing cells called osteoclasts. Because abnormalities in RANKL, its signaling receptor RANK, or decoy r
Externí odkaz:
https://doaj.org/article/4be31d9ac3f5417295c429639533be8e
Autor:
Ayumi Shoji-Matsunaga, Takehito Ono, Mikihito Hayashi, Hiroshi Takayanagi, Keiji Moriyama, Tomoki Nakashima
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
Abstract Orthodontic tooth movement is achieved by the remodeling of the alveolar bone surrounding roots of teeth. Upon the application of orthodontic force, osteoclastic bone resorption occurs on the compression side of alveolar bone, towards which
Externí odkaz:
https://doaj.org/article/4a9c73f4cfed481480672fecbdd1aa70
Autor:
Anhao Liu, Mikihito Hayashi, Yujin Ohsugi, Sayaka Katagiri, Shizuo Akira, Takanori Iwata, Tomoki Nakashima
Periodontitis, which is induced by repeated bacterial invasion and the ensuing immune reactions that follow, is the leading cause of tooth loss. However, studies on immune responses are usually based on gingival tissue, although periodontal tissue is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::00cbe5ea6eef6708871cf5ae143408fd
https://doi.org/10.21203/rs.3.rs-2696765/v1
https://doi.org/10.21203/rs.3.rs-2696765/v1
Publikováno v:
Endocrinology. 163(10)
Semaphorin 3A (Sema3A) coordinates bone resorption and formation under the control of estrogen signaling. However, the contribution of osteoblast lineage cell–derived Sema3A to vertebral homeostasis has remained unclear. Moreover, it is unknown whe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bb1cbdbd761ab0a8c180c5e795e1f47
https://pubmed.ncbi.nlm.nih.gov/35931046
https://pubmed.ncbi.nlm.nih.gov/35931046
Autor:
Masanobu Nagano, Hiroaki Suga, Junichi Takagi, Yukiko Matsunaga, Yan Wu, Nasir K Bashiruddin, Mikihito Hayashi, Tomoki Nakashima
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Osteoporosis affects over 75 million people globally, and this number is increasing with global median age. Therefore, the development of therapeutics with novel mechanisms of action is of high importance. Inhibition of the PlexinB1-Sema
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f220681f9bddb3bf933dd8d79fd2bcb5
https://doi.org/10.1073/pnas.2012266117
https://doi.org/10.1073/pnas.2012266117
Publikováno v:
Journal of bone and mineral metabolism. 39(1)
Receptor activator of nuclear factor-κB ligand (RANKL) is a key mediator of osteoclast differentiation and bone resorption. Osteoblast-lineage cells including osteoblasts and osteocytes express RANKL, which is regulated by several different factors,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebfc46bf92642193ce26998727c3f423
https://pubmed.ncbi.nlm.nih.gov/32889574
https://pubmed.ncbi.nlm.nih.gov/32889574
Autor:
Takanori Iwata, Masaki Kamakura, Yosuke Tsuchiya, Mikihito Hayashi, Katashi Nagamatsu, Tomoki Nakashima, Takehito Ono
Publikováno v:
J Biol Chem
The supplementation of royal jelly (RJ) is known to provide a variety of health benefits, including anti-inflammatory and anti-obesity effects. RJ treatment also reportedly protects against bone loss, but no single factor in RJ has yet been identifie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c013a3d9c8fd795199f3b01def69174
https://europepmc.org/articles/PMC7443481/
https://europepmc.org/articles/PMC7443481/
Publikováno v:
Science Advances. 6
Bone structure and function are maintained by well-regulated bone metabolism and remodeling. Although the underlying molecular and cellular mechanisms are now being understood, physiological and pathological states of bone are still difficult to pred
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56839fa95002f5b3419bd9b7d3d3a1bc
https://doi.org/10.1126/sciadv.aax0938
https://doi.org/10.1126/sciadv.aax0938
Bone is calcified hard tissue composed of type I collagen. It is regularly renewed by the balanced actions of osteoclastic bone resorption and osteoblastic bone formation, both of which mainly occur on the bone surface. The molecular understanding of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::50bce92f7e5b4fe43d9b4e54641f79da
https://doi.org/10.1016/b978-0-12-801238-3.11182-1
https://doi.org/10.1016/b978-0-12-801238-3.11182-1